The driver landscape of sporadic chordoma

The driver landscape of sporadic chordoma

Chordoma is a rare often incurable malignant bone tumour. Here, the authors investigate driver mutations of sporadic chordoma in 104 cases, revealing duplications in notochordal transcription factor brachyury (T), PI3K signalling mutations, and mutations in LYST, a potential novel cancer gene in cho...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Patrick S. Tarpey, Sam Behjati, Matthew D. Young, Inigo Martincorena, Ludmil B. Alexandrov, Sarah J. Farndon, Charlotte Guzzo, Claire Hardy, Calli Latimer, Adam P. Butler, Jon W. Teague, Adam Shlien, P. Andrew Futreal, Sohrab Shah, Ali Bashashati, Farzad Jamshidi, Torsten O. Nielsen, David Huntsman, Daniel Baumhoer, Sebastian Brandner, Jay Wunder, Brendan Dickson, Patricia Cogswell, Josh Sommer, Joanna J. Phillips, M. Fernanda Amary, Roberto Tirabosco, Nischalan Pillay, Stephen Yip, Michael R. Stratton, Adrienne M. Flanagan, Peter J. Campbell
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/208559b87d8a4491810952fc9347c3ba
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:208559b87d8a4491810952fc9347c3ba
record_format dspace
spelling oai:doaj.org-article:208559b87d8a4491810952fc9347c3ba2021-12-02T14:42:20ZThe driver landscape of sporadic chordoma10.1038/s41467-017-01026-02041-1723https://doaj.org/article/208559b87d8a4491810952fc9347c3ba2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01026-0https://doaj.org/toc/2041-1723Chordoma is a rare often incurable malignant bone tumour. Here, the authors investigate driver mutations of sporadic chordoma in 104 cases, revealing duplications in notochordal transcription factor brachyury (T), PI3K signalling mutations, and mutations in LYST, a potential novel cancer gene in chordoma.Patrick S. TarpeySam BehjatiMatthew D. YoungInigo MartincorenaLudmil B. AlexandrovSarah J. FarndonCharlotte GuzzoClaire HardyCalli LatimerAdam P. ButlerJon W. TeagueAdam ShlienP. Andrew FutrealSohrab ShahAli BashashatiFarzad JamshidiTorsten O. NielsenDavid HuntsmanDaniel BaumhoerSebastian BrandnerJay WunderBrendan DicksonPatricia CogswellJosh SommerJoanna J. PhillipsM. Fernanda AmaryRoberto TiraboscoNischalan PillayStephen YipMichael R. StrattonAdrienne M. FlanaganPeter J. CampbellNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-6 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Patrick S. Tarpey
Sam Behjati
Matthew D. Young
Inigo Martincorena
Ludmil B. Alexandrov
Sarah J. Farndon
Charlotte Guzzo
Claire Hardy
Calli Latimer
Adam P. Butler
Jon W. Teague
Adam Shlien
P. Andrew Futreal
Sohrab Shah
Ali Bashashati
Farzad Jamshidi
Torsten O. Nielsen
David Huntsman
Daniel Baumhoer
Sebastian Brandner
Jay Wunder
Brendan Dickson
Patricia Cogswell
Josh Sommer
Joanna J. Phillips
M. Fernanda Amary
Roberto Tirabosco
Nischalan Pillay
Stephen Yip
Michael R. Stratton
Adrienne M. Flanagan
Peter J. Campbell
The driver landscape of sporadic chordoma
description Chordoma is a rare often incurable malignant bone tumour. Here, the authors investigate driver mutations of sporadic chordoma in 104 cases, revealing duplications in notochordal transcription factor brachyury (T), PI3K signalling mutations, and mutations in LYST, a potential novel cancer gene in chordoma.
format article
author Patrick S. Tarpey
Sam Behjati
Matthew D. Young
Inigo Martincorena
Ludmil B. Alexandrov
Sarah J. Farndon
Charlotte Guzzo
Claire Hardy
Calli Latimer
Adam P. Butler
Jon W. Teague
Adam Shlien
P. Andrew Futreal
Sohrab Shah
Ali Bashashati
Farzad Jamshidi
Torsten O. Nielsen
David Huntsman
Daniel Baumhoer
Sebastian Brandner
Jay Wunder
Brendan Dickson
Patricia Cogswell
Josh Sommer
Joanna J. Phillips
M. Fernanda Amary
Roberto Tirabosco
Nischalan Pillay
Stephen Yip
Michael R. Stratton
Adrienne M. Flanagan
Peter J. Campbell
author_facet Patrick S. Tarpey
Sam Behjati
Matthew D. Young
Inigo Martincorena
Ludmil B. Alexandrov
Sarah J. Farndon
Charlotte Guzzo
Claire Hardy
Calli Latimer
Adam P. Butler
Jon W. Teague
Adam Shlien
P. Andrew Futreal
Sohrab Shah
Ali Bashashati
Farzad Jamshidi
Torsten O. Nielsen
David Huntsman
Daniel Baumhoer
Sebastian Brandner
Jay Wunder
Brendan Dickson
Patricia Cogswell
Josh Sommer
Joanna J. Phillips
M. Fernanda Amary
Roberto Tirabosco
Nischalan Pillay
Stephen Yip
Michael R. Stratton
Adrienne M. Flanagan
Peter J. Campbell
author_sort Patrick S. Tarpey
title The driver landscape of sporadic chordoma
title_short The driver landscape of sporadic chordoma
title_full The driver landscape of sporadic chordoma
title_fullStr The driver landscape of sporadic chordoma
title_full_unstemmed The driver landscape of sporadic chordoma
title_sort driver landscape of sporadic chordoma
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/208559b87d8a4491810952fc9347c3ba
work_keys_str_mv AT patrickstarpey thedriverlandscapeofsporadicchordoma
AT sambehjati thedriverlandscapeofsporadicchordoma
AT matthewdyoung thedriverlandscapeofsporadicchordoma
AT inigomartincorena thedriverlandscapeofsporadicchordoma
AT ludmilbalexandrov thedriverlandscapeofsporadicchordoma
AT sarahjfarndon thedriverlandscapeofsporadicchordoma
AT charlotteguzzo thedriverlandscapeofsporadicchordoma
AT clairehardy thedriverlandscapeofsporadicchordoma
AT callilatimer thedriverlandscapeofsporadicchordoma
AT adampbutler thedriverlandscapeofsporadicchordoma
AT jonwteague thedriverlandscapeofsporadicchordoma
AT adamshlien thedriverlandscapeofsporadicchordoma
AT pandrewfutreal thedriverlandscapeofsporadicchordoma
AT sohrabshah thedriverlandscapeofsporadicchordoma
AT alibashashati thedriverlandscapeofsporadicchordoma
AT farzadjamshidi thedriverlandscapeofsporadicchordoma
AT torstenonielsen thedriverlandscapeofsporadicchordoma
AT davidhuntsman thedriverlandscapeofsporadicchordoma
AT danielbaumhoer thedriverlandscapeofsporadicchordoma
AT sebastianbrandner thedriverlandscapeofsporadicchordoma
AT jaywunder thedriverlandscapeofsporadicchordoma
AT brendandickson thedriverlandscapeofsporadicchordoma
AT patriciacogswell thedriverlandscapeofsporadicchordoma
AT joshsommer thedriverlandscapeofsporadicchordoma
AT joannajphillips thedriverlandscapeofsporadicchordoma
AT mfernandaamary thedriverlandscapeofsporadicchordoma
AT robertotirabosco thedriverlandscapeofsporadicchordoma
AT nischalanpillay thedriverlandscapeofsporadicchordoma
AT stephenyip thedriverlandscapeofsporadicchordoma
AT michaelrstratton thedriverlandscapeofsporadicchordoma
AT adriennemflanagan thedriverlandscapeofsporadicchordoma
AT peterjcampbell thedriverlandscapeofsporadicchordoma
AT patrickstarpey driverlandscapeofsporadicchordoma
AT sambehjati driverlandscapeofsporadicchordoma
AT matthewdyoung driverlandscapeofsporadicchordoma
AT inigomartincorena driverlandscapeofsporadicchordoma
AT ludmilbalexandrov driverlandscapeofsporadicchordoma
AT sarahjfarndon driverlandscapeofsporadicchordoma
AT charlotteguzzo driverlandscapeofsporadicchordoma
AT clairehardy driverlandscapeofsporadicchordoma
AT callilatimer driverlandscapeofsporadicchordoma
AT adampbutler driverlandscapeofsporadicchordoma
AT jonwteague driverlandscapeofsporadicchordoma
AT adamshlien driverlandscapeofsporadicchordoma
AT pandrewfutreal driverlandscapeofsporadicchordoma
AT sohrabshah driverlandscapeofsporadicchordoma
AT alibashashati driverlandscapeofsporadicchordoma
AT farzadjamshidi driverlandscapeofsporadicchordoma
AT torstenonielsen driverlandscapeofsporadicchordoma
AT davidhuntsman driverlandscapeofsporadicchordoma
AT danielbaumhoer driverlandscapeofsporadicchordoma
AT sebastianbrandner driverlandscapeofsporadicchordoma
AT jaywunder driverlandscapeofsporadicchordoma
AT brendandickson driverlandscapeofsporadicchordoma
AT patriciacogswell driverlandscapeofsporadicchordoma
AT joshsommer driverlandscapeofsporadicchordoma
AT joannajphillips driverlandscapeofsporadicchordoma
AT mfernandaamary driverlandscapeofsporadicchordoma
AT robertotirabosco driverlandscapeofsporadicchordoma
AT nischalanpillay driverlandscapeofsporadicchordoma
AT stephenyip driverlandscapeofsporadicchordoma
AT michaelrstratton driverlandscapeofsporadicchordoma
AT adriennemflanagan driverlandscapeofsporadicchordoma
AT peterjcampbell driverlandscapeofsporadicchordoma
_version_ 1718389677315063808

Ejemplares similares