miRNA-mediated TUSC3 deficiency enhances UPR and ERAD to promote metastatic potential of NSCLC

TUSC3 resides on chromosome 8p which is frequently deleted in advanced stage tumors. Here, the authors show that TUSC3 loss mediated by miR-224/-520c promotes NSCLC metastasis where it enhances ATF-6α-dependent UPR and HRD-1 dependent ERAD, which in turn suppress p53-NM23H1/2 tumor suppressor pathwa...

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Autores principales:	Young-Jun Jeon, Taewan Kim, Dongju Park, Gerard J. Nuovo, Siyeon Rhee, Pooja Joshi, Bum-Kyu Lee, Johan Jeong, Sung-suk Suh, Jeff E. Grotzke, Sung-Hak Kim, Jieun Song, Hosung Sim, Yonghwan Kim, Yong Peng, Youngtae Jeong, Michela Garofalo, Nicola Zanesi, Jonghwan Kim, Guang Liang, Ichiro Nakano, Peter Cresswell, Patrick Nana-Sinkam, Ri Cui, Carlo M. Croce
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/20aea16a00a84e518d6ba422033dbee0
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spelling	oai:doaj.org-article:20aea16a00a84e518d6ba422033dbee02021-12-02T17:33:06ZmiRNA-mediated TUSC3 deficiency enhances UPR and ERAD to promote metastatic potential of NSCLC10.1038/s41467-018-07561-82041-1723https://doaj.org/article/20aea16a00a84e518d6ba422033dbee02018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07561-8https://doaj.org/toc/2041-1723TUSC3 resides on chromosome 8p which is frequently deleted in advanced stage tumors. Here, the authors show that TUSC3 loss mediated by miR-224/-520c promotes NSCLC metastasis where it enhances ATF-6α-dependent UPR and HRD-1 dependent ERAD, which in turn suppress p53-NM23H1/2 tumor suppressor pathway.Young-Jun JeonTaewan KimDongju ParkGerard J. NuovoSiyeon RheePooja JoshiBum-Kyu LeeJohan JeongSung-suk SuhJeff E. GrotzkeSung-Hak KimJieun SongHosung SimYonghwan KimYong PengYoungtae JeongMichela GarofaloNicola ZanesiJonghwan KimGuang LiangIchiro NakanoPeter CresswellPatrick Nana-SinkamRi CuiCarlo M. CroceNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Young-Jun Jeon Taewan Kim Dongju Park Gerard J. Nuovo Siyeon Rhee Pooja Joshi Bum-Kyu Lee Johan Jeong Sung-suk Suh Jeff E. Grotzke Sung-Hak Kim Jieun Song Hosung Sim Yonghwan Kim Yong Peng Youngtae Jeong Michela Garofalo Nicola Zanesi Jonghwan Kim Guang Liang Ichiro Nakano Peter Cresswell Patrick Nana-Sinkam Ri Cui Carlo M. Croce miRNA-mediated TUSC3 deficiency enhances UPR and ERAD to promote metastatic potential of NSCLC
description	TUSC3 resides on chromosome 8p which is frequently deleted in advanced stage tumors. Here, the authors show that TUSC3 loss mediated by miR-224/-520c promotes NSCLC metastasis where it enhances ATF-6α-dependent UPR and HRD-1 dependent ERAD, which in turn suppress p53-NM23H1/2 tumor suppressor pathway.
format	article
author	Young-Jun Jeon Taewan Kim Dongju Park Gerard J. Nuovo Siyeon Rhee Pooja Joshi Bum-Kyu Lee Johan Jeong Sung-suk Suh Jeff E. Grotzke Sung-Hak Kim Jieun Song Hosung Sim Yonghwan Kim Yong Peng Youngtae Jeong Michela Garofalo Nicola Zanesi Jonghwan Kim Guang Liang Ichiro Nakano Peter Cresswell Patrick Nana-Sinkam Ri Cui Carlo M. Croce
author_facet	Young-Jun Jeon Taewan Kim Dongju Park Gerard J. Nuovo Siyeon Rhee Pooja Joshi Bum-Kyu Lee Johan Jeong Sung-suk Suh Jeff E. Grotzke Sung-Hak Kim Jieun Song Hosung Sim Yonghwan Kim Yong Peng Youngtae Jeong Michela Garofalo Nicola Zanesi Jonghwan Kim Guang Liang Ichiro Nakano Peter Cresswell Patrick Nana-Sinkam Ri Cui Carlo M. Croce
author_sort	Young-Jun Jeon
title	miRNA-mediated TUSC3 deficiency enhances UPR and ERAD to promote metastatic potential of NSCLC
title_short	miRNA-mediated TUSC3 deficiency enhances UPR and ERAD to promote metastatic potential of NSCLC
title_full	miRNA-mediated TUSC3 deficiency enhances UPR and ERAD to promote metastatic potential of NSCLC
title_fullStr	miRNA-mediated TUSC3 deficiency enhances UPR and ERAD to promote metastatic potential of NSCLC
title_full_unstemmed	miRNA-mediated TUSC3 deficiency enhances UPR and ERAD to promote metastatic potential of NSCLC
title_sort	mirna-mediated tusc3 deficiency enhances upr and erad to promote metastatic potential of nsclc
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/20aea16a00a84e518d6ba422033dbee0
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miRNA-mediated TUSC3 deficiency enhances UPR and ERAD to promote metastatic potential of NSCLC

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