Somatic alterations and mutational burden are potential predictive factors for metachronous development of early gastric cancer

Abstract The risk of developing metachronous gastric cancer (MGC) following curative endoscopic submucosal dissection (ESD) of early gastric cancer (EGC) remains even after eradicating Helicobacter pylori (HP) successfully. We screened initial EGC and adjacent non-cancerous mucosa ESD-resected speci...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kazuhiro Sakuta, Yu Sasaki, Yasuhiko Abe, Hidenori Sato, Masakuni Shoji, Takao Yaoita, Makoto Yagi, Naoko Mizumoto, Yusuke Onozato, Takashi Kon, Ayumi Koseki, Sonoko Sato, Ryoko Murakami, Yuki Miyano, Yoshiyuki Ueno
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/208876ad5a57449a9803c0d2a68fdd4b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:208876ad5a57449a9803c0d2a68fdd4b
record_format	dspace
spelling	oai:doaj.org-article:208876ad5a57449a9803c0d2a68fdd4b2021-12-02T13:58:11ZSomatic alterations and mutational burden are potential predictive factors for metachronous development of early gastric cancer10.1038/s41598-020-79195-02045-2322https://doaj.org/article/208876ad5a57449a9803c0d2a68fdd4b2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79195-0https://doaj.org/toc/2045-2322Abstract The risk of developing metachronous gastric cancer (MGC) following curative endoscopic submucosal dissection (ESD) of early gastric cancer (EGC) remains even after eradicating Helicobacter pylori (HP) successfully. We screened initial EGC and adjacent non-cancerous mucosa ESD-resected specimens for somatic variants of 409 cancer-related genes, assessing their mutational burden (MB) to predict molecular markers for metachronous post-ESD development. We compared variants between ten patients diagnosed with MGC more than 3 years after ESD and ten age-matched patients who did not have MGC developments after successful HP eradication. We found no significant background differences between the two groups. In adjacent non-cancerous mucosa, the MB tended to be higher in the patients with metachronous developments than in the others. Somatic genomic alterations of RECQL4, JAK3, ARID1A, and MAGI1 genes were significantly associated with MGC development. The criteria including both the MB and their variants, which had potential significant values for predicting MGC. In conclusion, combined of assessing specific somatic variants and MB may be useful for predicting MGC development. This study included a limited number of subjects; however, our novel findings may encourage further exploration of the significance of the molecular features of EGC that predict MGC development, thereby promoting focused follow-up strategies and helping elucidate the mechanisms.Kazuhiro SakutaYu SasakiYasuhiko AbeHidenori SatoMasakuni ShojiTakao YaoitaMakoto YagiNaoko MizumotoYusuke OnozatoTakashi KonAyumi KosekiSonoko SatoRyoko MurakamiYuki MiyanoYoshiyuki UenoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kazuhiro Sakuta Yu Sasaki Yasuhiko Abe Hidenori Sato Masakuni Shoji Takao Yaoita Makoto Yagi Naoko Mizumoto Yusuke Onozato Takashi Kon Ayumi Koseki Sonoko Sato Ryoko Murakami Yuki Miyano Yoshiyuki Ueno Somatic alterations and mutational burden are potential predictive factors for metachronous development of early gastric cancer
description	Abstract The risk of developing metachronous gastric cancer (MGC) following curative endoscopic submucosal dissection (ESD) of early gastric cancer (EGC) remains even after eradicating Helicobacter pylori (HP) successfully. We screened initial EGC and adjacent non-cancerous mucosa ESD-resected specimens for somatic variants of 409 cancer-related genes, assessing their mutational burden (MB) to predict molecular markers for metachronous post-ESD development. We compared variants between ten patients diagnosed with MGC more than 3 years after ESD and ten age-matched patients who did not have MGC developments after successful HP eradication. We found no significant background differences between the two groups. In adjacent non-cancerous mucosa, the MB tended to be higher in the patients with metachronous developments than in the others. Somatic genomic alterations of RECQL4, JAK3, ARID1A, and MAGI1 genes were significantly associated with MGC development. The criteria including both the MB and their variants, which had potential significant values for predicting MGC. In conclusion, combined of assessing specific somatic variants and MB may be useful for predicting MGC development. This study included a limited number of subjects; however, our novel findings may encourage further exploration of the significance of the molecular features of EGC that predict MGC development, thereby promoting focused follow-up strategies and helping elucidate the mechanisms.
format	article
author	Kazuhiro Sakuta Yu Sasaki Yasuhiko Abe Hidenori Sato Masakuni Shoji Takao Yaoita Makoto Yagi Naoko Mizumoto Yusuke Onozato Takashi Kon Ayumi Koseki Sonoko Sato Ryoko Murakami Yuki Miyano Yoshiyuki Ueno
author_facet	Kazuhiro Sakuta Yu Sasaki Yasuhiko Abe Hidenori Sato Masakuni Shoji Takao Yaoita Makoto Yagi Naoko Mizumoto Yusuke Onozato Takashi Kon Ayumi Koseki Sonoko Sato Ryoko Murakami Yuki Miyano Yoshiyuki Ueno
author_sort	Kazuhiro Sakuta
title	Somatic alterations and mutational burden are potential predictive factors for metachronous development of early gastric cancer
title_short	Somatic alterations and mutational burden are potential predictive factors for metachronous development of early gastric cancer
title_full	Somatic alterations and mutational burden are potential predictive factors for metachronous development of early gastric cancer
title_fullStr	Somatic alterations and mutational burden are potential predictive factors for metachronous development of early gastric cancer
title_full_unstemmed	Somatic alterations and mutational burden are potential predictive factors for metachronous development of early gastric cancer
title_sort	somatic alterations and mutational burden are potential predictive factors for metachronous development of early gastric cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/208876ad5a57449a9803c0d2a68fdd4b
work_keys_str_mv	AT kazuhirosakuta somaticalterationsandmutationalburdenarepotentialpredictivefactorsformetachronousdevelopmentofearlygastriccancer AT yusasaki somaticalterationsandmutationalburdenarepotentialpredictivefactorsformetachronousdevelopmentofearlygastriccancer AT yasuhikoabe somaticalterationsandmutationalburdenarepotentialpredictivefactorsformetachronousdevelopmentofearlygastriccancer AT hidenorisato somaticalterationsandmutationalburdenarepotentialpredictivefactorsformetachronousdevelopmentofearlygastriccancer AT masakunishoji somaticalterationsandmutationalburdenarepotentialpredictivefactorsformetachronousdevelopmentofearlygastriccancer AT takaoyaoita somaticalterationsandmutationalburdenarepotentialpredictivefactorsformetachronousdevelopmentofearlygastriccancer AT makotoyagi somaticalterationsandmutationalburdenarepotentialpredictivefactorsformetachronousdevelopmentofearlygastriccancer AT naokomizumoto somaticalterationsandmutationalburdenarepotentialpredictivefactorsformetachronousdevelopmentofearlygastriccancer AT yusukeonozato somaticalterationsandmutationalburdenarepotentialpredictivefactorsformetachronousdevelopmentofearlygastriccancer AT takashikon somaticalterationsandmutationalburdenarepotentialpredictivefactorsformetachronousdevelopmentofearlygastriccancer AT ayumikoseki somaticalterationsandmutationalburdenarepotentialpredictivefactorsformetachronousdevelopmentofearlygastriccancer AT sonokosato somaticalterationsandmutationalburdenarepotentialpredictivefactorsformetachronousdevelopmentofearlygastriccancer AT ryokomurakami somaticalterationsandmutationalburdenarepotentialpredictivefactorsformetachronousdevelopmentofearlygastriccancer AT yukimiyano somaticalterationsandmutationalburdenarepotentialpredictivefactorsformetachronousdevelopmentofearlygastriccancer AT yoshiyukiueno somaticalterationsandmutationalburdenarepotentialpredictivefactorsformetachronousdevelopmentofearlygastriccancer
_version_	1718392247132618752

Somatic alterations and mutational burden are potential predictive factors for metachronous development of early gastric cancer

Ejemplares similares