Molecular basis for assembly of the shieldin complex and its implications for NHEJ

Molecular basis for assembly of the shieldin complex and its implications for NHEJ

Shieldin, including SHLD1, SHLD2, SHLD3 and REV7, functions to suppress the DNA termini nucleolytic resection during non-homologous end joining (NHEJ). Here the authors present the crystal structure of the SHLD3-REV7-SHLD2 ternary complex revealing insights into the mechanism of the complex.

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Autores principales: Ling Liang, Jiawen Feng, Peng Zuo, Juan Yang, Yishuo Lu, Yuxin Yin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
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Acceso en línea:https://doaj.org/article/20b158b33c4d419c81879ef1d5f5f93a
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