Discovery of an ene-reductase for initiating flavone and flavonol catabolism in gut bacteria

Discovery of an ene-reductase for initiating flavone and flavonol catabolism in gut bacteria

Flavonoids are abundant polyphenols in plants but it is not well understood how their metabolism is initiated by microbes in the human gut. Here, the authors identify and characterise an ene-reductase from the gut bacterium, Flavonifractor plautii ATCC 49531 that catalyses the hydrogenation of the C...

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Autores principales: Gaohua Yang, Sen Hong, Pengjie Yang, Yuwei Sun, Yong Wang, Peng Zhang, Weihong Jiang, Yang Gu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/20b0c36a9d084476a6121df172d0f507
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spelling oai:doaj.org-article:20b0c36a9d084476a6121df172d0f5072021-12-02T14:06:10ZDiscovery of an ene-reductase for initiating flavone and flavonol catabolism in gut bacteria10.1038/s41467-021-20974-22041-1723https://doaj.org/article/20b0c36a9d084476a6121df172d0f5072021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-20974-2https://doaj.org/toc/2041-1723Flavonoids are abundant polyphenols in plants but it is not well understood how their metabolism is initiated by microbes in the human gut. Here, the authors identify and characterise an ene-reductase from the gut bacterium, Flavonifractor plautii ATCC 49531 that catalyses the hydrogenation of the C2–C3 double bond of flavones and flavonols and present its crystal structure.Gaohua YangSen HongPengjie YangYuwei SunYong WangPeng ZhangWeihong JiangYang GuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Gaohua Yang
Sen Hong
Pengjie Yang
Yuwei Sun
Yong Wang
Peng Zhang
Weihong Jiang
Yang Gu
Discovery of an ene-reductase for initiating flavone and flavonol catabolism in gut bacteria
description Flavonoids are abundant polyphenols in plants but it is not well understood how their metabolism is initiated by microbes in the human gut. Here, the authors identify and characterise an ene-reductase from the gut bacterium, Flavonifractor plautii ATCC 49531 that catalyses the hydrogenation of the C2–C3 double bond of flavones and flavonols and present its crystal structure.
format article
author Gaohua Yang
Sen Hong
Pengjie Yang
Yuwei Sun
Yong Wang
Peng Zhang
Weihong Jiang
Yang Gu
author_facet Gaohua Yang
Sen Hong
Pengjie Yang
Yuwei Sun
Yong Wang
Peng Zhang
Weihong Jiang
Yang Gu
author_sort Gaohua Yang
title Discovery of an ene-reductase for initiating flavone and flavonol catabolism in gut bacteria
title_short Discovery of an ene-reductase for initiating flavone and flavonol catabolism in gut bacteria
title_full Discovery of an ene-reductase for initiating flavone and flavonol catabolism in gut bacteria
title_fullStr Discovery of an ene-reductase for initiating flavone and flavonol catabolism in gut bacteria
title_full_unstemmed Discovery of an ene-reductase for initiating flavone and flavonol catabolism in gut bacteria
title_sort discovery of an ene-reductase for initiating flavone and flavonol catabolism in gut bacteria
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/20b0c36a9d084476a6121df172d0f507
work_keys_str_mv AT gaohuayang discoveryofanenereductaseforinitiatingflavoneandflavonolcatabolismingutbacteria
AT senhong discoveryofanenereductaseforinitiatingflavoneandflavonolcatabolismingutbacteria
AT pengjieyang discoveryofanenereductaseforinitiatingflavoneandflavonolcatabolismingutbacteria
AT yuweisun discoveryofanenereductaseforinitiatingflavoneandflavonolcatabolismingutbacteria
AT yongwang discoveryofanenereductaseforinitiatingflavoneandflavonolcatabolismingutbacteria
AT pengzhang discoveryofanenereductaseforinitiatingflavoneandflavonolcatabolismingutbacteria
AT weihongjiang discoveryofanenereductaseforinitiatingflavoneandflavonolcatabolismingutbacteria
AT yanggu discoveryofanenereductaseforinitiatingflavoneandflavonolcatabolismingutbacteria
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