Cancer Stem Cells in Tumor Modeling: Challenges and Future Directions

Microfluidic tumors‐on‐chips models have revolutionized anticancer therapeutic research by creating an ideal microenvironment for cancer cells. The tumor microenvironment (TME) includes various cell types and cancer stem cells (CSCs), which are postulated to regulate the growth, invasion, and migrat...

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Autores principales:	Elvan Dogan, Asli Kisim, Gizem Bati-Ayaz, Gregory J. Kubicek, Devrim Pesen-Okvur, Amir K. Miri
Formato:	article
Lenguaje:	EN
Publicado:	Wiley-VCH 2021
Materias:	cancer stem cells microfluidics tumor microenvironments tumors-on-chips Biotechnology TP248.13-248.65 Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/20cc3cc5a5d74347be93fa6f7ce17f70
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id	oai:doaj.org-article:20cc3cc5a5d74347be93fa6f7ce17f70
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spelling	oai:doaj.org-article:20cc3cc5a5d74347be93fa6f7ce17f702021-11-06T04:12:26ZCancer Stem Cells in Tumor Modeling: Challenges and Future Directions2699-930710.1002/anbr.202100017https://doaj.org/article/20cc3cc5a5d74347be93fa6f7ce17f702021-11-01T00:00:00Zhttps://doi.org/10.1002/anbr.202100017https://doaj.org/toc/2699-9307Microfluidic tumors‐on‐chips models have revolutionized anticancer therapeutic research by creating an ideal microenvironment for cancer cells. The tumor microenvironment (TME) includes various cell types and cancer stem cells (CSCs), which are postulated to regulate the growth, invasion, and migratory behavior of tumor cells. In this review, the biological niches of the TME and cancer cell behavior focusing on the behavior of CSCs are summarized. Conventional cancer models such as 3D cultures and organoid models are reviewed. Opportunities for the incorporation of CSCs with tumors‐on‐chips are then discussed for creating tumor invasion models. Such models will represent a paradigm shift in the cancer community by allowing oncologists and clinicians to predict better which cancer patients will benefit from chemotherapy treatments.Elvan DoganAsli KisimGizem Bati-AyazGregory J. KubicekDevrim Pesen-OkvurAmir K. MiriWiley-VCHarticlecancer stem cellsmicrofluidicstumor microenvironmentstumors-on-chipsBiotechnologyTP248.13-248.65Medical technologyR855-855.5ENAdvanced NanoBiomed Research, Vol 1, Iss 11, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cancer stem cells microfluidics tumor microenvironments tumors-on-chips Biotechnology TP248.13-248.65 Medical technology R855-855.5
spellingShingle	cancer stem cells microfluidics tumor microenvironments tumors-on-chips Biotechnology TP248.13-248.65 Medical technology R855-855.5 Elvan Dogan Asli Kisim Gizem Bati-Ayaz Gregory J. Kubicek Devrim Pesen-Okvur Amir K. Miri Cancer Stem Cells in Tumor Modeling: Challenges and Future Directions
description	Microfluidic tumors‐on‐chips models have revolutionized anticancer therapeutic research by creating an ideal microenvironment for cancer cells. The tumor microenvironment (TME) includes various cell types and cancer stem cells (CSCs), which are postulated to regulate the growth, invasion, and migratory behavior of tumor cells. In this review, the biological niches of the TME and cancer cell behavior focusing on the behavior of CSCs are summarized. Conventional cancer models such as 3D cultures and organoid models are reviewed. Opportunities for the incorporation of CSCs with tumors‐on‐chips are then discussed for creating tumor invasion models. Such models will represent a paradigm shift in the cancer community by allowing oncologists and clinicians to predict better which cancer patients will benefit from chemotherapy treatments.
format	article
author	Elvan Dogan Asli Kisim Gizem Bati-Ayaz Gregory J. Kubicek Devrim Pesen-Okvur Amir K. Miri
author_facet	Elvan Dogan Asli Kisim Gizem Bati-Ayaz Gregory J. Kubicek Devrim Pesen-Okvur Amir K. Miri
author_sort	Elvan Dogan
title	Cancer Stem Cells in Tumor Modeling: Challenges and Future Directions
title_short	Cancer Stem Cells in Tumor Modeling: Challenges and Future Directions
title_full	Cancer Stem Cells in Tumor Modeling: Challenges and Future Directions
title_fullStr	Cancer Stem Cells in Tumor Modeling: Challenges and Future Directions
title_full_unstemmed	Cancer Stem Cells in Tumor Modeling: Challenges and Future Directions
title_sort	cancer stem cells in tumor modeling: challenges and future directions
publisher	Wiley-VCH
publishDate	2021
url	https://doaj.org/article/20cc3cc5a5d74347be93fa6f7ce17f70
work_keys_str_mv	AT elvandogan cancerstemcellsintumormodelingchallengesandfuturedirections AT aslikisim cancerstemcellsintumormodelingchallengesandfuturedirections AT gizembatiayaz cancerstemcellsintumormodelingchallengesandfuturedirections AT gregoryjkubicek cancerstemcellsintumormodelingchallengesandfuturedirections AT devrimpesenokvur cancerstemcellsintumormodelingchallengesandfuturedirections AT amirkmiri cancerstemcellsintumormodelingchallengesandfuturedirections
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Cancer Stem Cells in Tumor Modeling: Challenges and Future Directions

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