An alternative CTCF isoform antagonizes canonical CTCF occupancy and changes chromatin architecture to promote apoptosis
CTCF plays key roles in gene regulation, chromatin insulation and organizing the higher-order chromatin architecture of mammalian genomes. Here the authors investigate the function an alternatively spliced shorter CTCF isoform, finding that this isoform antagonizes canonical CTCF occupancy and chang...
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Main Authors: | Jiao Li, Kaimeng Huang, Gongcheng Hu, Isaac A. Babarinde, Yaoyi Li, Xiaotao Dong, Yu-Sheng Chen, Liping Shang, Wenjing Guo, Junwei Wang, Zhaoming Chen, Andrew P. Hutchins, Yun-Gui Yang, Hongjie Yao |
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Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2019
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Online Access: | https://doaj.org/article/20b7e015e06445819e1fb1c7fa1b68e6 |
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