Semen parameters in men recovered from COVID-19: a systematic review and meta-analysis

Abstract Background The novel beta-coronavirus disease (COVID-19) has infected millions of people globally with high risk among males than females. However, the effect of COVID-19 andrology is still a subject of dispute. We planned to analyze the overall consequences of COVID-19 on semen parameters...

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Autores principales:	Sagar Tiwari, Niranjan KC, Sajan Thapa, Anuja Ghimire, Sanjeev Bijukchhe, Guru Sharan Sah, Ronny Isnuwardana
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	COVID-19 Infertility Male Meta-analysis Semen SARS-CoV-2 Medicine (General) R5-920 Reproduction QH471-489
Acceso en línea:	https://doaj.org/article/209aad4ae53a48c897c34cb2093f86c5
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spelling	oai:doaj.org-article:209aad4ae53a48c897c34cb2093f86c52021-12-05T12:07:55ZSemen parameters in men recovered from COVID-19: a systematic review and meta-analysis10.1186/s43043-021-00089-w2090-3251https://doaj.org/article/209aad4ae53a48c897c34cb2093f86c52021-12-01T00:00:00Zhttps://doi.org/10.1186/s43043-021-00089-whttps://doaj.org/toc/2090-3251Abstract Background The novel beta-coronavirus disease (COVID-19) has infected millions of people globally with high risk among males than females. However, the effect of COVID-19 andrology is still a subject of dispute. We planned to analyze the overall consequences of COVID-19 on semen parameters and male sex hormones. Main text Systematic search was performed on MEDLINE and Scopus database until 11 June 2021. We included observational studies, which reported mean ± standard deviation of the semen parameters and serum sex hormones of those reproductive-aged males recovered from COVID-19 and controls who did not suffered from COVID-19. We used Random-effect model to pool the studies, as heterogeneity was present. The Q test and I 2 evaluated heterogeneity. All articles were assessed with their quality and publication bias. We assessed 966 articles for eligibility and found seven eligible studies. These 7 studies included 934 participants with mean age 37.34 ± 10.5 years. Random-effect model meta-analysis showed that men who recovered from COVID-19 had semen parameters less than those who had not suffered from COVID-19. The overall mean difference (MD) [95% confidence interval (CI)] in semen volume, sperm concentration, sperm number, and progressive sperm motility was − 0.20 (− 0.45, 0.05) ml, − 16.59 (− 34.82, 1.65) millions/ml, − 45.44 (− 84.56, − 6.31) millions per ejaculate, − 1.73 (− 8.20, 4.75) percentage respectively. Considering sex hormones, luteinizing hormone and prolactin levels were higher among those recovered with a significant MD (95% CI) of 3.47 (1.59, 5.35)U l−1 and 3.21 (1.71, 4.72)ng ml−1 respectively. Conclusion We found that COVID-19 affects both semen parameters and sexual hormones. However, the mechanism for testicular involvement remains doubtful. Trial registration PROSPERO CRD42021259445Sagar TiwariNiranjan KCSajan ThapaAnuja GhimireSanjeev BijukchheGuru Sharan SahRonny IsnuwardanaSpringerOpenarticleCOVID-19InfertilityMaleMeta-analysisSemenSARS-CoV-2Medicine (General)R5-920ReproductionQH471-489ENMiddle East Fertility Society Journal, Vol 26, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 Infertility Male Meta-analysis Semen SARS-CoV-2 Medicine (General) R5-920 Reproduction QH471-489
spellingShingle	COVID-19 Infertility Male Meta-analysis Semen SARS-CoV-2 Medicine (General) R5-920 Reproduction QH471-489 Sagar Tiwari Niranjan KC Sajan Thapa Anuja Ghimire Sanjeev Bijukchhe Guru Sharan Sah Ronny Isnuwardana Semen parameters in men recovered from COVID-19: a systematic review and meta-analysis
description	Abstract Background The novel beta-coronavirus disease (COVID-19) has infected millions of people globally with high risk among males than females. However, the effect of COVID-19 andrology is still a subject of dispute. We planned to analyze the overall consequences of COVID-19 on semen parameters and male sex hormones. Main text Systematic search was performed on MEDLINE and Scopus database until 11 June 2021. We included observational studies, which reported mean ± standard deviation of the semen parameters and serum sex hormones of those reproductive-aged males recovered from COVID-19 and controls who did not suffered from COVID-19. We used Random-effect model to pool the studies, as heterogeneity was present. The Q test and I 2 evaluated heterogeneity. All articles were assessed with their quality and publication bias. We assessed 966 articles for eligibility and found seven eligible studies. These 7 studies included 934 participants with mean age 37.34 ± 10.5 years. Random-effect model meta-analysis showed that men who recovered from COVID-19 had semen parameters less than those who had not suffered from COVID-19. The overall mean difference (MD) [95% confidence interval (CI)] in semen volume, sperm concentration, sperm number, and progressive sperm motility was − 0.20 (− 0.45, 0.05) ml, − 16.59 (− 34.82, 1.65) millions/ml, − 45.44 (− 84.56, − 6.31) millions per ejaculate, − 1.73 (− 8.20, 4.75) percentage respectively. Considering sex hormones, luteinizing hormone and prolactin levels were higher among those recovered with a significant MD (95% CI) of 3.47 (1.59, 5.35)U l−1 and 3.21 (1.71, 4.72)ng ml−1 respectively. Conclusion We found that COVID-19 affects both semen parameters and sexual hormones. However, the mechanism for testicular involvement remains doubtful. Trial registration PROSPERO CRD42021259445
format	article
author	Sagar Tiwari Niranjan KC Sajan Thapa Anuja Ghimire Sanjeev Bijukchhe Guru Sharan Sah Ronny Isnuwardana
author_facet	Sagar Tiwari Niranjan KC Sajan Thapa Anuja Ghimire Sanjeev Bijukchhe Guru Sharan Sah Ronny Isnuwardana
author_sort	Sagar Tiwari
title	Semen parameters in men recovered from COVID-19: a systematic review and meta-analysis
title_short	Semen parameters in men recovered from COVID-19: a systematic review and meta-analysis
title_full	Semen parameters in men recovered from COVID-19: a systematic review and meta-analysis
title_fullStr	Semen parameters in men recovered from COVID-19: a systematic review and meta-analysis
title_full_unstemmed	Semen parameters in men recovered from COVID-19: a systematic review and meta-analysis
title_sort	semen parameters in men recovered from covid-19: a systematic review and meta-analysis
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/209aad4ae53a48c897c34cb2093f86c5
work_keys_str_mv	AT sagartiwari semenparametersinmenrecoveredfromcovid19asystematicreviewandmetaanalysis AT niranjankc semenparametersinmenrecoveredfromcovid19asystematicreviewandmetaanalysis AT sajanthapa semenparametersinmenrecoveredfromcovid19asystematicreviewandmetaanalysis AT anujaghimire semenparametersinmenrecoveredfromcovid19asystematicreviewandmetaanalysis AT sanjeevbijukchhe semenparametersinmenrecoveredfromcovid19asystematicreviewandmetaanalysis AT gurusharansah semenparametersinmenrecoveredfromcovid19asystematicreviewandmetaanalysis AT ronnyisnuwardana semenparametersinmenrecoveredfromcovid19asystematicreviewandmetaanalysis
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Semen parameters in men recovered from COVID-19: a systematic review and meta-analysis

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