Correlation of platelet parameters with adverse maternal and neonatal outcomes in severe preeclampsia: A case-control study

Background: Pre-eclampsia (PET) is a potentially devastating multi-systemic disorder resulting in the generation of oxidative stress. Platelet activation causes vasoconstriction and release of inflammatory cytokines, resulting in an intensified inflammatory response, endothelial damage, and coagulop...

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Autores principales:	Benjamin S. Umezuluike, Chidebe C. Anikwe, Oluomachi C. Nnachi, Bobbie C.A. Iwe, Chinedu C. Ifemelumma, Ikechukwu B.O. Dimejesi
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Pre-eclampsia Platelet parameters Adverse maternal and perinatal outcomes Science (General) Q1-390 Social sciences (General) H1-99
Acceso en línea:	https://doaj.org/article/20bd8083e2d14f60aff96d3af133f5bd
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spelling	oai:doaj.org-article:20bd8083e2d14f60aff96d3af133f5bd2021-12-02T05:03:24ZCorrelation of platelet parameters with adverse maternal and neonatal outcomes in severe preeclampsia: A case-control study2405-844010.1016/j.heliyon.2021.e08484https://doaj.org/article/20bd8083e2d14f60aff96d3af133f5bd2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2405844021025871https://doaj.org/toc/2405-8440Background: Pre-eclampsia (PET) is a potentially devastating multi-systemic disorder resulting in the generation of oxidative stress. Platelet activation causes vasoconstriction and release of inflammatory cytokines, resulting in an intensified inflammatory response, endothelial damage, and coagulopathy which culminate in adverse pregnancy outcomes. Aim: To compare the platelet parameters between preeclamptic and normotensive pregnant women and their relationship to adverse outcomes in women with pre-eclampsia. Materials and methods: This was a case-control study of platelet indices of 60 pre-eclamptic and 60 normotensive pregnant women recruited at 28 weeks and followed till delivery. A blood sample was collected at entry into the study and just before delivery. The sample was analyzed within 1 h of collection using the Mythic 18 hematological auto-analyzer. Data were analyzed using IBM-SPSS version 22. A P-value of <0.05 was considered statistically significant. Results: The mean platelet count, Platelet distribution width (PDW), plateletcrit were statistically significantly different between normotensive and severe preeclamptic participants (p= <0.001). Statistically significant differences were not present in any of the platelet parameters between mild and severe PET. The odds of developing eclampsia was low at higher mean platelet count and plateletcrit levels above 161.36 ± 73.74 × 109/L [p = 0.02, AOR = 0.27, 95% CI (0.08–0.88)] and 0.13 ± 0.05% [p = 0.001, AOR = 0.22, 95% CI (0.08–0.58)] respectively. Eclampsia was strongly associated with P-LCR (platelet-large cell ratio) above 23.15 ± 4.92% [p = 0.004, AOR = 11.00, 95%CI (1.48–89.02)]. Abruptio placentae had low odds at lower levels of mean plateletcrit. Pre-term birth was significantly lower at mean plateletcrit levels above 0.14 ± 0.05%; admission into neonatal intensive care unit was strongly associated with a mean PLC ratio above 22.73 ± 5.91%. Conclusion: This study demonstrated significant differences in platelet count, plateletcrit, platelet distribution width, and P-LCR between pre-eclamptic and normotensive women. Increase in P-LCR is a risk factor for eclampsia although the effect size is low.Benjamin S. UmezuluikeChidebe C. AnikweOluomachi C. NnachiBobbie C.A. IweChinedu C. IfemelummaIkechukwu B.O. DimejesiElsevierarticlePre-eclampsiaPlatelet parametersAdverse maternal and perinatal outcomesScience (General)Q1-390Social sciences (General)H1-99ENHeliyon, Vol 7, Iss 12, Pp e08484- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pre-eclampsia Platelet parameters Adverse maternal and perinatal outcomes Science (General) Q1-390 Social sciences (General) H1-99
spellingShingle	Pre-eclampsia Platelet parameters Adverse maternal and perinatal outcomes Science (General) Q1-390 Social sciences (General) H1-99 Benjamin S. Umezuluike Chidebe C. Anikwe Oluomachi C. Nnachi Bobbie C.A. Iwe Chinedu C. Ifemelumma Ikechukwu B.O. Dimejesi Correlation of platelet parameters with adverse maternal and neonatal outcomes in severe preeclampsia: A case-control study
description	Background: Pre-eclampsia (PET) is a potentially devastating multi-systemic disorder resulting in the generation of oxidative stress. Platelet activation causes vasoconstriction and release of inflammatory cytokines, resulting in an intensified inflammatory response, endothelial damage, and coagulopathy which culminate in adverse pregnancy outcomes. Aim: To compare the platelet parameters between preeclamptic and normotensive pregnant women and their relationship to adverse outcomes in women with pre-eclampsia. Materials and methods: This was a case-control study of platelet indices of 60 pre-eclamptic and 60 normotensive pregnant women recruited at 28 weeks and followed till delivery. A blood sample was collected at entry into the study and just before delivery. The sample was analyzed within 1 h of collection using the Mythic 18 hematological auto-analyzer. Data were analyzed using IBM-SPSS version 22. A P-value of <0.05 was considered statistically significant. Results: The mean platelet count, Platelet distribution width (PDW), plateletcrit were statistically significantly different between normotensive and severe preeclamptic participants (p= <0.001). Statistically significant differences were not present in any of the platelet parameters between mild and severe PET. The odds of developing eclampsia was low at higher mean platelet count and plateletcrit levels above 161.36 ± 73.74 × 109/L [p = 0.02, AOR = 0.27, 95% CI (0.08–0.88)] and 0.13 ± 0.05% [p = 0.001, AOR = 0.22, 95% CI (0.08–0.58)] respectively. Eclampsia was strongly associated with P-LCR (platelet-large cell ratio) above 23.15 ± 4.92% [p = 0.004, AOR = 11.00, 95%CI (1.48–89.02)]. Abruptio placentae had low odds at lower levels of mean plateletcrit. Pre-term birth was significantly lower at mean plateletcrit levels above 0.14 ± 0.05%; admission into neonatal intensive care unit was strongly associated with a mean PLC ratio above 22.73 ± 5.91%. Conclusion: This study demonstrated significant differences in platelet count, plateletcrit, platelet distribution width, and P-LCR between pre-eclamptic and normotensive women. Increase in P-LCR is a risk factor for eclampsia although the effect size is low.
format	article
author	Benjamin S. Umezuluike Chidebe C. Anikwe Oluomachi C. Nnachi Bobbie C.A. Iwe Chinedu C. Ifemelumma Ikechukwu B.O. Dimejesi
author_facet	Benjamin S. Umezuluike Chidebe C. Anikwe Oluomachi C. Nnachi Bobbie C.A. Iwe Chinedu C. Ifemelumma Ikechukwu B.O. Dimejesi
author_sort	Benjamin S. Umezuluike
title	Correlation of platelet parameters with adverse maternal and neonatal outcomes in severe preeclampsia: A case-control study
title_short	Correlation of platelet parameters with adverse maternal and neonatal outcomes in severe preeclampsia: A case-control study
title_full	Correlation of platelet parameters with adverse maternal and neonatal outcomes in severe preeclampsia: A case-control study
title_fullStr	Correlation of platelet parameters with adverse maternal and neonatal outcomes in severe preeclampsia: A case-control study
title_full_unstemmed	Correlation of platelet parameters with adverse maternal and neonatal outcomes in severe preeclampsia: A case-control study
title_sort	correlation of platelet parameters with adverse maternal and neonatal outcomes in severe preeclampsia: a case-control study
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/20bd8083e2d14f60aff96d3af133f5bd
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Correlation of platelet parameters with adverse maternal and neonatal outcomes in severe preeclampsia: A case-control study

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