Effect of Foot-and-Mouth Disease Vaccine on Pregnancy Failure in Beef Cows

This study evaluates whether the foot-and-mouth disease (FMD) vaccination increases pregnancy failures in Bos taurus beef cows. A total of 3,379 cows were assigned to two experimental groups to receive (n = 1,722) or not receive (n = 1,657) a FMD vaccine (commercial preparation containing FMD virus,...

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Autores principales:	Camila Garcia-Pintos, Franklin Riet-Correa, Alejo Menchaca
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	gestation maintenance pregnancy losses embryo mortality abortion FMD vaccine hyperthermia Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/20aebe4cfd8f4ecd90470f590e47f292
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spelling	oai:doaj.org-article:20aebe4cfd8f4ecd90470f590e47f2922021-11-12T05:47:30ZEffect of Foot-and-Mouth Disease Vaccine on Pregnancy Failure in Beef Cows2297-176910.3389/fvets.2021.761304https://doaj.org/article/20aebe4cfd8f4ecd90470f590e47f2922021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fvets.2021.761304/fullhttps://doaj.org/toc/2297-1769This study evaluates whether the foot-and-mouth disease (FMD) vaccination increases pregnancy failures in Bos taurus beef cows. A total of 3,379 cows were assigned to two experimental groups to receive (n = 1,722) or not receive (n = 1,657) a FMD vaccine (commercial preparation containing FMD virus, O1 Campos and A24 Cruzeiro) at different gestational age. Pregnancy diagnosis was performed by ultrasonography at vaccination time (Day 0), and the cows were classified by days of pregnancy as follows: (a) <29 days after mating (presumed pregnant cows, n = 778), (b) between 30 and 44 days of pregnancy (n = 1,100), (c) 45 and 59 days of pregnancy (n = 553), and (d) between 60 and 90 days of pregnancy (n = 948). Pregnancy failure was determined 30 days after vaccination by a second ultrasound examination. Cows that were vaccinated within 29 days after mating had a 7.8% greater pregnancy failure rate than non-vaccinated cows (44.1%, 163/370 vs. 36.3%, 148/408, respectively; P <0.05). Cows vaccinated between 30 and 44 days of gestation had a pregnancy failure rate greater than non-vaccinated cows (4.9%, 28/576 vs. 2.5%, 13/524, respectively; P <0.05). When cows received the vaccine between days 45 and 90 of gestation no differences in pregnancy failure were observed (0.8%, 6/776 vs. 1.2%, 9/725, respectively; P = NS). Body temperature and local adverse reactions to vaccine inoculation were recorded in a subset of 152 multiparous cows. Hyperthermia (>39.5°C) was detected on Day 1 or 2 in 28.0% (21/75) of vaccinated vs. 7.8% (6/77) of non-vaccinated cows (P <0.01). Local adverse reaction to the FMD vaccine inoculation increased from 0.0% (0/75) on Day 0, to 15.7% (11/75) on Day 4, and 38.7% (29/75) on Day 10 (P <0.01). On Day 30 local reaction was detected in 10.5% (34/323) and fell to 2.2% on Day 60 (7/323) post vaccination (P <0.01). In conclusion, FMD vaccine increases pregnancy failure when it is administered before 45 days of gestation, an effect that was associated with hyperthermia and local adverse reaction. No effect on pregnancy failure was found when vaccination was performed after 45 days of gestation.Camila Garcia-PintosCamila Garcia-PintosFranklin Riet-CorreaFranklin Riet-CorreaAlejo MenchacaAlejo MenchacaFrontiers Media S.A.articlegestation maintenancepregnancy lossesembryo mortalityabortionFMD vaccinehyperthermiaVeterinary medicineSF600-1100ENFrontiers in Veterinary Science, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gestation maintenance pregnancy losses embryo mortality abortion FMD vaccine hyperthermia Veterinary medicine SF600-1100
spellingShingle	gestation maintenance pregnancy losses embryo mortality abortion FMD vaccine hyperthermia Veterinary medicine SF600-1100 Camila Garcia-Pintos Camila Garcia-Pintos Franklin Riet-Correa Franklin Riet-Correa Alejo Menchaca Alejo Menchaca Effect of Foot-and-Mouth Disease Vaccine on Pregnancy Failure in Beef Cows
description	This study evaluates whether the foot-and-mouth disease (FMD) vaccination increases pregnancy failures in Bos taurus beef cows. A total of 3,379 cows were assigned to two experimental groups to receive (n = 1,722) or not receive (n = 1,657) a FMD vaccine (commercial preparation containing FMD virus, O1 Campos and A24 Cruzeiro) at different gestational age. Pregnancy diagnosis was performed by ultrasonography at vaccination time (Day 0), and the cows were classified by days of pregnancy as follows: (a) <29 days after mating (presumed pregnant cows, n = 778), (b) between 30 and 44 days of pregnancy (n = 1,100), (c) 45 and 59 days of pregnancy (n = 553), and (d) between 60 and 90 days of pregnancy (n = 948). Pregnancy failure was determined 30 days after vaccination by a second ultrasound examination. Cows that were vaccinated within 29 days after mating had a 7.8% greater pregnancy failure rate than non-vaccinated cows (44.1%, 163/370 vs. 36.3%, 148/408, respectively; P <0.05). Cows vaccinated between 30 and 44 days of gestation had a pregnancy failure rate greater than non-vaccinated cows (4.9%, 28/576 vs. 2.5%, 13/524, respectively; P <0.05). When cows received the vaccine between days 45 and 90 of gestation no differences in pregnancy failure were observed (0.8%, 6/776 vs. 1.2%, 9/725, respectively; P = NS). Body temperature and local adverse reactions to vaccine inoculation were recorded in a subset of 152 multiparous cows. Hyperthermia (>39.5°C) was detected on Day 1 or 2 in 28.0% (21/75) of vaccinated vs. 7.8% (6/77) of non-vaccinated cows (P <0.01). Local adverse reaction to the FMD vaccine inoculation increased from 0.0% (0/75) on Day 0, to 15.7% (11/75) on Day 4, and 38.7% (29/75) on Day 10 (P <0.01). On Day 30 local reaction was detected in 10.5% (34/323) and fell to 2.2% on Day 60 (7/323) post vaccination (P <0.01). In conclusion, FMD vaccine increases pregnancy failure when it is administered before 45 days of gestation, an effect that was associated with hyperthermia and local adverse reaction. No effect on pregnancy failure was found when vaccination was performed after 45 days of gestation.
format	article
author	Camila Garcia-Pintos Camila Garcia-Pintos Franklin Riet-Correa Franklin Riet-Correa Alejo Menchaca Alejo Menchaca
author_facet	Camila Garcia-Pintos Camila Garcia-Pintos Franklin Riet-Correa Franklin Riet-Correa Alejo Menchaca Alejo Menchaca
author_sort	Camila Garcia-Pintos
title	Effect of Foot-and-Mouth Disease Vaccine on Pregnancy Failure in Beef Cows
title_short	Effect of Foot-and-Mouth Disease Vaccine on Pregnancy Failure in Beef Cows
title_full	Effect of Foot-and-Mouth Disease Vaccine on Pregnancy Failure in Beef Cows
title_fullStr	Effect of Foot-and-Mouth Disease Vaccine on Pregnancy Failure in Beef Cows
title_full_unstemmed	Effect of Foot-and-Mouth Disease Vaccine on Pregnancy Failure in Beef Cows
title_sort	effect of foot-and-mouth disease vaccine on pregnancy failure in beef cows
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/20aebe4cfd8f4ecd90470f590e47f292
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Effect of Foot-and-Mouth Disease Vaccine on Pregnancy Failure in Beef Cows

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