Comparison of oral microbiome profiles in 18-month-old infants and their parents

Abstract The onset and progress of dental caries and periodontal disease is associated with the oral microbiome. Therefore, it is important to understand the factors that influence oral microbiome formation. One of the factors that influence oral microbiome formation is the transmission of oral bact...

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Autores principales:	Ryutaro Jo, Kazuma Yama, Yuto Aita, Kota Tsutsumi, Chikako Ishihara, Masato Maruyama, Kaori Takeda, Eiji Nishinaga, Ken-ichiro Shibasaki, Seiji Morishima
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/20addc3361f341c397a720e814e19b80
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spelling	oai:doaj.org-article:20addc3361f341c397a720e814e19b802021-12-02T14:01:35ZComparison of oral microbiome profiles in 18-month-old infants and their parents10.1038/s41598-020-78295-12045-2322https://doaj.org/article/20addc3361f341c397a720e814e19b802021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78295-1https://doaj.org/toc/2045-2322Abstract The onset and progress of dental caries and periodontal disease is associated with the oral microbiome. Therefore, it is important to understand the factors that influence oral microbiome formation. One of the factors that influence oral microbiome formation is the transmission of oral bacteria from parents. However, it remains unclear when the transmission begins, and the difference in contributions of father and mother. Here, we focused on the oral microbiome of 18-month-old infants, at which age deciduous dentition is formed and the oral microbiome is likely to become stable, with that of their parents. We collected saliva from forty 18-month-old infants and their parents and compared the diversity and composition of the microbiome using next-generation sequencing of 16S rRNA genes. The results showed that microbial diversity in infants was significantly lower than that in parents and composition of microbiome were significantly different between infants and parents. Meanwhile, the microbiome of the infants was more similar to that of their mothers than unrelated adults. The bacteria highly shared between infants and parents included not only commensal bacteria but also disease related bacteria. These results suggested that the oral microbiome of the parents influences that of their children aged < 18 months.Ryutaro JoKazuma YamaYuto AitaKota TsutsumiChikako IshiharaMasato MaruyamaKaori TakedaEiji NishinagaKen-ichiro ShibasakiSeiji MorishimaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ryutaro Jo Kazuma Yama Yuto Aita Kota Tsutsumi Chikako Ishihara Masato Maruyama Kaori Takeda Eiji Nishinaga Ken-ichiro Shibasaki Seiji Morishima Comparison of oral microbiome profiles in 18-month-old infants and their parents
description	Abstract The onset and progress of dental caries and periodontal disease is associated with the oral microbiome. Therefore, it is important to understand the factors that influence oral microbiome formation. One of the factors that influence oral microbiome formation is the transmission of oral bacteria from parents. However, it remains unclear when the transmission begins, and the difference in contributions of father and mother. Here, we focused on the oral microbiome of 18-month-old infants, at which age deciduous dentition is formed and the oral microbiome is likely to become stable, with that of their parents. We collected saliva from forty 18-month-old infants and their parents and compared the diversity and composition of the microbiome using next-generation sequencing of 16S rRNA genes. The results showed that microbial diversity in infants was significantly lower than that in parents and composition of microbiome were significantly different between infants and parents. Meanwhile, the microbiome of the infants was more similar to that of their mothers than unrelated adults. The bacteria highly shared between infants and parents included not only commensal bacteria but also disease related bacteria. These results suggested that the oral microbiome of the parents influences that of their children aged < 18 months.
format	article
author	Ryutaro Jo Kazuma Yama Yuto Aita Kota Tsutsumi Chikako Ishihara Masato Maruyama Kaori Takeda Eiji Nishinaga Ken-ichiro Shibasaki Seiji Morishima
author_facet	Ryutaro Jo Kazuma Yama Yuto Aita Kota Tsutsumi Chikako Ishihara Masato Maruyama Kaori Takeda Eiji Nishinaga Ken-ichiro Shibasaki Seiji Morishima
author_sort	Ryutaro Jo
title	Comparison of oral microbiome profiles in 18-month-old infants and their parents
title_short	Comparison of oral microbiome profiles in 18-month-old infants and their parents
title_full	Comparison of oral microbiome profiles in 18-month-old infants and their parents
title_fullStr	Comparison of oral microbiome profiles in 18-month-old infants and their parents
title_full_unstemmed	Comparison of oral microbiome profiles in 18-month-old infants and their parents
title_sort	comparison of oral microbiome profiles in 18-month-old infants and their parents
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/20addc3361f341c397a720e814e19b80
work_keys_str_mv	AT ryutarojo comparisonoforalmicrobiomeprofilesin18montholdinfantsandtheirparents AT kazumayama comparisonoforalmicrobiomeprofilesin18montholdinfantsandtheirparents AT yutoaita comparisonoforalmicrobiomeprofilesin18montholdinfantsandtheirparents AT kotatsutsumi comparisonoforalmicrobiomeprofilesin18montholdinfantsandtheirparents AT chikakoishihara comparisonoforalmicrobiomeprofilesin18montholdinfantsandtheirparents AT masatomaruyama comparisonoforalmicrobiomeprofilesin18montholdinfantsandtheirparents AT kaoritakeda comparisonoforalmicrobiomeprofilesin18montholdinfantsandtheirparents AT eijinishinaga comparisonoforalmicrobiomeprofilesin18montholdinfantsandtheirparents AT kenichiroshibasaki comparisonoforalmicrobiomeprofilesin18montholdinfantsandtheirparents AT seijimorishima comparisonoforalmicrobiomeprofilesin18montholdinfantsandtheirparents
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Comparison of oral microbiome profiles in 18-month-old infants and their parents

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