Molecular basis for assembly of the shieldin complex and its implications for NHEJ

Shieldin, including SHLD1, SHLD2, SHLD3 and REV7, functions to suppress the DNA termini nucleolytic resection during non-homologous end joining (NHEJ). Here the authors present the crystal structure of the SHLD3-REV7-SHLD2 ternary complex revealing insights into the mechanism of the complex.

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Autores principales:	Ling Liang, Jiawen Feng, Peng Zuo, Juan Yang, Yishuo Lu, Yuxin Yin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/20b158b33c4d419c81879ef1d5f5f93a
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spelling	oai:doaj.org-article:20b158b33c4d419c81879ef1d5f5f93a2021-12-02T15:39:27ZMolecular basis for assembly of the shieldin complex and its implications for NHEJ10.1038/s41467-020-15879-52041-1723https://doaj.org/article/20b158b33c4d419c81879ef1d5f5f93a2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15879-5https://doaj.org/toc/2041-1723Shieldin, including SHLD1, SHLD2, SHLD3 and REV7, functions to suppress the DNA termini nucleolytic resection during non-homologous end joining (NHEJ). Here the authors present the crystal structure of the SHLD3-REV7-SHLD2 ternary complex revealing insights into the mechanism of the complex.Ling LiangJiawen FengPeng ZuoJuan YangYishuo LuYuxin YinNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ling Liang Jiawen Feng Peng Zuo Juan Yang Yishuo Lu Yuxin Yin Molecular basis for assembly of the shieldin complex and its implications for NHEJ
description	Shieldin, including SHLD1, SHLD2, SHLD3 and REV7, functions to suppress the DNA termini nucleolytic resection during non-homologous end joining (NHEJ). Here the authors present the crystal structure of the SHLD3-REV7-SHLD2 ternary complex revealing insights into the mechanism of the complex.
format	article
author	Ling Liang Jiawen Feng Peng Zuo Juan Yang Yishuo Lu Yuxin Yin
author_facet	Ling Liang Jiawen Feng Peng Zuo Juan Yang Yishuo Lu Yuxin Yin
author_sort	Ling Liang
title	Molecular basis for assembly of the shieldin complex and its implications for NHEJ
title_short	Molecular basis for assembly of the shieldin complex and its implications for NHEJ
title_full	Molecular basis for assembly of the shieldin complex and its implications for NHEJ
title_fullStr	Molecular basis for assembly of the shieldin complex and its implications for NHEJ
title_full_unstemmed	Molecular basis for assembly of the shieldin complex and its implications for NHEJ
title_sort	molecular basis for assembly of the shieldin complex and its implications for nhej
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/20b158b33c4d419c81879ef1d5f5f93a
work_keys_str_mv	AT lingliang molecularbasisforassemblyoftheshieldincomplexanditsimplicationsfornhej AT jiawenfeng molecularbasisforassemblyoftheshieldincomplexanditsimplicationsfornhej AT pengzuo molecularbasisforassemblyoftheshieldincomplexanditsimplicationsfornhej AT juanyang molecularbasisforassemblyoftheshieldincomplexanditsimplicationsfornhej AT yishuolu molecularbasisforassemblyoftheshieldincomplexanditsimplicationsfornhej AT yuxinyin molecularbasisforassemblyoftheshieldincomplexanditsimplicationsfornhej
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Molecular basis for assembly of the shieldin complex and its implications for NHEJ

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