Integrative Radiogenomics Approach for Risk Assessment of Postoperative and Adjuvant Chemotherapy Benefits for Gastric Cancer Patients

Gastric cancer (GC) is a typical heterogeneous malignant tumor, whose insensitivity to chemotherapy is a common cause of tumor recurrence and metastasis. There is no doubt regarding the effectiveness of adjuvant chemotherapy (ACT) for GC, but the population for whom it is indicated and the selection...

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Autores principales:	Yin Jin, Yilun Xu, Yanyan Li, Renpin Chen, Weiyang Cai
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	radiogenomics adjuvant chemotherapy benefit postoperative gastric cancer nomogram survival prediction Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/20aa359a29484ab28165cbedfe051ff0
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spelling	oai:doaj.org-article:20aa359a29484ab28165cbedfe051ff02021-11-05T09:12:40ZIntegrative Radiogenomics Approach for Risk Assessment of Postoperative and Adjuvant Chemotherapy Benefits for Gastric Cancer Patients2234-943X10.3389/fonc.2021.755271https://doaj.org/article/20aa359a29484ab28165cbedfe051ff02021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.755271/fullhttps://doaj.org/toc/2234-943XGastric cancer (GC) is a typical heterogeneous malignant tumor, whose insensitivity to chemotherapy is a common cause of tumor recurrence and metastasis. There is no doubt regarding the effectiveness of adjuvant chemotherapy (ACT) for GC, but the population for whom it is indicated and the selection of specific options remain the focus of present research. The conventional pathological TNM prediction focuses on cancer cells to predict prognosis, while they do not provide sufficient prediction. Enhanced computed tomography (CT) scanning is a validated tool that assesses the involvement of careful identification of the tumor, lymph node involvement, and metastatic spread. Using the radiomics approach, we selected the least absolute shrinkage and selection operator (LASSO) Cox regression model to build a radiomics signature for predicting the overall survival (OS) and disease-free survival (DFS) of patients with complete postoperative gastric cancer and further identifying candidate benefits from ACT. The radiomics trait-associated genes captured clinically relevant molecular pathways and potential chemotherapeutic drug metabolism mechanisms. Our results of precise surrogates using radiogenomics can lead to additional benefit from adjuvant chemotherapy and then survival prediction in postoperative GC patients.Yin JinYilun XuYanyan LiRenpin ChenWeiyang CaiFrontiers Media S.A.articleradiogenomicsadjuvant chemotherapy benefitpostoperative gastric cancernomogramsurvival predictionNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	radiogenomics adjuvant chemotherapy benefit postoperative gastric cancer nomogram survival prediction Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	radiogenomics adjuvant chemotherapy benefit postoperative gastric cancer nomogram survival prediction Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Yin Jin Yilun Xu Yanyan Li Renpin Chen Weiyang Cai Integrative Radiogenomics Approach for Risk Assessment of Postoperative and Adjuvant Chemotherapy Benefits for Gastric Cancer Patients
description	Gastric cancer (GC) is a typical heterogeneous malignant tumor, whose insensitivity to chemotherapy is a common cause of tumor recurrence and metastasis. There is no doubt regarding the effectiveness of adjuvant chemotherapy (ACT) for GC, but the population for whom it is indicated and the selection of specific options remain the focus of present research. The conventional pathological TNM prediction focuses on cancer cells to predict prognosis, while they do not provide sufficient prediction. Enhanced computed tomography (CT) scanning is a validated tool that assesses the involvement of careful identification of the tumor, lymph node involvement, and metastatic spread. Using the radiomics approach, we selected the least absolute shrinkage and selection operator (LASSO) Cox regression model to build a radiomics signature for predicting the overall survival (OS) and disease-free survival (DFS) of patients with complete postoperative gastric cancer and further identifying candidate benefits from ACT. The radiomics trait-associated genes captured clinically relevant molecular pathways and potential chemotherapeutic drug metabolism mechanisms. Our results of precise surrogates using radiogenomics can lead to additional benefit from adjuvant chemotherapy and then survival prediction in postoperative GC patients.
format	article
author	Yin Jin Yilun Xu Yanyan Li Renpin Chen Weiyang Cai
author_facet	Yin Jin Yilun Xu Yanyan Li Renpin Chen Weiyang Cai
author_sort	Yin Jin
title	Integrative Radiogenomics Approach for Risk Assessment of Postoperative and Adjuvant Chemotherapy Benefits for Gastric Cancer Patients
title_short	Integrative Radiogenomics Approach for Risk Assessment of Postoperative and Adjuvant Chemotherapy Benefits for Gastric Cancer Patients
title_full	Integrative Radiogenomics Approach for Risk Assessment of Postoperative and Adjuvant Chemotherapy Benefits for Gastric Cancer Patients
title_fullStr	Integrative Radiogenomics Approach for Risk Assessment of Postoperative and Adjuvant Chemotherapy Benefits for Gastric Cancer Patients
title_full_unstemmed	Integrative Radiogenomics Approach for Risk Assessment of Postoperative and Adjuvant Chemotherapy Benefits for Gastric Cancer Patients
title_sort	integrative radiogenomics approach for risk assessment of postoperative and adjuvant chemotherapy benefits for gastric cancer patients
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/20aa359a29484ab28165cbedfe051ff0
work_keys_str_mv	AT yinjin integrativeradiogenomicsapproachforriskassessmentofpostoperativeandadjuvantchemotherapybenefitsforgastriccancerpatients AT yilunxu integrativeradiogenomicsapproachforriskassessmentofpostoperativeandadjuvantchemotherapybenefitsforgastriccancerpatients AT yanyanli integrativeradiogenomicsapproachforriskassessmentofpostoperativeandadjuvantchemotherapybenefitsforgastriccancerpatients AT renpinchen integrativeradiogenomicsapproachforriskassessmentofpostoperativeandadjuvantchemotherapybenefitsforgastriccancerpatients AT weiyangcai integrativeradiogenomicsapproachforriskassessmentofpostoperativeandadjuvantchemotherapybenefitsforgastriccancerpatients
_version_	1718444395907252224

Integrative Radiogenomics Approach for Risk Assessment of Postoperative and Adjuvant Chemotherapy Benefits for Gastric Cancer Patients

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