Preparation and characterization of solid lipid nanoparticles loaded with frankincense and myrrh oil

Feng Shi, Ji-Hui Zhao, Ying Liu, Zhi Wang, Yong-Tai Zhang, Nian-Ping FengSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People&#39;s Republic of ChinaAbstract: The aim of the present study was to prepare solid lipid nanoparticles (SLNs) for the oral delive...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Shi F, Zhao JH, Liu Y, Wang Z, Zhang YT, Feng NP
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/20ba73702d6140d3bc3986b130429a66
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:20ba73702d6140d3bc3986b130429a66
record_format	dspace
spelling	oai:doaj.org-article:20ba73702d6140d3bc3986b130429a662021-12-02T00:12:16ZPreparation and characterization of solid lipid nanoparticles loaded with frankincense and myrrh oil1176-91141178-2013https://doaj.org/article/20ba73702d6140d3bc3986b130429a662012-04-01T00:00:00Zhttp://www.dovepress.com/preparation-and-characterization-of-solid-lipid-nanoparticles-loaded-w-a9719https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Feng Shi, Ji-Hui Zhao, Ying Liu, Zhi Wang, Yong-Tai Zhang, Nian-Ping FengSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People&#39;s Republic of ChinaAbstract: The aim of the present study was to prepare solid lipid nanoparticles (SLNs) for the oral delivery of frankincense and myrrh essential oils (FMO). Aqueous dispersions of SLNs were successfully prepared by a high-pressure homogenization method using Compritol 888 ATO as the solid lipid and soybean lecithin and Tween 80 as the surfactants. The properties of the SLNs such as particle size, zeta potential (ZP), and drug encapsulation efficiency (EE) were investigated. The morphology of SLNs was observed by transmission electron microscopy (TEM). The crystallinity of the formulation was analyzed by differential scanning calorimetry (DSC) and X-ray diffraction (XRD). In addition, drug evaporation release and antitumor activity were also studied. Round SLNs with a mean size of 113.3 &plusmn; 3.6 nm, a ZP of -16.8 &plusmn; 0.4 mV, and an EE of 80.60% &plusmn; 1.11% were obtained. DSC and XRD measurements revealed that less ordered structures were formed in the inner cores of the SLN particles. Evaporation loss of the active components in FMO could be reduced in the SLNs. Furthermore, the SLN formulation increased the antitumor efficacy of FMO in H22-bearing Kunming mice. Hence, the presented SLNs can be used as drug carriers for hydrophobic oil drugs extracted from traditional Chinese medicines.Keywords: solid lipid nanoparticles, frankincense oil, myrrh oil, evaporation release, antitumor activity, traditional Chinese medicineShi FZhao JHLiu YWang ZZhang YTFeng NPDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 2033-2043 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Shi F Zhao JH Liu Y Wang Z Zhang YT Feng NP Preparation and characterization of solid lipid nanoparticles loaded with frankincense and myrrh oil
description	Feng Shi, Ji-Hui Zhao, Ying Liu, Zhi Wang, Yong-Tai Zhang, Nian-Ping FengSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People&#39;s Republic of ChinaAbstract: The aim of the present study was to prepare solid lipid nanoparticles (SLNs) for the oral delivery of frankincense and myrrh essential oils (FMO). Aqueous dispersions of SLNs were successfully prepared by a high-pressure homogenization method using Compritol 888 ATO as the solid lipid and soybean lecithin and Tween 80 as the surfactants. The properties of the SLNs such as particle size, zeta potential (ZP), and drug encapsulation efficiency (EE) were investigated. The morphology of SLNs was observed by transmission electron microscopy (TEM). The crystallinity of the formulation was analyzed by differential scanning calorimetry (DSC) and X-ray diffraction (XRD). In addition, drug evaporation release and antitumor activity were also studied. Round SLNs with a mean size of 113.3 &plusmn; 3.6 nm, a ZP of -16.8 &plusmn; 0.4 mV, and an EE of 80.60% &plusmn; 1.11% were obtained. DSC and XRD measurements revealed that less ordered structures were formed in the inner cores of the SLN particles. Evaporation loss of the active components in FMO could be reduced in the SLNs. Furthermore, the SLN formulation increased the antitumor efficacy of FMO in H22-bearing Kunming mice. Hence, the presented SLNs can be used as drug carriers for hydrophobic oil drugs extracted from traditional Chinese medicines.Keywords: solid lipid nanoparticles, frankincense oil, myrrh oil, evaporation release, antitumor activity, traditional Chinese medicine
format	article
author	Shi F Zhao JH Liu Y Wang Z Zhang YT Feng NP
author_facet	Shi F Zhao JH Liu Y Wang Z Zhang YT Feng NP
author_sort	Shi F
title	Preparation and characterization of solid lipid nanoparticles loaded with frankincense and myrrh oil
title_short	Preparation and characterization of solid lipid nanoparticles loaded with frankincense and myrrh oil
title_full	Preparation and characterization of solid lipid nanoparticles loaded with frankincense and myrrh oil
title_fullStr	Preparation and characterization of solid lipid nanoparticles loaded with frankincense and myrrh oil
title_full_unstemmed	Preparation and characterization of solid lipid nanoparticles loaded with frankincense and myrrh oil
title_sort	preparation and characterization of solid lipid nanoparticles loaded with frankincense and myrrh oil
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/20ba73702d6140d3bc3986b130429a66
work_keys_str_mv	AT shif preparationandcharacterizationofsolidlipidnanoparticlesloadedwithfrankincenseandmyrrhoil AT zhaojh preparationandcharacterizationofsolidlipidnanoparticlesloadedwithfrankincenseandmyrrhoil AT liuy preparationandcharacterizationofsolidlipidnanoparticlesloadedwithfrankincenseandmyrrhoil AT wangz preparationandcharacterizationofsolidlipidnanoparticlesloadedwithfrankincenseandmyrrhoil AT zhangyt preparationandcharacterizationofsolidlipidnanoparticlesloadedwithfrankincenseandmyrrhoil AT fengnp preparationandcharacterizationofsolidlipidnanoparticlesloadedwithfrankincenseandmyrrhoil
_version_	1718403851035344896

Preparation and characterization of solid lipid nanoparticles loaded with frankincense and myrrh oil

Ejemplares similares