Current Insights: The Impact of Gut Microbiota on Postoperative Complications in Visceral Surgery—A Narrative Review

Postoperative complications are a major problem occurring in up to 50% of patients undergoing major abdominal surgery. Occurrence of postoperative complications is associated with a significantly higher morbidity and mortality in affected patients. The most common postoperative complications are cau...

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Autores principales:	Ann-Kathrin Lederer, Sophia Chikhladze, Eva Kohnert, Roman Huber, Alexander Müller
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	postoperative complications outcome gut microbiome anastomotic leakage surgical site infections ileus Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/20c68a32ed37410986779a3e0ca8173b
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spelling	oai:doaj.org-article:20c68a32ed37410986779a3e0ca8173b2021-11-25T17:21:37ZCurrent Insights: The Impact of Gut Microbiota on Postoperative Complications in Visceral Surgery—A Narrative Review10.3390/diagnostics111120992075-4418https://doaj.org/article/20c68a32ed37410986779a3e0ca8173b2021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/2099https://doaj.org/toc/2075-4418Postoperative complications are a major problem occurring in up to 50% of patients undergoing major abdominal surgery. Occurrence of postoperative complications is associated with a significantly higher morbidity and mortality in affected patients. The most common postoperative complications are caused by an infectious genesis and include anastomotic leakage in case of gastrointestinal anastomosis and surgical site infections. Recent research highlighted the importance of gut microbiota in health and disease. It is plausible that the gut microbiota also plays a pivotal role in the development of postoperative complications. This narrative review critically summarizes results of recent research in this particular field. The review evaluates the role of gut microbiota alteration in postoperative complications, including postoperative ileus, anastomotic leakage, and surgical site infections in visceral surgery. We tried to put a special focus on a potential diagnostic value of pre- and post-operative gut microbiota sampling showing that recent data are inhomogeneous to identify a high-risk microbial profile for development of postoperative complications.Ann-Kathrin LedererSophia ChikhladzeEva KohnertRoman HuberAlexander MüllerMDPI AGarticlepostoperative complicationsoutcomegut microbiomeanastomotic leakagesurgical site infectionsileusMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 2099, p 2099 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	postoperative complications outcome gut microbiome anastomotic leakage surgical site infections ileus Medicine (General) R5-920
spellingShingle	postoperative complications outcome gut microbiome anastomotic leakage surgical site infections ileus Medicine (General) R5-920 Ann-Kathrin Lederer Sophia Chikhladze Eva Kohnert Roman Huber Alexander Müller Current Insights: The Impact of Gut Microbiota on Postoperative Complications in Visceral Surgery—A Narrative Review
description	Postoperative complications are a major problem occurring in up to 50% of patients undergoing major abdominal surgery. Occurrence of postoperative complications is associated with a significantly higher morbidity and mortality in affected patients. The most common postoperative complications are caused by an infectious genesis and include anastomotic leakage in case of gastrointestinal anastomosis and surgical site infections. Recent research highlighted the importance of gut microbiota in health and disease. It is plausible that the gut microbiota also plays a pivotal role in the development of postoperative complications. This narrative review critically summarizes results of recent research in this particular field. The review evaluates the role of gut microbiota alteration in postoperative complications, including postoperative ileus, anastomotic leakage, and surgical site infections in visceral surgery. We tried to put a special focus on a potential diagnostic value of pre- and post-operative gut microbiota sampling showing that recent data are inhomogeneous to identify a high-risk microbial profile for development of postoperative complications.
format	article
author	Ann-Kathrin Lederer Sophia Chikhladze Eva Kohnert Roman Huber Alexander Müller
author_facet	Ann-Kathrin Lederer Sophia Chikhladze Eva Kohnert Roman Huber Alexander Müller
author_sort	Ann-Kathrin Lederer
title	Current Insights: The Impact of Gut Microbiota on Postoperative Complications in Visceral Surgery—A Narrative Review
title_short	Current Insights: The Impact of Gut Microbiota on Postoperative Complications in Visceral Surgery—A Narrative Review
title_full	Current Insights: The Impact of Gut Microbiota on Postoperative Complications in Visceral Surgery—A Narrative Review
title_fullStr	Current Insights: The Impact of Gut Microbiota on Postoperative Complications in Visceral Surgery—A Narrative Review
title_full_unstemmed	Current Insights: The Impact of Gut Microbiota on Postoperative Complications in Visceral Surgery—A Narrative Review
title_sort	current insights: the impact of gut microbiota on postoperative complications in visceral surgery—a narrative review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/20c68a32ed37410986779a3e0ca8173b
work_keys_str_mv	AT annkathrinlederer currentinsightstheimpactofgutmicrobiotaonpostoperativecomplicationsinvisceralsurgeryanarrativereview AT sophiachikhladze currentinsightstheimpactofgutmicrobiotaonpostoperativecomplicationsinvisceralsurgeryanarrativereview AT evakohnert currentinsightstheimpactofgutmicrobiotaonpostoperativecomplicationsinvisceralsurgeryanarrativereview AT romanhuber currentinsightstheimpactofgutmicrobiotaonpostoperativecomplicationsinvisceralsurgeryanarrativereview AT alexandermuller currentinsightstheimpactofgutmicrobiotaonpostoperativecomplicationsinvisceralsurgeryanarrativereview
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Current Insights: The Impact of Gut Microbiota on Postoperative Complications in Visceral Surgery—A Narrative Review

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