Correlations between autoantibodies and the ATR-FTIR spectra of sera from rheumatoid arthritis patients

Abstract Rheumatoid arthritis (RA) is one of the most common autoimmune diseases worldwide. Due to high heterogeneity in disease manifestation, accurate and fast diagnosis of RA is difficult. This study analyzed the potential relationship between the infrared (IR) spectra obtained by attenuated tota...

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Autores principales:	Katarzyna Durlik-Popińska, Paulina Żarnowiec, Iwona Konieczna-Kwinkowska, Łukasz Lechowicz, Józef Gawęda, Wiesław Kaca
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/20b490a49db94ae69dc1c5d984f57202
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spelling	oai:doaj.org-article:20b490a49db94ae69dc1c5d984f572022021-12-02T17:41:18ZCorrelations between autoantibodies and the ATR-FTIR spectra of sera from rheumatoid arthritis patients10.1038/s41598-021-96848-w2045-2322https://doaj.org/article/20b490a49db94ae69dc1c5d984f572022021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96848-whttps://doaj.org/toc/2045-2322Abstract Rheumatoid arthritis (RA) is one of the most common autoimmune diseases worldwide. Due to high heterogeneity in disease manifestation, accurate and fast diagnosis of RA is difficult. This study analyzed the potential relationship between the infrared (IR) spectra obtained by attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and the presence of autoantibodies and antibodies against urease in sera. Additionally, the wave number of the IR spectrum that enabled the best differentiation between patients and healthy blood donors was investigated. Using a mathematical model involving principal component analysis and discriminant analysis, it was shown that the presence of anti-citrullinated protein antibody, rheumatoid factor, anti-neutrophil cytoplasmic antibodies, and anti-nuclear antibodies correlated significantly with the wave numbers in the IR spectra of the tested sera. The most interesting findings derived from determination of the best predictors for distinguishing RA. Characteristic features included an increased reaction with urease mimicking peptides and a correspondence with particular nucleic acid bands. Taken together, the results demonstrated the potential application of ATR-FTIR in the study of RA and identified potential novel markers of the disease.Katarzyna Durlik-PopińskaPaulina ŻarnowiecIwona Konieczna-KwinkowskaŁukasz LechowiczJózef GawędaWiesław KacaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Katarzyna Durlik-Popińska Paulina Żarnowiec Iwona Konieczna-Kwinkowska Łukasz Lechowicz Józef Gawęda Wiesław Kaca Correlations between autoantibodies and the ATR-FTIR spectra of sera from rheumatoid arthritis patients
description	Abstract Rheumatoid arthritis (RA) is one of the most common autoimmune diseases worldwide. Due to high heterogeneity in disease manifestation, accurate and fast diagnosis of RA is difficult. This study analyzed the potential relationship between the infrared (IR) spectra obtained by attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and the presence of autoantibodies and antibodies against urease in sera. Additionally, the wave number of the IR spectrum that enabled the best differentiation between patients and healthy blood donors was investigated. Using a mathematical model involving principal component analysis and discriminant analysis, it was shown that the presence of anti-citrullinated protein antibody, rheumatoid factor, anti-neutrophil cytoplasmic antibodies, and anti-nuclear antibodies correlated significantly with the wave numbers in the IR spectra of the tested sera. The most interesting findings derived from determination of the best predictors for distinguishing RA. Characteristic features included an increased reaction with urease mimicking peptides and a correspondence with particular nucleic acid bands. Taken together, the results demonstrated the potential application of ATR-FTIR in the study of RA and identified potential novel markers of the disease.
format	article
author	Katarzyna Durlik-Popińska Paulina Żarnowiec Iwona Konieczna-Kwinkowska Łukasz Lechowicz Józef Gawęda Wiesław Kaca
author_facet	Katarzyna Durlik-Popińska Paulina Żarnowiec Iwona Konieczna-Kwinkowska Łukasz Lechowicz Józef Gawęda Wiesław Kaca
author_sort	Katarzyna Durlik-Popińska
title	Correlations between autoantibodies and the ATR-FTIR spectra of sera from rheumatoid arthritis patients
title_short	Correlations between autoantibodies and the ATR-FTIR spectra of sera from rheumatoid arthritis patients
title_full	Correlations between autoantibodies and the ATR-FTIR spectra of sera from rheumatoid arthritis patients
title_fullStr	Correlations between autoantibodies and the ATR-FTIR spectra of sera from rheumatoid arthritis patients
title_full_unstemmed	Correlations between autoantibodies and the ATR-FTIR spectra of sera from rheumatoid arthritis patients
title_sort	correlations between autoantibodies and the atr-ftir spectra of sera from rheumatoid arthritis patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/20b490a49db94ae69dc1c5d984f57202
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Correlations between autoantibodies and the ATR-FTIR spectra of sera from rheumatoid arthritis patients

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