Fighting Staphylococcus epidermidis Biofilm-Associated Infections: Can Iron Be the Key to Success?

Staphylococcus epidermidis is one of the most important commensal microorganisms of human skin and mucosae. However, this bacterial species is also the cause of severe infections in immunocompromised patients, specially associated with the utilization of indwelling medical devices, that often serve...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fernando Oliveira, Holger Rohde, Manuel Vilanova, Nuno Cerca
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	iron acquisition systems regulation of iron acquisition Siderophores S. epidermidis biofilms role of iron in infection Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/20a7da0e402549c38b10f5cffa46efe0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:20a7da0e402549c38b10f5cffa46efe0
record_format	dspace
spelling	oai:doaj.org-article:20a7da0e402549c38b10f5cffa46efe02021-12-01T19:48:21ZFighting Staphylococcus epidermidis Biofilm-Associated Infections: Can Iron Be the Key to Success?2235-298810.3389/fcimb.2021.798563https://doaj.org/article/20a7da0e402549c38b10f5cffa46efe02021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcimb.2021.798563/fullhttps://doaj.org/toc/2235-2988Staphylococcus epidermidis is one of the most important commensal microorganisms of human skin and mucosae. However, this bacterial species is also the cause of severe infections in immunocompromised patients, specially associated with the utilization of indwelling medical devices, that often serve as a scaffold for biofilm formation. S. epidermidis strains are often multidrug resistant and its association with biofilm formation makes these infections hard to treat. Their remarkable ability to form biofilms is widely regarded as its major pathogenic determinant. Although a significant amount of knowledge on its biofilm formation mechanisms has been achieved, we still do not understand how the species survives when exposed to the host harsh environment during invasion. A previous RNA-seq study highlighted that iron-metabolism associated genes were the most up-regulated bacterial genes upon contact with human blood, which suggested that iron acquisition plays an important role in S. epidermidis biofilm development and escape from the host innate immune system. In this perspective article, we review the available literature on the role of iron metabolism on S. epidermidis pathogenesis and propose that exploiting its dependence on iron could be pursued as a viable therapeutic alternative.Fernando OliveiraHolger RohdeManuel VilanovaManuel VilanovaManuel VilanovaNuno CercaFrontiers Media S.A.articleiron acquisition systemsregulation of iron acquisitionSiderophoresS. epidermidis biofilmsrole of iron in infectionMicrobiologyQR1-502ENFrontiers in Cellular and Infection Microbiology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	iron acquisition systems regulation of iron acquisition Siderophores S. epidermidis biofilms role of iron in infection Microbiology QR1-502
spellingShingle	iron acquisition systems regulation of iron acquisition Siderophores S. epidermidis biofilms role of iron in infection Microbiology QR1-502 Fernando Oliveira Holger Rohde Manuel Vilanova Manuel Vilanova Manuel Vilanova Nuno Cerca Fighting Staphylococcus epidermidis Biofilm-Associated Infections: Can Iron Be the Key to Success?
description	Staphylococcus epidermidis is one of the most important commensal microorganisms of human skin and mucosae. However, this bacterial species is also the cause of severe infections in immunocompromised patients, specially associated with the utilization of indwelling medical devices, that often serve as a scaffold for biofilm formation. S. epidermidis strains are often multidrug resistant and its association with biofilm formation makes these infections hard to treat. Their remarkable ability to form biofilms is widely regarded as its major pathogenic determinant. Although a significant amount of knowledge on its biofilm formation mechanisms has been achieved, we still do not understand how the species survives when exposed to the host harsh environment during invasion. A previous RNA-seq study highlighted that iron-metabolism associated genes were the most up-regulated bacterial genes upon contact with human blood, which suggested that iron acquisition plays an important role in S. epidermidis biofilm development and escape from the host innate immune system. In this perspective article, we review the available literature on the role of iron metabolism on S. epidermidis pathogenesis and propose that exploiting its dependence on iron could be pursued as a viable therapeutic alternative.
format	article
author	Fernando Oliveira Holger Rohde Manuel Vilanova Manuel Vilanova Manuel Vilanova Nuno Cerca
author_facet	Fernando Oliveira Holger Rohde Manuel Vilanova Manuel Vilanova Manuel Vilanova Nuno Cerca
author_sort	Fernando Oliveira
title	Fighting Staphylococcus epidermidis Biofilm-Associated Infections: Can Iron Be the Key to Success?
title_short	Fighting Staphylococcus epidermidis Biofilm-Associated Infections: Can Iron Be the Key to Success?
title_full	Fighting Staphylococcus epidermidis Biofilm-Associated Infections: Can Iron Be the Key to Success?
title_fullStr	Fighting Staphylococcus epidermidis Biofilm-Associated Infections: Can Iron Be the Key to Success?
title_full_unstemmed	Fighting Staphylococcus epidermidis Biofilm-Associated Infections: Can Iron Be the Key to Success?
title_sort	fighting staphylococcus epidermidis biofilm-associated infections: can iron be the key to success?
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/20a7da0e402549c38b10f5cffa46efe0
work_keys_str_mv	AT fernandooliveira fightingstaphylococcusepidermidisbiofilmassociatedinfectionscanironbethekeytosuccess AT holgerrohde fightingstaphylococcusepidermidisbiofilmassociatedinfectionscanironbethekeytosuccess AT manuelvilanova fightingstaphylococcusepidermidisbiofilmassociatedinfectionscanironbethekeytosuccess AT manuelvilanova fightingstaphylococcusepidermidisbiofilmassociatedinfectionscanironbethekeytosuccess AT manuelvilanova fightingstaphylococcusepidermidisbiofilmassociatedinfectionscanironbethekeytosuccess AT nunocerca fightingstaphylococcusepidermidisbiofilmassociatedinfectionscanironbethekeytosuccess
_version_	1718404560823779328

Fighting Staphylococcus epidermidis Biofilm-Associated Infections: Can Iron Be the Key to Success?

Ejemplares similares