An alternative CTCF isoform antagonizes canonical CTCF occupancy and changes chromatin architecture to promote apoptosis

An alternative CTCF isoform antagonizes canonical CTCF occupancy and changes chromatin architecture to promote apoptosis

CTCF plays key roles in gene regulation, chromatin insulation and organizing the higher-order chromatin architecture of mammalian genomes. Here the authors investigate the function an alternatively spliced shorter CTCF isoform, finding that this isoform antagonizes canonical CTCF occupancy and chang...

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Autores principales: Jiao Li, Kaimeng Huang, Gongcheng Hu, Isaac A. Babarinde, Yaoyi Li, Xiaotao Dong, Yu-Sheng Chen, Liping Shang, Wenjing Guo, Junwei Wang, Zhaoming Chen, Andrew P. Hutchins, Yun-Gui Yang, Hongjie Yao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/20b7e015e06445819e1fb1c7fa1b68e6
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spelling oai:doaj.org-article:20b7e015e06445819e1fb1c7fa1b68e62021-12-02T17:01:55ZAn alternative CTCF isoform antagonizes canonical CTCF occupancy and changes chromatin architecture to promote apoptosis10.1038/s41467-019-08949-w2041-1723https://doaj.org/article/20b7e015e06445819e1fb1c7fa1b68e62019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08949-whttps://doaj.org/toc/2041-1723CTCF plays key roles in gene regulation, chromatin insulation and organizing the higher-order chromatin architecture of mammalian genomes. Here the authors investigate the function an alternatively spliced shorter CTCF isoform, finding that this isoform antagonizes canonical CTCF occupancy and changes chromatin architecture to promote apoptosis.Jiao LiKaimeng HuangGongcheng HuIsaac A. BabarindeYaoyi LiXiaotao DongYu-Sheng ChenLiping ShangWenjing GuoJunwei WangZhaoming ChenAndrew P. HutchinsYun-Gui YangHongjie YaoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jiao Li
Kaimeng Huang
Gongcheng Hu
Isaac A. Babarinde
Yaoyi Li
Xiaotao Dong
Yu-Sheng Chen
Liping Shang
Wenjing Guo
Junwei Wang
Zhaoming Chen
Andrew P. Hutchins
Yun-Gui Yang
Hongjie Yao
An alternative CTCF isoform antagonizes canonical CTCF occupancy and changes chromatin architecture to promote apoptosis
description CTCF plays key roles in gene regulation, chromatin insulation and organizing the higher-order chromatin architecture of mammalian genomes. Here the authors investigate the function an alternatively spliced shorter CTCF isoform, finding that this isoform antagonizes canonical CTCF occupancy and changes chromatin architecture to promote apoptosis.
format article
author Jiao Li
Kaimeng Huang
Gongcheng Hu
Isaac A. Babarinde
Yaoyi Li
Xiaotao Dong
Yu-Sheng Chen
Liping Shang
Wenjing Guo
Junwei Wang
Zhaoming Chen
Andrew P. Hutchins
Yun-Gui Yang
Hongjie Yao
author_facet Jiao Li
Kaimeng Huang
Gongcheng Hu
Isaac A. Babarinde
Yaoyi Li
Xiaotao Dong
Yu-Sheng Chen
Liping Shang
Wenjing Guo
Junwei Wang
Zhaoming Chen
Andrew P. Hutchins
Yun-Gui Yang
Hongjie Yao
author_sort Jiao Li
title An alternative CTCF isoform antagonizes canonical CTCF occupancy and changes chromatin architecture to promote apoptosis
title_short An alternative CTCF isoform antagonizes canonical CTCF occupancy and changes chromatin architecture to promote apoptosis
title_full An alternative CTCF isoform antagonizes canonical CTCF occupancy and changes chromatin architecture to promote apoptosis
title_fullStr An alternative CTCF isoform antagonizes canonical CTCF occupancy and changes chromatin architecture to promote apoptosis
title_full_unstemmed An alternative CTCF isoform antagonizes canonical CTCF occupancy and changes chromatin architecture to promote apoptosis
title_sort alternative ctcf isoform antagonizes canonical ctcf occupancy and changes chromatin architecture to promote apoptosis
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/20b7e015e06445819e1fb1c7fa1b68e6
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