In vivo Dynamic Phase-Contrast X-ray Imaging using a Compact Light Source
Abstract We describe the first dynamic and the first in vivo X-ray imaging studies successfully performed at a laser-undulator-based compact synchrotron light source. The X-ray properties of this source enable time-sequence propagation-based X-ray phase-contrast imaging. We focus here on non-invasiv...
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Nature Portfolio
2018
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oai:doaj.org-article:20a218d45c0c407f887be63254e6c1772021-12-02T11:40:26ZIn vivo Dynamic Phase-Contrast X-ray Imaging using a Compact Light Source10.1038/s41598-018-24763-82045-2322https://doaj.org/article/20a218d45c0c407f887be63254e6c1772018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-24763-8https://doaj.org/toc/2045-2322Abstract We describe the first dynamic and the first in vivo X-ray imaging studies successfully performed at a laser-undulator-based compact synchrotron light source. The X-ray properties of this source enable time-sequence propagation-based X-ray phase-contrast imaging. We focus here on non-invasive imaging for respiratory treatment development and physiological understanding. In small animals, we capture the regional delivery of respiratory treatment, and two measures of respiratory health that can reveal the effectiveness of a treatment; lung motion and mucociliary clearance. The results demonstrate the ability of this set-up to perform laboratory-based dynamic imaging, specifically in small animal models, and with the possibility of longitudinal studies.Regine GradlMartin DierolfBenedikt GüntherLorenz HehnWinfried MöllerDavid KutschkeLin YangMartin DonnelleyRhiannon MurrieAlexander ErlTobias StoegerBernhard GleichKlaus AchterholdOtmar SchmidFranz PfeifferKaye Susannah MorganNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Regine Gradl Martin Dierolf Benedikt Günther Lorenz Hehn Winfried Möller David Kutschke Lin Yang Martin Donnelley Rhiannon Murrie Alexander Erl Tobias Stoeger Bernhard Gleich Klaus Achterhold Otmar Schmid Franz Pfeiffer Kaye Susannah Morgan In vivo Dynamic Phase-Contrast X-ray Imaging using a Compact Light Source |
| description |
Abstract We describe the first dynamic and the first in vivo X-ray imaging studies successfully performed at a laser-undulator-based compact synchrotron light source. The X-ray properties of this source enable time-sequence propagation-based X-ray phase-contrast imaging. We focus here on non-invasive imaging for respiratory treatment development and physiological understanding. In small animals, we capture the regional delivery of respiratory treatment, and two measures of respiratory health that can reveal the effectiveness of a treatment; lung motion and mucociliary clearance. The results demonstrate the ability of this set-up to perform laboratory-based dynamic imaging, specifically in small animal models, and with the possibility of longitudinal studies. |
| format |
article |
| author |
Regine Gradl Martin Dierolf Benedikt Günther Lorenz Hehn Winfried Möller David Kutschke Lin Yang Martin Donnelley Rhiannon Murrie Alexander Erl Tobias Stoeger Bernhard Gleich Klaus Achterhold Otmar Schmid Franz Pfeiffer Kaye Susannah Morgan |
| author_facet |
Regine Gradl Martin Dierolf Benedikt Günther Lorenz Hehn Winfried Möller David Kutschke Lin Yang Martin Donnelley Rhiannon Murrie Alexander Erl Tobias Stoeger Bernhard Gleich Klaus Achterhold Otmar Schmid Franz Pfeiffer Kaye Susannah Morgan |
| author_sort |
Regine Gradl |
| title |
In vivo Dynamic Phase-Contrast X-ray Imaging using a Compact Light Source |
| title_short |
In vivo Dynamic Phase-Contrast X-ray Imaging using a Compact Light Source |
| title_full |
In vivo Dynamic Phase-Contrast X-ray Imaging using a Compact Light Source |
| title_fullStr |
In vivo Dynamic Phase-Contrast X-ray Imaging using a Compact Light Source |
| title_full_unstemmed |
In vivo Dynamic Phase-Contrast X-ray Imaging using a Compact Light Source |
| title_sort |
in vivo dynamic phase-contrast x-ray imaging using a compact light source |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/20a218d45c0c407f887be63254e6c177 |
| work_keys_str_mv |
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