Eco-friendly ultraviolet spectrophotometric methods for the determination of clotrimazole and tinidazole in bulk and ointment dosage form

Analyzing a drug over its overlapped spectra utilizes sophisticated instruments and more toxic solvents, which has a deleterious effect on environmental safety. There is an alarming need to develop a simple, novel, and cost-effective method for determining combined substances that are non-t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kanaka Parvathi Kannaiah, Abimanyu Sugumaran
Formato:	article
Lenguaje:	EN
Publicado:	Growing Science 2022
Materias:	Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/20c96f3d9ae64c77a74412218414ed8f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:20c96f3d9ae64c77a74412218414ed8f
record_format	dspace
spelling	oai:doaj.org-article:20c96f3d9ae64c77a74412218414ed8f2021-11-12T12:52:42ZEco-friendly ultraviolet spectrophotometric methods for the determination of clotrimazole and tinidazole in bulk and ointment dosage form1927-72961927-730X10.5267/j.ccl.2021.11.001https://doaj.org/article/20c96f3d9ae64c77a74412218414ed8f2022-01-01T00:00:00Zhttp://www.growingscience.com/ccl/Vol11/ccl_2021_40.pdfhttps://doaj.org/toc/1927-7296https://doaj.org/toc/1927-730X Analyzing a drug over its overlapped spectra utilizes sophisticated instruments and more toxic solvents, which has a deleterious effect on environmental safety. There is an alarming need to develop a simple, novel, and cost-effective method for determining combined substances that are non-toxic to the environment. So, the study aimed to develop four simple, fast and eco-friendly spectrophotometric techniques for quantifying clotrimazole and tinidazole in bulk and ointment dosage form. Stock solutions produced at concentrations of 7 to 13 and 17.5 to 32.5 µg/mL of clotrimazole and tinidazole in 10% v/v ethanol and scanned in the UV-visible range 200-450 nm, and used for all methods. The methods were validated according to the International Council for Harmonization guidelines and found to be within limits. Additionally, the outliers were tested by using the Grubbers test and found within limits. Finally, green evaluation studies show that the method is more environmentally friendly, as confirmed by four assessment tools.Kanaka Parvathi KannaiahAbimanyu SugumaranGrowing SciencearticleChemistryQD1-999ENCurrent Chemistry Letters, Vol 11, Iss 1, Pp 11-22 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chemistry QD1-999
spellingShingle	Chemistry QD1-999 Kanaka Parvathi Kannaiah Abimanyu Sugumaran Eco-friendly ultraviolet spectrophotometric methods for the determination of clotrimazole and tinidazole in bulk and ointment dosage form
description	Analyzing a drug over its overlapped spectra utilizes sophisticated instruments and more toxic solvents, which has a deleterious effect on environmental safety. There is an alarming need to develop a simple, novel, and cost-effective method for determining combined substances that are non-toxic to the environment. So, the study aimed to develop four simple, fast and eco-friendly spectrophotometric techniques for quantifying clotrimazole and tinidazole in bulk and ointment dosage form. Stock solutions produced at concentrations of 7 to 13 and 17.5 to 32.5 µg/mL of clotrimazole and tinidazole in 10% v/v ethanol and scanned in the UV-visible range 200-450 nm, and used for all methods. The methods were validated according to the International Council for Harmonization guidelines and found to be within limits. Additionally, the outliers were tested by using the Grubbers test and found within limits. Finally, green evaluation studies show that the method is more environmentally friendly, as confirmed by four assessment tools.
format	article
author	Kanaka Parvathi Kannaiah Abimanyu Sugumaran
author_facet	Kanaka Parvathi Kannaiah Abimanyu Sugumaran
author_sort	Kanaka Parvathi Kannaiah
title	Eco-friendly ultraviolet spectrophotometric methods for the determination of clotrimazole and tinidazole in bulk and ointment dosage form
title_short	Eco-friendly ultraviolet spectrophotometric methods for the determination of clotrimazole and tinidazole in bulk and ointment dosage form
title_full	Eco-friendly ultraviolet spectrophotometric methods for the determination of clotrimazole and tinidazole in bulk and ointment dosage form
title_fullStr	Eco-friendly ultraviolet spectrophotometric methods for the determination of clotrimazole and tinidazole in bulk and ointment dosage form
title_full_unstemmed	Eco-friendly ultraviolet spectrophotometric methods for the determination of clotrimazole and tinidazole in bulk and ointment dosage form
title_sort	eco-friendly ultraviolet spectrophotometric methods for the determination of clotrimazole and tinidazole in bulk and ointment dosage form
publisher	Growing Science
publishDate	2022
url	https://doaj.org/article/20c96f3d9ae64c77a74412218414ed8f
work_keys_str_mv	AT kanakaparvathikannaiah ecofriendlyultravioletspectrophotometricmethodsforthedeterminationofclotrimazoleandtinidazoleinbulkandointmentdosageform AT abimanyusugumaran ecofriendlyultravioletspectrophotometricmethodsforthedeterminationofclotrimazoleandtinidazoleinbulkandointmentdosageform
_version_	1718430483655688192

Eco-friendly ultraviolet spectrophotometric methods for the determination of clotrimazole and tinidazole in bulk and ointment dosage form

Ejemplares similares