Nanoparticle-labeled stem cells: a novel therapeutic vehicle

Abir O El-Sadik1, Afaf El-Ansary2, Sherif M Sabry31Stem Cell Unit, Anatomy Department, College of Medicine, Health Science Colleges; 2Biochemistry Department, Science College, King Saud University; 3Anatomy Department, Faculty of Medicine, Cairo University, Cairo, EgyptAbstract: Nanotechnology has b...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Abir O El-Sadik, Afaf El-Ansary, Sherif M Sabry
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/20a0eba3ebf543fca4ca7999966157f6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:20a0eba3ebf543fca4ca7999966157f6
record_format	dspace
spelling	oai:doaj.org-article:20a0eba3ebf543fca4ca7999966157f62021-12-02T01:37:47ZNanoparticle-labeled stem cells: a novel therapeutic vehicle1179-1438https://doaj.org/article/20a0eba3ebf543fca4ca7999966157f62010-03-01T00:00:00Zhttp://www.dovepress.com/nanoparticle-labeled-stem-cells-a-novel-therapeutic-vehicle-a4102https://doaj.org/toc/1179-1438Abir O El-Sadik1, Afaf El-Ansary2, Sherif M Sabry31Stem Cell Unit, Anatomy Department, College of Medicine, Health Science Colleges; 2Biochemistry Department, Science College, King Saud University; 3Anatomy Department, Faculty of Medicine, Cairo University, Cairo, EgyptAbstract: Nanotechnology has been described as a general purpose technology. It has already generated a range of inventions and innovations. Development of nanotechnology will provide clinical medicine with a range of new diagnostic and therapeutic opportunities such as medical imaging, medical diagnosis, drug delivery, and cancer detection and management. Nanoparticles such as manganese, polystyrene, silica, titanium oxide, gold, silver, carbon, quantum dots, and iron oxide have received enormous attention in the creation of new types of analytical tools for biotechnology and life sciences. Labeling of stem cells with nanoparticles overcame the problems in homing and fixing stem cells to their desired site and guiding extension of stem cells to specific directions. Although the biologic effects of some nanoparticles have already been assessed, information on toxicity and possible mechanisms of various particle types remains inadequate. The aim of this review is to give an overview of the mechanisms of internalization and distribution of nanoparticles inside stem cells, as well as the influence of different types of nanoparticles on stem cell viability, proliferation, differentiation, and cytotoxicity, and to assess the role of nanoparticles in tracking the fate of stem cells used in tissue regeneration.Keywords: nanoparticles, stem cells, uptake, differentiation, cytotoxicity, tracking Abir O El-SadikAfaf El-AnsarySherif M SabryDove Medical PressarticleTherapeutics. PharmacologyRM1-950ENClinical Pharmacology: Advances and Applications, Vol 2010, Iss default, Pp 9-16 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Therapeutics. Pharmacology RM1-950
spellingShingle	Therapeutics. Pharmacology RM1-950 Abir O El-Sadik Afaf El-Ansary Sherif M Sabry Nanoparticle-labeled stem cells: a novel therapeutic vehicle
description	Abir O El-Sadik1, Afaf El-Ansary2, Sherif M Sabry31Stem Cell Unit, Anatomy Department, College of Medicine, Health Science Colleges; 2Biochemistry Department, Science College, King Saud University; 3Anatomy Department, Faculty of Medicine, Cairo University, Cairo, EgyptAbstract: Nanotechnology has been described as a general purpose technology. It has already generated a range of inventions and innovations. Development of nanotechnology will provide clinical medicine with a range of new diagnostic and therapeutic opportunities such as medical imaging, medical diagnosis, drug delivery, and cancer detection and management. Nanoparticles such as manganese, polystyrene, silica, titanium oxide, gold, silver, carbon, quantum dots, and iron oxide have received enormous attention in the creation of new types of analytical tools for biotechnology and life sciences. Labeling of stem cells with nanoparticles overcame the problems in homing and fixing stem cells to their desired site and guiding extension of stem cells to specific directions. Although the biologic effects of some nanoparticles have already been assessed, information on toxicity and possible mechanisms of various particle types remains inadequate. The aim of this review is to give an overview of the mechanisms of internalization and distribution of nanoparticles inside stem cells, as well as the influence of different types of nanoparticles on stem cell viability, proliferation, differentiation, and cytotoxicity, and to assess the role of nanoparticles in tracking the fate of stem cells used in tissue regeneration.Keywords: nanoparticles, stem cells, uptake, differentiation, cytotoxicity, tracking
format	article
author	Abir O El-Sadik Afaf El-Ansary Sherif M Sabry
author_facet	Abir O El-Sadik Afaf El-Ansary Sherif M Sabry
author_sort	Abir O El-Sadik
title	Nanoparticle-labeled stem cells: a novel therapeutic vehicle
title_short	Nanoparticle-labeled stem cells: a novel therapeutic vehicle
title_full	Nanoparticle-labeled stem cells: a novel therapeutic vehicle
title_fullStr	Nanoparticle-labeled stem cells: a novel therapeutic vehicle
title_full_unstemmed	Nanoparticle-labeled stem cells: a novel therapeutic vehicle
title_sort	nanoparticle-labeled stem cells: a novel therapeutic vehicle
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/20a0eba3ebf543fca4ca7999966157f6
work_keys_str_mv	AT abiroelsadik nanoparticlelabeledstemcellsanoveltherapeuticvehicle AT afafelansary nanoparticlelabeledstemcellsanoveltherapeuticvehicle AT sherifmsabry nanoparticlelabeledstemcellsanoveltherapeuticvehicle
_version_	1718402944419758080

Nanoparticle-labeled stem cells: a novel therapeutic vehicle

Ejemplares similares