Cytoplasmic relaxation of active Eph controls ephrin shedding by ADAM10.

Cytoplasmic relaxation of active Eph controls ephrin shedding by ADAM10.

Release of cell surface-bound ligands by A-Disintegrin-And-Metalloprotease (ADAM) transmembrane metalloproteases is essential for signalling by cytokine, cell adhesion, and tyrosine kinase receptors. For Eph receptor ligands, it provides the switch between cell-cell adhesion and repulsion. Ligand sh...

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Autores principales: Peter W Janes, Sabine H Wimmer-Kleikamp, Achilleas S Frangakis, Kane Treble, Bettina Griesshaber, Ola Sabet, Markus Grabenbauer, Alice Y Ting, Paul Saftig, Philippe I Bastiaens, Martin Lackmann
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2009
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/208a197eb2a04790bf321370e02d3201
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