Degradation of phenylethanoid glycosides in Osmanthus fragrans Lour. flowers and its effect on anti-hypoxia activity

Abstract This study was aimed at investigating the chemical stability (the thermal, light and pH stability) of phenylethanoid glycosides (PhGs) in Osmanthus fragrans Lour. flowers, identifying the degradation products of acteoside and salidroside (major PhGs in O. fragrans flowers) by UPLC–QTOF–MS a...

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Autores principales:	Fei Zhou, Yajing Zhao, Maiquan Li, Tao Xu, Liuquan Zhang, Baiyi Lu, Xiaodan Wu, Zhiwei Ge
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/20a816ef8cfd4c7ba385c3ad2973eda2
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spelling	oai:doaj.org-article:20a816ef8cfd4c7ba385c3ad2973eda22021-12-02T15:06:25ZDegradation of phenylethanoid glycosides in Osmanthus fragrans Lour. flowers and its effect on anti-hypoxia activity10.1038/s41598-017-10411-02045-2322https://doaj.org/article/20a816ef8cfd4c7ba385c3ad2973eda22017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-10411-0https://doaj.org/toc/2045-2322Abstract This study was aimed at investigating the chemical stability (the thermal, light and pH stability) of phenylethanoid glycosides (PhGs) in Osmanthus fragrans Lour. flowers, identifying the degradation products of acteoside and salidroside (major PhGs in O. fragrans flowers) by UPLC–QTOF–MS and studying the anti-hypoxia activity of PhGs after degradation. The degradation of PhGs followed first-order reaction kinetics, and the rate constant of acteoside (4.3 to 203.4 × 10−3 day−1) was higher than that of salidroside (3.9 to 33.3 × 10−3 day−1) in O. fragrans flowers. Salidroside was mainly hydrolyzed to tyrosol during storage, and the degradation products of acteoside were verbasoside, caffeic acid, isoacteoside, etc. In a model of cobalt chloride (CoCl2)-induced hypoxia in PC12 cells, the anti-hypoxia ability of PhGs decreased after degradation, which resulted from the reduction of PhGs contents. Particularly, caffeic acid exhibited stronger anti-hypoxia ability than acteoside and could slightly increase the anti-hypoxia ability of degraded acteoside. The results revealed that high temperature, high pH and light exposure caused PhGs degradation, and thus the anti-hypoxia ability of PhGs reduced.Fei ZhouYajing ZhaoMaiquan LiTao XuLiuquan ZhangBaiyi LuXiaodan WuZhiwei GeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fei Zhou Yajing Zhao Maiquan Li Tao Xu Liuquan Zhang Baiyi Lu Xiaodan Wu Zhiwei Ge Degradation of phenylethanoid glycosides in Osmanthus fragrans Lour. flowers and its effect on anti-hypoxia activity
description	Abstract This study was aimed at investigating the chemical stability (the thermal, light and pH stability) of phenylethanoid glycosides (PhGs) in Osmanthus fragrans Lour. flowers, identifying the degradation products of acteoside and salidroside (major PhGs in O. fragrans flowers) by UPLC–QTOF–MS and studying the anti-hypoxia activity of PhGs after degradation. The degradation of PhGs followed first-order reaction kinetics, and the rate constant of acteoside (4.3 to 203.4 × 10−3 day−1) was higher than that of salidroside (3.9 to 33.3 × 10−3 day−1) in O. fragrans flowers. Salidroside was mainly hydrolyzed to tyrosol during storage, and the degradation products of acteoside were verbasoside, caffeic acid, isoacteoside, etc. In a model of cobalt chloride (CoCl2)-induced hypoxia in PC12 cells, the anti-hypoxia ability of PhGs decreased after degradation, which resulted from the reduction of PhGs contents. Particularly, caffeic acid exhibited stronger anti-hypoxia ability than acteoside and could slightly increase the anti-hypoxia ability of degraded acteoside. The results revealed that high temperature, high pH and light exposure caused PhGs degradation, and thus the anti-hypoxia ability of PhGs reduced.
format	article
author	Fei Zhou Yajing Zhao Maiquan Li Tao Xu Liuquan Zhang Baiyi Lu Xiaodan Wu Zhiwei Ge
author_facet	Fei Zhou Yajing Zhao Maiquan Li Tao Xu Liuquan Zhang Baiyi Lu Xiaodan Wu Zhiwei Ge
author_sort	Fei Zhou
title	Degradation of phenylethanoid glycosides in Osmanthus fragrans Lour. flowers and its effect on anti-hypoxia activity
title_short	Degradation of phenylethanoid glycosides in Osmanthus fragrans Lour. flowers and its effect on anti-hypoxia activity
title_full	Degradation of phenylethanoid glycosides in Osmanthus fragrans Lour. flowers and its effect on anti-hypoxia activity
title_fullStr	Degradation of phenylethanoid glycosides in Osmanthus fragrans Lour. flowers and its effect on anti-hypoxia activity
title_full_unstemmed	Degradation of phenylethanoid glycosides in Osmanthus fragrans Lour. flowers and its effect on anti-hypoxia activity
title_sort	degradation of phenylethanoid glycosides in osmanthus fragrans lour. flowers and its effect on anti-hypoxia activity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/20a816ef8cfd4c7ba385c3ad2973eda2
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Degradation of phenylethanoid glycosides in Osmanthus fragrans Lour. flowers and its effect on anti-hypoxia activity

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