Synthetic Symbiosis under Environmental Disturbances

ABSTRACT By virtue of complex ecologies, the behavior of mutualisms is challenging to study and nearly impossible to predict. However, laboratory engineered mutualistic systems facilitate a better understanding of their bare essentials. On the basis of an abstract theoretical model and a modifiable...

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Autores principales:	Jai A. Denton, Chaitanya S. Gokhale
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	nonlinear interactions environmental change mathematical modeling symbiosis synthetic biology Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/2094c85c116f47cfb6d861c5b648662b
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spelling	oai:doaj.org-article:2094c85c116f47cfb6d861c5b648662b2021-12-02T19:46:20ZSynthetic Symbiosis under Environmental Disturbances10.1128/mSystems.00187-202379-5077https://doaj.org/article/2094c85c116f47cfb6d861c5b648662b2020-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00187-20https://doaj.org/toc/2379-5077ABSTRACT By virtue of complex ecologies, the behavior of mutualisms is challenging to study and nearly impossible to predict. However, laboratory engineered mutualistic systems facilitate a better understanding of their bare essentials. On the basis of an abstract theoretical model and a modifiable experimental yeast system, we explore the environmental limits of self-organized cooperation based on the production and use of specific metabolites. We develop and test the assumptions and stability of the theoretical model by leveraging the simplicity of an artificial yeast system as a simple model of mutualism. We examine how one-off, recurring, and permanent changes to an ecological niche affect a cooperative interaction and change the population composition of an engineered mutualistic system. Moreover, we explore how the cellular burden of cooperating influences the stability of mutualism and how environmental changes shape this stability. Our results highlight the fragility of mutualisms and suggest interventions, including those that rely on the use of synthetic biology. IMPORTANCE The power of synthetic biology is immense. Will it, however, be able to withstand the environmental pressures once released in the wild. As new technologies aim to do precisely the same, we use a much simpler model to test mathematically the effect of a changing environment on a synthetic biological system. We assume that the system is successful if it maintains proportions close to what we observe in the laboratory. Extreme deviations from the expected equilibrium are possible as the environment changes. Our study provides the conditions and the designer specifications which may need to be incorporated in the synthetic systems if we want such “ecoblocs” to survive in the wild.Jai A. DentonChaitanya S. GokhaleAmerican Society for Microbiologyarticlenonlinear interactionsenvironmental changemathematical modelingsymbiosissynthetic biologyMicrobiologyQR1-502ENmSystems, Vol 5, Iss 3 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	nonlinear interactions environmental change mathematical modeling symbiosis synthetic biology Microbiology QR1-502
spellingShingle	nonlinear interactions environmental change mathematical modeling symbiosis synthetic biology Microbiology QR1-502 Jai A. Denton Chaitanya S. Gokhale Synthetic Symbiosis under Environmental Disturbances
description	ABSTRACT By virtue of complex ecologies, the behavior of mutualisms is challenging to study and nearly impossible to predict. However, laboratory engineered mutualistic systems facilitate a better understanding of their bare essentials. On the basis of an abstract theoretical model and a modifiable experimental yeast system, we explore the environmental limits of self-organized cooperation based on the production and use of specific metabolites. We develop and test the assumptions and stability of the theoretical model by leveraging the simplicity of an artificial yeast system as a simple model of mutualism. We examine how one-off, recurring, and permanent changes to an ecological niche affect a cooperative interaction and change the population composition of an engineered mutualistic system. Moreover, we explore how the cellular burden of cooperating influences the stability of mutualism and how environmental changes shape this stability. Our results highlight the fragility of mutualisms and suggest interventions, including those that rely on the use of synthetic biology. IMPORTANCE The power of synthetic biology is immense. Will it, however, be able to withstand the environmental pressures once released in the wild. As new technologies aim to do precisely the same, we use a much simpler model to test mathematically the effect of a changing environment on a synthetic biological system. We assume that the system is successful if it maintains proportions close to what we observe in the laboratory. Extreme deviations from the expected equilibrium are possible as the environment changes. Our study provides the conditions and the designer specifications which may need to be incorporated in the synthetic systems if we want such “ecoblocs” to survive in the wild.
format	article
author	Jai A. Denton Chaitanya S. Gokhale
author_facet	Jai A. Denton Chaitanya S. Gokhale
author_sort	Jai A. Denton
title	Synthetic Symbiosis under Environmental Disturbances
title_short	Synthetic Symbiosis under Environmental Disturbances
title_full	Synthetic Symbiosis under Environmental Disturbances
title_fullStr	Synthetic Symbiosis under Environmental Disturbances
title_full_unstemmed	Synthetic Symbiosis under Environmental Disturbances
title_sort	synthetic symbiosis under environmental disturbances
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/2094c85c116f47cfb6d861c5b648662b
work_keys_str_mv	AT jaiadenton syntheticsymbiosisunderenvironmentaldisturbances AT chaitanyasgokhale syntheticsymbiosisunderenvironmentaldisturbances
_version_	1718376012931137536

Synthetic Symbiosis under Environmental Disturbances

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