Aromatic C-H addition of ketones to imines enabled by manganese catalysis

The Mannich reaction proceeds by functionalization of C(sp3)-H bonds alpha to carbonyls. Here, the authors suppress the Mannich reactivity of acetophenones in presence of a manganese catalyst and obtain valuable o-aminoalkylacetophenones and isoindolines via C(sp2)-H functionalization with imines.

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Autores principales:	Bingwei Zhou, Yuanyuan Hu, Ting Liu, Congyang Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/20c2a944a63746be8193d3b2717ff70f
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spelling	oai:doaj.org-article:20c2a944a63746be8193d3b2717ff70f2021-12-02T14:42:16ZAromatic C-H addition of ketones to imines enabled by manganese catalysis10.1038/s41467-017-01262-42041-1723https://doaj.org/article/20c2a944a63746be8193d3b2717ff70f2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01262-4https://doaj.org/toc/2041-1723The Mannich reaction proceeds by functionalization of C(sp3)-H bonds alpha to carbonyls. Here, the authors suppress the Mannich reactivity of acetophenones in presence of a manganese catalyst and obtain valuable o-aminoalkylacetophenones and isoindolines via C(sp2)-H functionalization with imines.Bingwei ZhouYuanyuan HuTing LiuCongyang WangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bingwei Zhou Yuanyuan Hu Ting Liu Congyang Wang Aromatic C-H addition of ketones to imines enabled by manganese catalysis
description	The Mannich reaction proceeds by functionalization of C(sp3)-H bonds alpha to carbonyls. Here, the authors suppress the Mannich reactivity of acetophenones in presence of a manganese catalyst and obtain valuable o-aminoalkylacetophenones and isoindolines via C(sp2)-H functionalization with imines.
format	article
author	Bingwei Zhou Yuanyuan Hu Ting Liu Congyang Wang
author_facet	Bingwei Zhou Yuanyuan Hu Ting Liu Congyang Wang
author_sort	Bingwei Zhou
title	Aromatic C-H addition of ketones to imines enabled by manganese catalysis
title_short	Aromatic C-H addition of ketones to imines enabled by manganese catalysis
title_full	Aromatic C-H addition of ketones to imines enabled by manganese catalysis
title_fullStr	Aromatic C-H addition of ketones to imines enabled by manganese catalysis
title_full_unstemmed	Aromatic C-H addition of ketones to imines enabled by manganese catalysis
title_sort	aromatic c-h addition of ketones to imines enabled by manganese catalysis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/20c2a944a63746be8193d3b2717ff70f
work_keys_str_mv	AT bingweizhou aromaticchadditionofketonestoiminesenabledbymanganesecatalysis AT yuanyuanhu aromaticchadditionofketonestoiminesenabledbymanganesecatalysis AT tingliu aromaticchadditionofketonestoiminesenabledbymanganesecatalysis AT congyangwang aromaticchadditionofketonestoiminesenabledbymanganesecatalysis
_version_	1718389738280321024

Aromatic C-H addition of ketones to imines enabled by manganese catalysis

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