Roseburia intestinalis: A Beneficial Gut Organism From the Discoveries in Genus and Species

Roseburia intestinalis is an anaerobic, Gram-positive, slightly curved rod-shaped flagellated bacterium that produces butyrate in the colon. R. intestinalis has been shown to prevent intestinal inflammation and maintain energy homeostasis by producing metabolites. Evidence shows that this bacterium...

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Autores principales:	Kai Nie, Kejia Ma, Weiwei Luo, Zhaohua Shen, Zhenyu Yang, Mengwei Xiao, Ting Tong, Yuanyuan Yang, Xiaoyan Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Roseburia Roseburia intestinalis probiotic inflammatory bowel disease (IBD) microbiome Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/209ac82b7d0e4a4b8e2a77339a4a7a0d
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spelling	oai:doaj.org-article:209ac82b7d0e4a4b8e2a77339a4a7a0d2021-11-30T10:16:00ZRoseburia intestinalis: A Beneficial Gut Organism From the Discoveries in Genus and Species2235-298810.3389/fcimb.2021.757718https://doaj.org/article/209ac82b7d0e4a4b8e2a77339a4a7a0d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcimb.2021.757718/fullhttps://doaj.org/toc/2235-2988Roseburia intestinalis is an anaerobic, Gram-positive, slightly curved rod-shaped flagellated bacterium that produces butyrate in the colon. R. intestinalis has been shown to prevent intestinal inflammation and maintain energy homeostasis by producing metabolites. Evidence shows that this bacterium contributes to various diseases, such as inflammatory bowel disease, type 2 diabetes mellitus, antiphospholipid syndrome, and atherosclerosis. This review reveals the potential therapeutic role of R. intestinalis in human diseases. Patients with inflammatory bowel disease exhibit significant changes in R. intestinalis abundance, and they may benefit a lot from modulations targeting R. intestinalis. The data reviewed here demonstrate that R. intestinalis plays its role in regulating barrier homeostasis, immune cells, and cytokine release through its metabolite butyrate, flagellin and other. Recent advancements in the application of primary culture technology, culture omics, single-cell sequencing, and metabonomics technology have improved research on Roseburia and revealed the benefits of this bacterium in human health and disease treatment.Kai NieKai NieKejia MaKejia MaWeiwei LuoWeiwei LuoZhaohua ShenZhaohua ShenZhenyu YangZhenyu YangMengwei XiaoMengwei XiaoTing TongTing TongYuanyuan YangYuanyuan YangXiaoyan WangXiaoyan WangFrontiers Media S.A.articleRoseburiaRoseburia intestinalisprobioticinflammatory bowel disease (IBD)microbiomeMicrobiologyQR1-502ENFrontiers in Cellular and Infection Microbiology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Roseburia Roseburia intestinalis probiotic inflammatory bowel disease (IBD) microbiome Microbiology QR1-502
spellingShingle	Roseburia Roseburia intestinalis probiotic inflammatory bowel disease (IBD) microbiome Microbiology QR1-502 Kai Nie Kai Nie Kejia Ma Kejia Ma Weiwei Luo Weiwei Luo Zhaohua Shen Zhaohua Shen Zhenyu Yang Zhenyu Yang Mengwei Xiao Mengwei Xiao Ting Tong Ting Tong Yuanyuan Yang Yuanyuan Yang Xiaoyan Wang Xiaoyan Wang Roseburia intestinalis: A Beneficial Gut Organism From the Discoveries in Genus and Species
description	Roseburia intestinalis is an anaerobic, Gram-positive, slightly curved rod-shaped flagellated bacterium that produces butyrate in the colon. R. intestinalis has been shown to prevent intestinal inflammation and maintain energy homeostasis by producing metabolites. Evidence shows that this bacterium contributes to various diseases, such as inflammatory bowel disease, type 2 diabetes mellitus, antiphospholipid syndrome, and atherosclerosis. This review reveals the potential therapeutic role of R. intestinalis in human diseases. Patients with inflammatory bowel disease exhibit significant changes in R. intestinalis abundance, and they may benefit a lot from modulations targeting R. intestinalis. The data reviewed here demonstrate that R. intestinalis plays its role in regulating barrier homeostasis, immune cells, and cytokine release through its metabolite butyrate, flagellin and other. Recent advancements in the application of primary culture technology, culture omics, single-cell sequencing, and metabonomics technology have improved research on Roseburia and revealed the benefits of this bacterium in human health and disease treatment.
format	article
author	Kai Nie Kai Nie Kejia Ma Kejia Ma Weiwei Luo Weiwei Luo Zhaohua Shen Zhaohua Shen Zhenyu Yang Zhenyu Yang Mengwei Xiao Mengwei Xiao Ting Tong Ting Tong Yuanyuan Yang Yuanyuan Yang Xiaoyan Wang Xiaoyan Wang
author_facet	Kai Nie Kai Nie Kejia Ma Kejia Ma Weiwei Luo Weiwei Luo Zhaohua Shen Zhaohua Shen Zhenyu Yang Zhenyu Yang Mengwei Xiao Mengwei Xiao Ting Tong Ting Tong Yuanyuan Yang Yuanyuan Yang Xiaoyan Wang Xiaoyan Wang
author_sort	Kai Nie
title	Roseburia intestinalis: A Beneficial Gut Organism From the Discoveries in Genus and Species
title_short	Roseburia intestinalis: A Beneficial Gut Organism From the Discoveries in Genus and Species
title_full	Roseburia intestinalis: A Beneficial Gut Organism From the Discoveries in Genus and Species
title_fullStr	Roseburia intestinalis: A Beneficial Gut Organism From the Discoveries in Genus and Species
title_full_unstemmed	Roseburia intestinalis: A Beneficial Gut Organism From the Discoveries in Genus and Species
title_sort	roseburia intestinalis: a beneficial gut organism from the discoveries in genus and species
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/209ac82b7d0e4a4b8e2a77339a4a7a0d
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Roseburia intestinalis: A Beneficial Gut Organism From the Discoveries in Genus and Species

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