The Importance of Mimicking Dermal-Epidermal Junction for Skin Tissue Engineering: A Review

There is a distinct boundary between the dermis and epidermis in the human skin called the basement membrane, a dense collagen network that creates undulations of the dermal–epidermal junction (DEJ). The DEJ plays multiple roles in skin homeostasis and function, namely, enhancing the adhesion and ph...

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Autores principales:	Mina Aleemardani, Michael Zivojin Trikić, Nicola Helen Green, Frederik Claeyssens
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	dermal-epidermal junction skin tissue engineering scaffolds physical factors topographical features Technology T Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/20aeb78a3e13471a93b9b4cfe1c9f973
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spelling	oai:doaj.org-article:20aeb78a3e13471a93b9b4cfe1c9f9732021-11-25T16:46:19ZThe Importance of Mimicking Dermal-Epidermal Junction for Skin Tissue Engineering: A Review10.3390/bioengineering81101482306-5354https://doaj.org/article/20aeb78a3e13471a93b9b4cfe1c9f9732021-10-01T00:00:00Zhttps://www.mdpi.com/2306-5354/8/11/148https://doaj.org/toc/2306-5354There is a distinct boundary between the dermis and epidermis in the human skin called the basement membrane, a dense collagen network that creates undulations of the dermal–epidermal junction (DEJ). The DEJ plays multiple roles in skin homeostasis and function, namely, enhancing the adhesion and physical interlock of the layers, creating niches for epidermal stem cells, regulating the cellular microenvironment, and providing a physical boundary layer between fibroblasts and keratinocytes. However, the primary role of the DEJ has been determined as skin integrity; there are still aspects of it that are poorly investigated. Tissue engineering (TE) has evolved promising skin regeneration strategies and already developed TE scaffolds for clinical use. However, the currently available skin TE equivalents neglect to replicate the DEJ anatomical structures. The emergent ability to produce increasingly complex scaffolds for skin TE will enable the development of closer physical and physiological mimics to natural skin; it also allows researchers to study the DEJ effect on cell function. Few studies have created patterned substrates that could mimic the human DEJ to explore their significance. Here, we first review the DEJ roles and then critically discuss the TE strategies to create the DEJ undulating structure and their effects. New approaches in this field could be instrumental for improving bioengineered skin substitutes, creating 3D engineered skin, identifying pathological mechanisms, and producing and screening drugs.Mina AleemardaniMichael Zivojin TrikićNicola Helen GreenFrederik ClaeyssensMDPI AGarticledermal-epidermal junctionskin tissue engineeringscaffoldsphysical factorstopographical featuresTechnologyTBiology (General)QH301-705.5ENBioengineering, Vol 8, Iss 148, p 148 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dermal-epidermal junction skin tissue engineering scaffolds physical factors topographical features Technology T Biology (General) QH301-705.5
spellingShingle	dermal-epidermal junction skin tissue engineering scaffolds physical factors topographical features Technology T Biology (General) QH301-705.5 Mina Aleemardani Michael Zivojin Trikić Nicola Helen Green Frederik Claeyssens The Importance of Mimicking Dermal-Epidermal Junction for Skin Tissue Engineering: A Review
description	There is a distinct boundary between the dermis and epidermis in the human skin called the basement membrane, a dense collagen network that creates undulations of the dermal–epidermal junction (DEJ). The DEJ plays multiple roles in skin homeostasis and function, namely, enhancing the adhesion and physical interlock of the layers, creating niches for epidermal stem cells, regulating the cellular microenvironment, and providing a physical boundary layer between fibroblasts and keratinocytes. However, the primary role of the DEJ has been determined as skin integrity; there are still aspects of it that are poorly investigated. Tissue engineering (TE) has evolved promising skin regeneration strategies and already developed TE scaffolds for clinical use. However, the currently available skin TE equivalents neglect to replicate the DEJ anatomical structures. The emergent ability to produce increasingly complex scaffolds for skin TE will enable the development of closer physical and physiological mimics to natural skin; it also allows researchers to study the DEJ effect on cell function. Few studies have created patterned substrates that could mimic the human DEJ to explore their significance. Here, we first review the DEJ roles and then critically discuss the TE strategies to create the DEJ undulating structure and their effects. New approaches in this field could be instrumental for improving bioengineered skin substitutes, creating 3D engineered skin, identifying pathological mechanisms, and producing and screening drugs.
format	article
author	Mina Aleemardani Michael Zivojin Trikić Nicola Helen Green Frederik Claeyssens
author_facet	Mina Aleemardani Michael Zivojin Trikić Nicola Helen Green Frederik Claeyssens
author_sort	Mina Aleemardani
title	The Importance of Mimicking Dermal-Epidermal Junction for Skin Tissue Engineering: A Review
title_short	The Importance of Mimicking Dermal-Epidermal Junction for Skin Tissue Engineering: A Review
title_full	The Importance of Mimicking Dermal-Epidermal Junction for Skin Tissue Engineering: A Review
title_fullStr	The Importance of Mimicking Dermal-Epidermal Junction for Skin Tissue Engineering: A Review
title_full_unstemmed	The Importance of Mimicking Dermal-Epidermal Junction for Skin Tissue Engineering: A Review
title_sort	importance of mimicking dermal-epidermal junction for skin tissue engineering: a review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/20aeb78a3e13471a93b9b4cfe1c9f973
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The Importance of Mimicking Dermal-Epidermal Junction for Skin Tissue Engineering: A Review

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