The KDM3A–KLF2–IRF4 axis maintains myeloma cell survival
Several histone modifiers have been implicated in the survival of multiple myeloma cells. Here, the authors reveal a role for the histone demethylase KDM3A in the survival of this haematologic cancer, and show that mechanistically KDM3A removes H3K9 methylation from the promoters of KLF2 and IRF4, g...
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Nature Portfolio
2016
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oai:doaj.org-article:20b2f18e02d546e98af32ec37b4cedf82021-12-02T16:49:41ZThe KDM3A–KLF2–IRF4 axis maintains myeloma cell survival10.1038/ncomms102582041-1723https://doaj.org/article/20b2f18e02d546e98af32ec37b4cedf82016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10258https://doaj.org/toc/2041-1723Several histone modifiers have been implicated in the survival of multiple myeloma cells. Here, the authors reveal a role for the histone demethylase KDM3A in the survival of this haematologic cancer, and show that mechanistically KDM3A removes H3K9 methylation from the promoters of KLF2 and IRF4, genes essential for myeloma cell survival.Hiroto OhguchiTeru HideshimaManoj K. BhasinGullu T. GorgunLoredana SantoMichele CeaMehmet K. SamurNaoya MimuraRikio SuzukiYu-Tzu TaiRuben D. CarrascoNoopur RajePaul G. RichardsonNikhil C. MunshiHideo HarigaeTakaomi SandaJuro SakaiKenneth C. AndersonNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016) |
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Science Q |
| spellingShingle |
Science Q Hiroto Ohguchi Teru Hideshima Manoj K. Bhasin Gullu T. Gorgun Loredana Santo Michele Cea Mehmet K. Samur Naoya Mimura Rikio Suzuki Yu-Tzu Tai Ruben D. Carrasco Noopur Raje Paul G. Richardson Nikhil C. Munshi Hideo Harigae Takaomi Sanda Juro Sakai Kenneth C. Anderson The KDM3A–KLF2–IRF4 axis maintains myeloma cell survival |
| description |
Several histone modifiers have been implicated in the survival of multiple myeloma cells. Here, the authors reveal a role for the histone demethylase KDM3A in the survival of this haematologic cancer, and show that mechanistically KDM3A removes H3K9 methylation from the promoters of KLF2 and IRF4, genes essential for myeloma cell survival. |
| format |
article |
| author |
Hiroto Ohguchi Teru Hideshima Manoj K. Bhasin Gullu T. Gorgun Loredana Santo Michele Cea Mehmet K. Samur Naoya Mimura Rikio Suzuki Yu-Tzu Tai Ruben D. Carrasco Noopur Raje Paul G. Richardson Nikhil C. Munshi Hideo Harigae Takaomi Sanda Juro Sakai Kenneth C. Anderson |
| author_facet |
Hiroto Ohguchi Teru Hideshima Manoj K. Bhasin Gullu T. Gorgun Loredana Santo Michele Cea Mehmet K. Samur Naoya Mimura Rikio Suzuki Yu-Tzu Tai Ruben D. Carrasco Noopur Raje Paul G. Richardson Nikhil C. Munshi Hideo Harigae Takaomi Sanda Juro Sakai Kenneth C. Anderson |
| author_sort |
Hiroto Ohguchi |
| title |
The KDM3A–KLF2–IRF4 axis maintains myeloma cell survival |
| title_short |
The KDM3A–KLF2–IRF4 axis maintains myeloma cell survival |
| title_full |
The KDM3A–KLF2–IRF4 axis maintains myeloma cell survival |
| title_fullStr |
The KDM3A–KLF2–IRF4 axis maintains myeloma cell survival |
| title_full_unstemmed |
The KDM3A–KLF2–IRF4 axis maintains myeloma cell survival |
| title_sort |
kdm3a–klf2–irf4 axis maintains myeloma cell survival |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/20b2f18e02d546e98af32ec37b4cedf8 |
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