Echocardiographic Patterns of Left Ventricular Diastolic Function in Cardiac Amyloidosis: An Updated Evaluation

Aims: Multimodal imaging has allowed cardiac amyloidosis (CA) to be increasingly recognised as a treatable cause of heart failure with preserved ejection fraction, but its prognosis remains poor due to late diagnosis. To assess the left ventricular diastolic function (LVDF) patterns in a large conte...

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Autores principales:	Silvia Oghina, Wulfran Bougouin, Mounira Kharoubi, Louis Bonnefous, Arnault Galat, Soulef Guendouz, Mélanie Bezard, Fabien Le Bras, Jean-François Deux, Emmanuel Itti, Anissa Moktefi, Pascale Fanen, Emmanuel Teiger, Dania Mohty, Thibaud Damy, Diane Bodez
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cardiac amyloidosis heart failure diastolic function echocardiography guidelines Medicine R
Acceso en línea:	https://doaj.org/article/2096263e9e4e4aaf977ee800b5339161
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spelling	oai:doaj.org-article:2096263e9e4e4aaf977ee800b53391612021-11-11T17:32:33ZEchocardiographic Patterns of Left Ventricular Diastolic Function in Cardiac Amyloidosis: An Updated Evaluation10.3390/jcm102148882077-0383https://doaj.org/article/2096263e9e4e4aaf977ee800b53391612021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/4888https://doaj.org/toc/2077-0383Aims: Multimodal imaging has allowed cardiac amyloidosis (CA) to be increasingly recognised as a treatable cause of heart failure with preserved ejection fraction, but its prognosis remains poor due to late diagnosis. To assess the left ventricular diastolic function (LVDF) patterns in a large contemporary CA cohort according to the current recommendations and to identify their determinants. Methods and Results: We conducted a monocentric, observational study on a cohort of CA patients from a tertiary CA referral centre. Diastolic function was analysed using standard echocardiography and clinical, laboratory and survival parameters were collected. Four hundred and sixty-four patients with one of the three main type of CA were included: 41% had grade III diastolic dysfunction (restrictive mitral pattern), 25% had grade II diastolic dysfunction, and 25% had grade I diastolic dysfunction; 9% were unclassified. No difference was found between the main CA types. After multivariate analyses, grades II and III were independently associated with dyspnoea, elevated NT-proBNP, cardiac infiltration and systolic dysfunction (global longitudinal strain). Grade I patients had a better prognosis. Conclusions: All LVDF patterns can be observed in CA. One quarter of CA patients have grade I LVDF, reflecting the emergence of earlier stage-related phenotypes with a better prognosis.Silvia OghinaWulfran BougouinMounira KharoubiLouis BonnefousArnault GalatSoulef GuendouzMélanie BezardFabien Le BrasJean-François DeuxEmmanuel IttiAnissa MoktefiPascale FanenEmmanuel TeigerDania MohtyThibaud DamyDiane BodezMDPI AGarticlecardiac amyloidosisheart failurediastolic functionechocardiographyguidelinesMedicineRENJournal of Clinical Medicine, Vol 10, Iss 4888, p 4888 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cardiac amyloidosis heart failure diastolic function echocardiography guidelines Medicine R
spellingShingle	cardiac amyloidosis heart failure diastolic function echocardiography guidelines Medicine R Silvia Oghina Wulfran Bougouin Mounira Kharoubi Louis Bonnefous Arnault Galat Soulef Guendouz Mélanie Bezard Fabien Le Bras Jean-François Deux Emmanuel Itti Anissa Moktefi Pascale Fanen Emmanuel Teiger Dania Mohty Thibaud Damy Diane Bodez Echocardiographic Patterns of Left Ventricular Diastolic Function in Cardiac Amyloidosis: An Updated Evaluation
description	Aims: Multimodal imaging has allowed cardiac amyloidosis (CA) to be increasingly recognised as a treatable cause of heart failure with preserved ejection fraction, but its prognosis remains poor due to late diagnosis. To assess the left ventricular diastolic function (LVDF) patterns in a large contemporary CA cohort according to the current recommendations and to identify their determinants. Methods and Results: We conducted a monocentric, observational study on a cohort of CA patients from a tertiary CA referral centre. Diastolic function was analysed using standard echocardiography and clinical, laboratory and survival parameters were collected. Four hundred and sixty-four patients with one of the three main type of CA were included: 41% had grade III diastolic dysfunction (restrictive mitral pattern), 25% had grade II diastolic dysfunction, and 25% had grade I diastolic dysfunction; 9% were unclassified. No difference was found between the main CA types. After multivariate analyses, grades II and III were independently associated with dyspnoea, elevated NT-proBNP, cardiac infiltration and systolic dysfunction (global longitudinal strain). Grade I patients had a better prognosis. Conclusions: All LVDF patterns can be observed in CA. One quarter of CA patients have grade I LVDF, reflecting the emergence of earlier stage-related phenotypes with a better prognosis.
format	article
author	Silvia Oghina Wulfran Bougouin Mounira Kharoubi Louis Bonnefous Arnault Galat Soulef Guendouz Mélanie Bezard Fabien Le Bras Jean-François Deux Emmanuel Itti Anissa Moktefi Pascale Fanen Emmanuel Teiger Dania Mohty Thibaud Damy Diane Bodez
author_facet	Silvia Oghina Wulfran Bougouin Mounira Kharoubi Louis Bonnefous Arnault Galat Soulef Guendouz Mélanie Bezard Fabien Le Bras Jean-François Deux Emmanuel Itti Anissa Moktefi Pascale Fanen Emmanuel Teiger Dania Mohty Thibaud Damy Diane Bodez
author_sort	Silvia Oghina
title	Echocardiographic Patterns of Left Ventricular Diastolic Function in Cardiac Amyloidosis: An Updated Evaluation
title_short	Echocardiographic Patterns of Left Ventricular Diastolic Function in Cardiac Amyloidosis: An Updated Evaluation
title_full	Echocardiographic Patterns of Left Ventricular Diastolic Function in Cardiac Amyloidosis: An Updated Evaluation
title_fullStr	Echocardiographic Patterns of Left Ventricular Diastolic Function in Cardiac Amyloidosis: An Updated Evaluation
title_full_unstemmed	Echocardiographic Patterns of Left Ventricular Diastolic Function in Cardiac Amyloidosis: An Updated Evaluation
title_sort	echocardiographic patterns of left ventricular diastolic function in cardiac amyloidosis: an updated evaluation
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2096263e9e4e4aaf977ee800b5339161
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Echocardiographic Patterns of Left Ventricular Diastolic Function in Cardiac Amyloidosis: An Updated Evaluation

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