A multicenter, prospective, observational study to determine association of mesangial C1q deposition with renal outcomes in IgA nephropathy

Abstract It was reported that histopathologic lesions are risk factors for the progression of IgA Nephropathy (IgAN). The aim of this study was to investigate the relationships between mesangial deposition of C1q and renal outcomes in IgAN. 1071 patients with primary IgAN diagnosed by renal biopsy w...

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Autores principales:	Li Tan, Yi Tang, Gaiqin Pei, Zhengxia Zhong, Jiaxing Tan, Ling Zhou, Dongmei Wen, David Sheikh-Hamad, Wei Qin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/208fb6b695c24e189e1d1e0a867d6a42
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spelling	oai:doaj.org-article:208fb6b695c24e189e1d1e0a867d6a422021-12-02T13:20:13ZA multicenter, prospective, observational study to determine association of mesangial C1q deposition with renal outcomes in IgA nephropathy10.1038/s41598-021-84715-72045-2322https://doaj.org/article/208fb6b695c24e189e1d1e0a867d6a422021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84715-7https://doaj.org/toc/2045-2322Abstract It was reported that histopathologic lesions are risk factors for the progression of IgA Nephropathy (IgAN). The aim of this study was to investigate the relationships between mesangial deposition of C1q and renal outcomes in IgAN. 1071 patients with primary IgAN diagnosed by renal biopsy were enrolled in multiple study centers form January 2013 to January 2017. Patients were divided into two groups: C1q-positive and C1q-negative. Using a 1: 4 propensity score matching (PSM) method identifying age, gender, and treatment modality to minimize confounding factors, 580 matched (out of 926) C1q-negative patients were compared with 145 C1q-positive patients to evaluate severity of baseline clinicopathological features and renal outcome. Kaplan–Meier and Cox proportional hazards analyses were performed to determine whether mesangial C1q deposition is associated with renal outcomes in IgAN. During the follow-up period (41.89 ± 22.85 months), 54 (9.31%) patients in the C1q negative group and 23 (15.86%) patients in C1q positive group reached the endpoint (50% decline of eGFR and/or ESRD or death) respectively (p = 0.01) in the matched cohort. Significantly more patients in C1q negative group achieved complete or partial remission during the follow up period (P = 0.003) both before and after PSM. Three, 5 and 7-year renal survival rates in C1q-positive patients were significantly lower than C1q-negative patients in either unmatched cohort or matched cohort (all p < 0.05). Furthermore, multivariate Cox regression analysis showed that independent risk factors influencing renal survival included Scr, urinary protein, T1-T2 lesion and C1q deposition. Mesangial C1q deposition is a predictor of poor renal survival in IgA nephropathy. Trial registration TCTR, TCTR20140515001. Registered May 15, 2014, http://www.clinicaltrials.in.th/index.php?tp=regtrials&menu=trialsearch&smenu=fulltext&task=search&task2=view1&id=1074 .Li TanYi TangGaiqin PeiZhengxia ZhongJiaxing TanLing ZhouDongmei WenDavid Sheikh-HamadWei QinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Li Tan Yi Tang Gaiqin Pei Zhengxia Zhong Jiaxing Tan Ling Zhou Dongmei Wen David Sheikh-Hamad Wei Qin A multicenter, prospective, observational study to determine association of mesangial C1q deposition with renal outcomes in IgA nephropathy
description	Abstract It was reported that histopathologic lesions are risk factors for the progression of IgA Nephropathy (IgAN). The aim of this study was to investigate the relationships between mesangial deposition of C1q and renal outcomes in IgAN. 1071 patients with primary IgAN diagnosed by renal biopsy were enrolled in multiple study centers form January 2013 to January 2017. Patients were divided into two groups: C1q-positive and C1q-negative. Using a 1: 4 propensity score matching (PSM) method identifying age, gender, and treatment modality to minimize confounding factors, 580 matched (out of 926) C1q-negative patients were compared with 145 C1q-positive patients to evaluate severity of baseline clinicopathological features and renal outcome. Kaplan–Meier and Cox proportional hazards analyses were performed to determine whether mesangial C1q deposition is associated with renal outcomes in IgAN. During the follow-up period (41.89 ± 22.85 months), 54 (9.31%) patients in the C1q negative group and 23 (15.86%) patients in C1q positive group reached the endpoint (50% decline of eGFR and/or ESRD or death) respectively (p = 0.01) in the matched cohort. Significantly more patients in C1q negative group achieved complete or partial remission during the follow up period (P = 0.003) both before and after PSM. Three, 5 and 7-year renal survival rates in C1q-positive patients were significantly lower than C1q-negative patients in either unmatched cohort or matched cohort (all p < 0.05). Furthermore, multivariate Cox regression analysis showed that independent risk factors influencing renal survival included Scr, urinary protein, T1-T2 lesion and C1q deposition. Mesangial C1q deposition is a predictor of poor renal survival in IgA nephropathy. Trial registration TCTR, TCTR20140515001. Registered May 15, 2014, http://www.clinicaltrials.in.th/index.php?tp=regtrials&menu=trialsearch&smenu=fulltext&task=search&task2=view1&id=1074 .
format	article
author	Li Tan Yi Tang Gaiqin Pei Zhengxia Zhong Jiaxing Tan Ling Zhou Dongmei Wen David Sheikh-Hamad Wei Qin
author_facet	Li Tan Yi Tang Gaiqin Pei Zhengxia Zhong Jiaxing Tan Ling Zhou Dongmei Wen David Sheikh-Hamad Wei Qin
author_sort	Li Tan
title	A multicenter, prospective, observational study to determine association of mesangial C1q deposition with renal outcomes in IgA nephropathy
title_short	A multicenter, prospective, observational study to determine association of mesangial C1q deposition with renal outcomes in IgA nephropathy
title_full	A multicenter, prospective, observational study to determine association of mesangial C1q deposition with renal outcomes in IgA nephropathy
title_fullStr	A multicenter, prospective, observational study to determine association of mesangial C1q deposition with renal outcomes in IgA nephropathy
title_full_unstemmed	A multicenter, prospective, observational study to determine association of mesangial C1q deposition with renal outcomes in IgA nephropathy
title_sort	multicenter, prospective, observational study to determine association of mesangial c1q deposition with renal outcomes in iga nephropathy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/208fb6b695c24e189e1d1e0a867d6a42
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A multicenter, prospective, observational study to determine association of mesangial C1q deposition with renal outcomes in IgA nephropathy

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