Aromatic C-H addition of ketones to imines enabled by manganese catalysis

The Mannich reaction proceeds by functionalization of C(sp3)-H bonds alpha to carbonyls. Here, the authors suppress the Mannich reactivity of acetophenones in presence of a manganese catalyst and obtain valuable o-aminoalkylacetophenones and isoindolines via C(sp2)-H functionalization with imines.

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Autores principales: Bingwei Zhou, Yuanyuan Hu, Ting Liu, Congyang Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/20c2a944a63746be8193d3b2717ff70f
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spelling oai:doaj.org-article:20c2a944a63746be8193d3b2717ff70f2021-12-02T14:42:16ZAromatic C-H addition of ketones to imines enabled by manganese catalysis10.1038/s41467-017-01262-42041-1723https://doaj.org/article/20c2a944a63746be8193d3b2717ff70f2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01262-4https://doaj.org/toc/2041-1723The Mannich reaction proceeds by functionalization of C(sp3)-H bonds alpha to carbonyls. Here, the authors suppress the Mannich reactivity of acetophenones in presence of a manganese catalyst and obtain valuable o-aminoalkylacetophenones and isoindolines via C(sp2)-H functionalization with imines.Bingwei ZhouYuanyuan HuTing LiuCongyang WangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Bingwei Zhou
Yuanyuan Hu
Ting Liu
Congyang Wang
Aromatic C-H addition of ketones to imines enabled by manganese catalysis
description The Mannich reaction proceeds by functionalization of C(sp3)-H bonds alpha to carbonyls. Here, the authors suppress the Mannich reactivity of acetophenones in presence of a manganese catalyst and obtain valuable o-aminoalkylacetophenones and isoindolines via C(sp2)-H functionalization with imines.
format article
author Bingwei Zhou
Yuanyuan Hu
Ting Liu
Congyang Wang
author_facet Bingwei Zhou
Yuanyuan Hu
Ting Liu
Congyang Wang
author_sort Bingwei Zhou
title Aromatic C-H addition of ketones to imines enabled by manganese catalysis
title_short Aromatic C-H addition of ketones to imines enabled by manganese catalysis
title_full Aromatic C-H addition of ketones to imines enabled by manganese catalysis
title_fullStr Aromatic C-H addition of ketones to imines enabled by manganese catalysis
title_full_unstemmed Aromatic C-H addition of ketones to imines enabled by manganese catalysis
title_sort aromatic c-h addition of ketones to imines enabled by manganese catalysis
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/20c2a944a63746be8193d3b2717ff70f
work_keys_str_mv AT bingweizhou aromaticchadditionofketonestoiminesenabledbymanganesecatalysis
AT yuanyuanhu aromaticchadditionofketonestoiminesenabledbymanganesecatalysis
AT tingliu aromaticchadditionofketonestoiminesenabledbymanganesecatalysis
AT congyangwang aromaticchadditionofketonestoiminesenabledbymanganesecatalysis
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