A Concise Review on the Role of CircPVT1 in Tumorigenesis, Drug Sensitivity, and Cancer Prognosis

CircPVT1 (hsa_circ_0001821) is a cancer-related circular RNA (circRNA) that originated from a genomic locus on chromosome 8q24. This locus has been previously found to encode the oncogenic long non-coding RNA PVT1. Expression of this circRNA has been found to be upregulated in diverse neoplastic con...

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Autores principales:	Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Mohammad Taheri, Elena Jamali
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	circRNA circPVT1 cancer expression biomarker Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/20a90267ba1847acbd215759c2c79ffd
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spelling	oai:doaj.org-article:20a90267ba1847acbd215759c2c79ffd2021-11-04T05:46:53ZA Concise Review on the Role of CircPVT1 in Tumorigenesis, Drug Sensitivity, and Cancer Prognosis2234-943X10.3389/fonc.2021.762960https://doaj.org/article/20a90267ba1847acbd215759c2c79ffd2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.762960/fullhttps://doaj.org/toc/2234-943XCircPVT1 (hsa_circ_0001821) is a cancer-related circular RNA (circRNA) that originated from a genomic locus on chromosome 8q24. This locus has been previously found to encode the oncogenic long non-coding RNA PVT1. Expression of this circRNA has been found to be upregulated in diverse neoplastic conditions. CircPVT1 acts as a sponge for miR-125a, miR-125b, miR-124-3p, miR-30a-5p, miR-205-5p, miR‐423‐5p, miR‐526b, miR-137, miR-145-5p, miR-497, miR-30d/e, miR-455-5p, miR-29a-3p, miR-204-5p, miR-149, miR-106a-5p, miR-377, miR-3666, miR-203, and miR-199a-5p. Moreover, it can regulate the activities of PI3K/AKT, Wnt5a/Ror2, E2F2, and HIF-1α. Upregulation of circPVT1 has been correlated with decreased survival of patients with different cancer types. In the current review, we explain the oncogenic impact of circPVT1 in different tissues based on evidence from in vitro, in vivo, and clinical investigations.Soudeh Ghafouri-FardTayyebeh KhoshbakhtMohammad TaheriMohammad TaheriElena JamaliElena JamaliFrontiers Media S.A.articlecircRNAcircPVT1cancerexpressionbiomarkerNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	circRNA circPVT1 cancer expression biomarker Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	circRNA circPVT1 cancer expression biomarker Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Soudeh Ghafouri-Fard Tayyebeh Khoshbakht Mohammad Taheri Mohammad Taheri Elena Jamali Elena Jamali A Concise Review on the Role of CircPVT1 in Tumorigenesis, Drug Sensitivity, and Cancer Prognosis
description	CircPVT1 (hsa_circ_0001821) is a cancer-related circular RNA (circRNA) that originated from a genomic locus on chromosome 8q24. This locus has been previously found to encode the oncogenic long non-coding RNA PVT1. Expression of this circRNA has been found to be upregulated in diverse neoplastic conditions. CircPVT1 acts as a sponge for miR-125a, miR-125b, miR-124-3p, miR-30a-5p, miR-205-5p, miR‐423‐5p, miR‐526b, miR-137, miR-145-5p, miR-497, miR-30d/e, miR-455-5p, miR-29a-3p, miR-204-5p, miR-149, miR-106a-5p, miR-377, miR-3666, miR-203, and miR-199a-5p. Moreover, it can regulate the activities of PI3K/AKT, Wnt5a/Ror2, E2F2, and HIF-1α. Upregulation of circPVT1 has been correlated with decreased survival of patients with different cancer types. In the current review, we explain the oncogenic impact of circPVT1 in different tissues based on evidence from in vitro, in vivo, and clinical investigations.
format	article
author	Soudeh Ghafouri-Fard Tayyebeh Khoshbakht Mohammad Taheri Mohammad Taheri Elena Jamali Elena Jamali
author_facet	Soudeh Ghafouri-Fard Tayyebeh Khoshbakht Mohammad Taheri Mohammad Taheri Elena Jamali Elena Jamali
author_sort	Soudeh Ghafouri-Fard
title	A Concise Review on the Role of CircPVT1 in Tumorigenesis, Drug Sensitivity, and Cancer Prognosis
title_short	A Concise Review on the Role of CircPVT1 in Tumorigenesis, Drug Sensitivity, and Cancer Prognosis
title_full	A Concise Review on the Role of CircPVT1 in Tumorigenesis, Drug Sensitivity, and Cancer Prognosis
title_fullStr	A Concise Review on the Role of CircPVT1 in Tumorigenesis, Drug Sensitivity, and Cancer Prognosis
title_full_unstemmed	A Concise Review on the Role of CircPVT1 in Tumorigenesis, Drug Sensitivity, and Cancer Prognosis
title_sort	concise review on the role of circpvt1 in tumorigenesis, drug sensitivity, and cancer prognosis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/20a90267ba1847acbd215759c2c79ffd
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A Concise Review on the Role of CircPVT1 in Tumorigenesis, Drug Sensitivity, and Cancer Prognosis

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