Hyperuricemia and overexcretion of uric acid increase the risk of simple renal cysts in type 2 diabetes

Abstract Previous studies have discussed the relationship between simple renal cysts (SRC) and serum uric acid level in healthy individuals. We performed a cross-sectional study to evaluate the association between serum uric acid level and fractional excretion of uric acid (FEUA) and simple renal cy...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ying Han, Mingliang Zhang, Junxi Lu, Lei Zhang, Junfeng Han, Fangya Zhao, Haibing Chen, Yuqian Bao, Weiping Jia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/208618f2718c4434b0050817bdc33250
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:208618f2718c4434b0050817bdc33250
record_format	dspace
spelling	oai:doaj.org-article:208618f2718c4434b0050817bdc332502021-12-02T16:06:16ZHyperuricemia and overexcretion of uric acid increase the risk of simple renal cysts in type 2 diabetes10.1038/s41598-017-04036-62045-2322https://doaj.org/article/208618f2718c4434b0050817bdc332502017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04036-6https://doaj.org/toc/2045-2322Abstract Previous studies have discussed the relationship between simple renal cysts (SRC) and serum uric acid level in healthy individuals. We performed a cross-sectional study to evaluate the association between serum uric acid level and fractional excretion of uric acid (FEUA) and simple renal cysts in males and postmenopausal females with type 2 diabetes. The overall prevalence of SRC was 18.1% in our population. SRC prevalence was significantly higher in hyperuricemic than normouricemic subjects (27.3% vs. 16.8%, P < 0.001). Subjects who overexcreted uric acid had a higher prevalence of SRC than underexcretors (total population: 21.6% vs. 16.3%; normouricemic subjects: 19.8% vs. 13.7%; hyperuricemic subjects: 50.0% vs. 22.7%, all P-values < 0.05). Hyperuricemia (odds ratio [OR] 1.824, 95% confidence interval [CI] 1.332–2.498, P < 0.001); FEUA (OR 1.046, 95% CI 1.002–1.091, P < 0.05); male gender (OR 1.922, 95% CI 1.489–2.480, P < 0.001); age (OR 1.049, 95% CI 1.035–1.064, P < 0.001); and albuminuria (OR 1.492, 95% CI 1.176–1.892, P < 0.01) were independent risk factors for SRC development. These findings suggested that hyperuricemia and high level of FEUA were both independent risk factors for SRC development in males and postmenopausal females with type 2 diabetes. Half of overproduction hyperuricemic patients had SRC.Ying HanMingliang ZhangJunxi LuLei ZhangJunfeng HanFangya ZhaoHaibing ChenYuqian BaoWeiping JiaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ying Han Mingliang Zhang Junxi Lu Lei Zhang Junfeng Han Fangya Zhao Haibing Chen Yuqian Bao Weiping Jia Hyperuricemia and overexcretion of uric acid increase the risk of simple renal cysts in type 2 diabetes
description	Abstract Previous studies have discussed the relationship between simple renal cysts (SRC) and serum uric acid level in healthy individuals. We performed a cross-sectional study to evaluate the association between serum uric acid level and fractional excretion of uric acid (FEUA) and simple renal cysts in males and postmenopausal females with type 2 diabetes. The overall prevalence of SRC was 18.1% in our population. SRC prevalence was significantly higher in hyperuricemic than normouricemic subjects (27.3% vs. 16.8%, P < 0.001). Subjects who overexcreted uric acid had a higher prevalence of SRC than underexcretors (total population: 21.6% vs. 16.3%; normouricemic subjects: 19.8% vs. 13.7%; hyperuricemic subjects: 50.0% vs. 22.7%, all P-values < 0.05). Hyperuricemia (odds ratio [OR] 1.824, 95% confidence interval [CI] 1.332–2.498, P < 0.001); FEUA (OR 1.046, 95% CI 1.002–1.091, P < 0.05); male gender (OR 1.922, 95% CI 1.489–2.480, P < 0.001); age (OR 1.049, 95% CI 1.035–1.064, P < 0.001); and albuminuria (OR 1.492, 95% CI 1.176–1.892, P < 0.01) were independent risk factors for SRC development. These findings suggested that hyperuricemia and high level of FEUA were both independent risk factors for SRC development in males and postmenopausal females with type 2 diabetes. Half of overproduction hyperuricemic patients had SRC.
format	article
author	Ying Han Mingliang Zhang Junxi Lu Lei Zhang Junfeng Han Fangya Zhao Haibing Chen Yuqian Bao Weiping Jia
author_facet	Ying Han Mingliang Zhang Junxi Lu Lei Zhang Junfeng Han Fangya Zhao Haibing Chen Yuqian Bao Weiping Jia
author_sort	Ying Han
title	Hyperuricemia and overexcretion of uric acid increase the risk of simple renal cysts in type 2 diabetes
title_short	Hyperuricemia and overexcretion of uric acid increase the risk of simple renal cysts in type 2 diabetes
title_full	Hyperuricemia and overexcretion of uric acid increase the risk of simple renal cysts in type 2 diabetes
title_fullStr	Hyperuricemia and overexcretion of uric acid increase the risk of simple renal cysts in type 2 diabetes
title_full_unstemmed	Hyperuricemia and overexcretion of uric acid increase the risk of simple renal cysts in type 2 diabetes
title_sort	hyperuricemia and overexcretion of uric acid increase the risk of simple renal cysts in type 2 diabetes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/208618f2718c4434b0050817bdc33250
work_keys_str_mv	AT yinghan hyperuricemiaandoverexcretionofuricacidincreasetheriskofsimplerenalcystsintype2diabetes AT mingliangzhang hyperuricemiaandoverexcretionofuricacidincreasetheriskofsimplerenalcystsintype2diabetes AT junxilu hyperuricemiaandoverexcretionofuricacidincreasetheriskofsimplerenalcystsintype2diabetes AT leizhang hyperuricemiaandoverexcretionofuricacidincreasetheriskofsimplerenalcystsintype2diabetes AT junfenghan hyperuricemiaandoverexcretionofuricacidincreasetheriskofsimplerenalcystsintype2diabetes AT fangyazhao hyperuricemiaandoverexcretionofuricacidincreasetheriskofsimplerenalcystsintype2diabetes AT haibingchen hyperuricemiaandoverexcretionofuricacidincreasetheriskofsimplerenalcystsintype2diabetes AT yuqianbao hyperuricemiaandoverexcretionofuricacidincreasetheriskofsimplerenalcystsintype2diabetes AT weipingjia hyperuricemiaandoverexcretionofuricacidincreasetheriskofsimplerenalcystsintype2diabetes
_version_	1718385010116919296

Hyperuricemia and overexcretion of uric acid increase the risk of simple renal cysts in type 2 diabetes

Ejemplares similares