ICAM-1-carrying targeted nano contrast agent for evaluating inflammatory injury in rabbits with atherosclerosis

Abstract To investigate the feasibility of using ICAM-1-targeted nano ultrasonic contrast to evaluate the degree of inflammatory injury at different stages in the abdominal aorta of rabbits with atherosclerosis (AS). Twenty-five experimental rabbits were assigned to five groups: the control group (A...

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Autores principales:	Ping Li, Lin Jin, Lan Feng, Yingchun Wang, Rong Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/209c9542dc404c66abe45c56eb110e85
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spelling	oai:doaj.org-article:209c9542dc404c66abe45c56eb110e852021-12-02T18:51:01ZICAM-1-carrying targeted nano contrast agent for evaluating inflammatory injury in rabbits with atherosclerosis10.1038/s41598-021-96042-y2045-2322https://doaj.org/article/209c9542dc404c66abe45c56eb110e852021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96042-yhttps://doaj.org/toc/2045-2322Abstract To investigate the feasibility of using ICAM-1-targeted nano ultrasonic contrast to evaluate the degree of inflammatory injury at different stages in the abdominal aorta of rabbits with atherosclerosis (AS). Twenty-five experimental rabbits were assigned to five groups: the control group (A); the week-4 after modeling group (B); the week-8 after modeling group (C); the week-12 after modeling group (D); the week-16 after modeling group (E). All groups were given 2D ultrasonography, conventional ultrasonic contrast (SonoVue), and ICAM-1-targeted nano ultrasonic contrast, respectively. Signal intensity of vascular perfusion was evaluated. Signal intensity of ICAM-1-targeted nano ultrasonic contrast was substantially enhanced and prolonged in the vascular wall of the abdominal bubble aorta increased in B, C, D, and E groups (all P < 0.05). A positive linear correlation between intensity and the expression of ICAM-1 (r = 0.895, P < 0.001). The intensity of outer membrane was enhanced from week 4 to week 12, and both the intima-media membrane and outer membrane were enhanced with double-layer parallel echo at week 16, which was in line with the progression of atherosclerotic plaque inflammatory injury. ICAM-1-targeted nano contrast agent would be possibly a novel non-invasive molecular imaging method for plaque inflammatory injury and site high expression of specific adhesion molecules in early atherosclerotic lesions.Ping LiLin JinLan FengYingchun WangRong YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ping Li Lin Jin Lan Feng Yingchun Wang Rong Yang ICAM-1-carrying targeted nano contrast agent for evaluating inflammatory injury in rabbits with atherosclerosis
description	Abstract To investigate the feasibility of using ICAM-1-targeted nano ultrasonic contrast to evaluate the degree of inflammatory injury at different stages in the abdominal aorta of rabbits with atherosclerosis (AS). Twenty-five experimental rabbits were assigned to five groups: the control group (A); the week-4 after modeling group (B); the week-8 after modeling group (C); the week-12 after modeling group (D); the week-16 after modeling group (E). All groups were given 2D ultrasonography, conventional ultrasonic contrast (SonoVue), and ICAM-1-targeted nano ultrasonic contrast, respectively. Signal intensity of vascular perfusion was evaluated. Signal intensity of ICAM-1-targeted nano ultrasonic contrast was substantially enhanced and prolonged in the vascular wall of the abdominal bubble aorta increased in B, C, D, and E groups (all P < 0.05). A positive linear correlation between intensity and the expression of ICAM-1 (r = 0.895, P < 0.001). The intensity of outer membrane was enhanced from week 4 to week 12, and both the intima-media membrane and outer membrane were enhanced with double-layer parallel echo at week 16, which was in line with the progression of atherosclerotic plaque inflammatory injury. ICAM-1-targeted nano contrast agent would be possibly a novel non-invasive molecular imaging method for plaque inflammatory injury and site high expression of specific adhesion molecules in early atherosclerotic lesions.
format	article
author	Ping Li Lin Jin Lan Feng Yingchun Wang Rong Yang
author_facet	Ping Li Lin Jin Lan Feng Yingchun Wang Rong Yang
author_sort	Ping Li
title	ICAM-1-carrying targeted nano contrast agent for evaluating inflammatory injury in rabbits with atherosclerosis
title_short	ICAM-1-carrying targeted nano contrast agent for evaluating inflammatory injury in rabbits with atherosclerosis
title_full	ICAM-1-carrying targeted nano contrast agent for evaluating inflammatory injury in rabbits with atherosclerosis
title_fullStr	ICAM-1-carrying targeted nano contrast agent for evaluating inflammatory injury in rabbits with atherosclerosis
title_full_unstemmed	ICAM-1-carrying targeted nano contrast agent for evaluating inflammatory injury in rabbits with atherosclerosis
title_sort	icam-1-carrying targeted nano contrast agent for evaluating inflammatory injury in rabbits with atherosclerosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/209c9542dc404c66abe45c56eb110e85
work_keys_str_mv	AT pingli icam1carryingtargetednanocontrastagentforevaluatinginflammatoryinjuryinrabbitswithatherosclerosis AT linjin icam1carryingtargetednanocontrastagentforevaluatinginflammatoryinjuryinrabbitswithatherosclerosis AT lanfeng icam1carryingtargetednanocontrastagentforevaluatinginflammatoryinjuryinrabbitswithatherosclerosis AT yingchunwang icam1carryingtargetednanocontrastagentforevaluatinginflammatoryinjuryinrabbitswithatherosclerosis AT rongyang icam1carryingtargetednanocontrastagentforevaluatinginflammatoryinjuryinrabbitswithatherosclerosis
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ICAM-1-carrying targeted nano contrast agent for evaluating inflammatory injury in rabbits with atherosclerosis

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