Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations

Nasopharyngeal cancer is frequently characterized by Epstein-Barr virus infection. Here, using genomic analyses, the authors find that the tumours harbour mutations in genes involved in the NF-κB signalling pathway or overexpress a viral oncoprotein, latent membrane protein 1.

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Autores principales:	Yvonne Y Li, Grace T. Y. Chung, Vivian W. Y. Lui, Ka-Fai To, Brigette B. Y. Ma, Chit Chow, John K, S. Woo, Kevin Y. Yip, Jeongsun Seo, Edwin P. Hui, Michael K. F. Mak, Maria Rusan, Nicole G. Chau, Yvonne Y. Y. Or, Marcus H. N. Law, Peggy P. Y. Law, Zoey W. Y. Liu, Hoi-Lam Ngan, Pok-Man Hau, Krista R. Verhoeft, Peony H. Y. Poon, Seong-Keun Yoo, Jong-Yeon Shin, Sau-Dan Lee, Samantha W. M. Lun, Lin Jia, Anthony W. H. Chan, Jason Y. K. Chan, Paul B. S. Lai, Choi-Yi Fung, Suet-Ting Hung, Lin Wang, Ann Margaret V. Chang, Simion I. Chiosea, Matthew L. Hedberg, Sai-Wah Tsao, Andrew C. van Hasselt, Anthony T. C. Chan, Jennifer R. Grandis, Peter S. Hammerman, Kwok-Wai Lo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/20c4453f6c5d4aaa8ca67ab444dfddc0
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spelling	oai:doaj.org-article:20c4453f6c5d4aaa8ca67ab444dfddc02021-12-02T14:40:58ZExome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations10.1038/ncomms141212041-1723https://doaj.org/article/20c4453f6c5d4aaa8ca67ab444dfddc02017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14121https://doaj.org/toc/2041-1723Nasopharyngeal cancer is frequently characterized by Epstein-Barr virus infection. Here, using genomic analyses, the authors find that the tumours harbour mutations in genes involved in the NF-κB signalling pathway or overexpress a viral oncoprotein, latent membrane protein 1.Yvonne Y LiGrace T. Y. ChungVivian W. Y. LuiKa-Fai ToBrigette B. Y. MaChit ChowJohn K, S. WooKevin Y. YipJeongsun SeoEdwin P. HuiMichael K. F. MakMaria RusanNicole G. ChauYvonne Y. Y. OrMarcus H. N. LawPeggy P. Y. LawZoey W. Y. LiuHoi-Lam NganPok-Man HauKrista R. VerhoeftPeony H. Y. PoonSeong-Keun YooJong-Yeon ShinSau-Dan LeeSamantha W. M. LunLin JiaAnthony W. H. ChanJason Y. K. ChanPaul B. S. LaiChoi-Yi FungSuet-Ting HungLin WangAnn Margaret V. ChangSimion I. ChioseaMatthew L. HedbergSai-Wah TsaoAndrew C. van HasseltAnthony T. C. ChanJennifer R. GrandisPeter S. HammermanKwok-Wai LoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yvonne Y Li Grace T. Y. Chung Vivian W. Y. Lui Ka-Fai To Brigette B. Y. Ma Chit Chow John K, S. Woo Kevin Y. Yip Jeongsun Seo Edwin P. Hui Michael K. F. Mak Maria Rusan Nicole G. Chau Yvonne Y. Y. Or Marcus H. N. Law Peggy P. Y. Law Zoey W. Y. Liu Hoi-Lam Ngan Pok-Man Hau Krista R. Verhoeft Peony H. Y. Poon Seong-Keun Yoo Jong-Yeon Shin Sau-Dan Lee Samantha W. M. Lun Lin Jia Anthony W. H. Chan Jason Y. K. Chan Paul B. S. Lai Choi-Yi Fung Suet-Ting Hung Lin Wang Ann Margaret V. Chang Simion I. Chiosea Matthew L. Hedberg Sai-Wah Tsao Andrew C. van Hasselt Anthony T. C. Chan Jennifer R. Grandis Peter S. Hammerman Kwok-Wai Lo Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations
description	Nasopharyngeal cancer is frequently characterized by Epstein-Barr virus infection. Here, using genomic analyses, the authors find that the tumours harbour mutations in genes involved in the NF-κB signalling pathway or overexpress a viral oncoprotein, latent membrane protein 1.
format	article
author	Yvonne Y Li Grace T. Y. Chung Vivian W. Y. Lui Ka-Fai To Brigette B. Y. Ma Chit Chow John K, S. Woo Kevin Y. Yip Jeongsun Seo Edwin P. Hui Michael K. F. Mak Maria Rusan Nicole G. Chau Yvonne Y. Y. Or Marcus H. N. Law Peggy P. Y. Law Zoey W. Y. Liu Hoi-Lam Ngan Pok-Man Hau Krista R. Verhoeft Peony H. Y. Poon Seong-Keun Yoo Jong-Yeon Shin Sau-Dan Lee Samantha W. M. Lun Lin Jia Anthony W. H. Chan Jason Y. K. Chan Paul B. S. Lai Choi-Yi Fung Suet-Ting Hung Lin Wang Ann Margaret V. Chang Simion I. Chiosea Matthew L. Hedberg Sai-Wah Tsao Andrew C. van Hasselt Anthony T. C. Chan Jennifer R. Grandis Peter S. Hammerman Kwok-Wai Lo
author_facet	Yvonne Y Li Grace T. Y. Chung Vivian W. Y. Lui Ka-Fai To Brigette B. Y. Ma Chit Chow John K, S. Woo Kevin Y. Yip Jeongsun Seo Edwin P. Hui Michael K. F. Mak Maria Rusan Nicole G. Chau Yvonne Y. Y. Or Marcus H. N. Law Peggy P. Y. Law Zoey W. Y. Liu Hoi-Lam Ngan Pok-Man Hau Krista R. Verhoeft Peony H. Y. Poon Seong-Keun Yoo Jong-Yeon Shin Sau-Dan Lee Samantha W. M. Lun Lin Jia Anthony W. H. Chan Jason Y. K. Chan Paul B. S. Lai Choi-Yi Fung Suet-Ting Hung Lin Wang Ann Margaret V. Chang Simion I. Chiosea Matthew L. Hedberg Sai-Wah Tsao Andrew C. van Hasselt Anthony T. C. Chan Jennifer R. Grandis Peter S. Hammerman Kwok-Wai Lo
author_sort	Yvonne Y Li
title	Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations
title_short	Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations
title_full	Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations
title_fullStr	Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations
title_full_unstemmed	Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations
title_sort	exome and genome sequencing of nasopharynx cancer identifies nf-κb pathway activating mutations
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/20c4453f6c5d4aaa8ca67ab444dfddc0
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Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations

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