Estimation of viral kinetics model parameters in young and aged SARS-CoV-2 infected macaques

The SARS-CoV-2 virus disproportionately causes serious illness and death in older individuals. In order to have the greatest impact in decreasing the human toll caused by the virus, antiviral treatment should be targeted to older patients. For this, we need a better understanding of the differences...

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Autores principales:	Thalia Rodriguez, Hana M. Dobrovolny
Formato:	article
Lenguaje:	EN
Publicado:	The Royal Society 2021
Materias:	COVID-19 SARS-CoV-2 ageing parameter estimation mathematical model Science Q
Acceso en línea:	https://doaj.org/article/20c7dc48ce8b420aaa775f6742076300
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spelling	oai:doaj.org-article:20c7dc48ce8b420aaa775f67420763002021-11-17T08:05:52ZEstimation of viral kinetics model parameters in young and aged SARS-CoV-2 infected macaques10.1098/rsos.2023452054-5703https://doaj.org/article/20c7dc48ce8b420aaa775f67420763002021-11-01T00:00:00Zhttps://royalsocietypublishing.org/doi/10.1098/rsos.202345https://doaj.org/toc/2054-5703The SARS-CoV-2 virus disproportionately causes serious illness and death in older individuals. In order to have the greatest impact in decreasing the human toll caused by the virus, antiviral treatment should be targeted to older patients. For this, we need a better understanding of the differences in viral dynamics between SARS-CoV-2 infection in younger and older adults. In this study, we use previously published averaged viral titre measurements from the nose and throat of SARS-CoV-2 infection in young and aged cynomolgus macaques to parametrize a viral kinetics model. We find that all viral kinetics parameters differ between young and aged macaques in the nasal passages, but that there are fewer differences in parameter estimates from the throat. We further use our parametrized model to study the antiviral treatment of young and aged animals, finding that early antiviral treatment is more likely to lead to a lengthening of the infection in aged animals, but not in young animals.Thalia RodriguezHana M. DobrovolnyThe Royal SocietyarticleCOVID-19SARS-CoV-2ageingparameter estimationmathematical modelScienceQENRoyal Society Open Science, Vol 8, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 SARS-CoV-2 ageing parameter estimation mathematical model Science Q
spellingShingle	COVID-19 SARS-CoV-2 ageing parameter estimation mathematical model Science Q Thalia Rodriguez Hana M. Dobrovolny Estimation of viral kinetics model parameters in young and aged SARS-CoV-2 infected macaques
description	The SARS-CoV-2 virus disproportionately causes serious illness and death in older individuals. In order to have the greatest impact in decreasing the human toll caused by the virus, antiviral treatment should be targeted to older patients. For this, we need a better understanding of the differences in viral dynamics between SARS-CoV-2 infection in younger and older adults. In this study, we use previously published averaged viral titre measurements from the nose and throat of SARS-CoV-2 infection in young and aged cynomolgus macaques to parametrize a viral kinetics model. We find that all viral kinetics parameters differ between young and aged macaques in the nasal passages, but that there are fewer differences in parameter estimates from the throat. We further use our parametrized model to study the antiviral treatment of young and aged animals, finding that early antiviral treatment is more likely to lead to a lengthening of the infection in aged animals, but not in young animals.
format	article
author	Thalia Rodriguez Hana M. Dobrovolny
author_facet	Thalia Rodriguez Hana M. Dobrovolny
author_sort	Thalia Rodriguez
title	Estimation of viral kinetics model parameters in young and aged SARS-CoV-2 infected macaques
title_short	Estimation of viral kinetics model parameters in young and aged SARS-CoV-2 infected macaques
title_full	Estimation of viral kinetics model parameters in young and aged SARS-CoV-2 infected macaques
title_fullStr	Estimation of viral kinetics model parameters in young and aged SARS-CoV-2 infected macaques
title_full_unstemmed	Estimation of viral kinetics model parameters in young and aged SARS-CoV-2 infected macaques
title_sort	estimation of viral kinetics model parameters in young and aged sars-cov-2 infected macaques
publisher	The Royal Society
publishDate	2021
url	https://doaj.org/article/20c7dc48ce8b420aaa775f6742076300
work_keys_str_mv	AT thaliarodriguez estimationofviralkineticsmodelparametersinyoungandagedsarscov2infectedmacaques AT hanamdobrovolny estimationofviralkineticsmodelparametersinyoungandagedsarscov2infectedmacaques
_version_	1718425786491338752

Estimation of viral kinetics model parameters in young and aged SARS-CoV-2 infected macaques

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