25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome

The mechanism underlying neuroinflammation in X-linked adrenoleukodystrophy (ALD) is poorly understood. Here authors identify aberrant production of 25-hydroxycholesterol (25-HC) in ALD patient-derived cells, and show that 25-HC mediates neuroinflammation via activating the NLRP3 inflammasome.

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Autores principales:	Jiho Jang, Sangjun Park, Hye Jin Hur, Hyun-Ju Cho, Inhwa Hwang, Yun Pyo Kang, Isak Im, Hyunji Lee, Eunju Lee, Wonsuk Yang, Hoon-Chul Kang, Sung Won Kwon, Je-Wook Yu, Dong-Wook Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/20c6b5bb71f44d98aad419a4cf590e6d
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spelling	oai:doaj.org-article:20c6b5bb71f44d98aad419a4cf590e6d2021-12-02T17:32:06Z25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome10.1038/ncomms131292041-1723https://doaj.org/article/20c6b5bb71f44d98aad419a4cf590e6d2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13129https://doaj.org/toc/2041-1723The mechanism underlying neuroinflammation in X-linked adrenoleukodystrophy (ALD) is poorly understood. Here authors identify aberrant production of 25-hydroxycholesterol (25-HC) in ALD patient-derived cells, and show that 25-HC mediates neuroinflammation via activating the NLRP3 inflammasome.Jiho JangSangjun ParkHye Jin HurHyun-Ju ChoInhwa HwangYun Pyo KangIsak ImHyunji LeeEunju LeeWonsuk YangHoon-Chul KangSung Won KwonJe-Wook YuDong-Wook KimNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jiho Jang Sangjun Park Hye Jin Hur Hyun-Ju Cho Inhwa Hwang Yun Pyo Kang Isak Im Hyunji Lee Eunju Lee Wonsuk Yang Hoon-Chul Kang Sung Won Kwon Je-Wook Yu Dong-Wook Kim 25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome
description	The mechanism underlying neuroinflammation in X-linked adrenoleukodystrophy (ALD) is poorly understood. Here authors identify aberrant production of 25-hydroxycholesterol (25-HC) in ALD patient-derived cells, and show that 25-HC mediates neuroinflammation via activating the NLRP3 inflammasome.
format	article
author	Jiho Jang Sangjun Park Hye Jin Hur Hyun-Ju Cho Inhwa Hwang Yun Pyo Kang Isak Im Hyunji Lee Eunju Lee Wonsuk Yang Hoon-Chul Kang Sung Won Kwon Je-Wook Yu Dong-Wook Kim
author_facet	Jiho Jang Sangjun Park Hye Jin Hur Hyun-Ju Cho Inhwa Hwang Yun Pyo Kang Isak Im Hyunji Lee Eunju Lee Wonsuk Yang Hoon-Chul Kang Sung Won Kwon Je-Wook Yu Dong-Wook Kim
author_sort	Jiho Jang
title	25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome
title_short	25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome
title_full	25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome
title_fullStr	25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome
title_full_unstemmed	25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome
title_sort	25-hydroxycholesterol contributes to cerebral inflammation of x-linked adrenoleukodystrophy through activation of the nlrp3 inflammasome
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/20c6b5bb71f44d98aad419a4cf590e6d
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25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome

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