Enhanced protective immunity against SARS-CoV-2 elicited by a VSV vector expressing a chimeric spike protein

Enhanced protective immunity against SARS-CoV-2 elicited by a VSV vector expressing a chimeric spike protein

Abstract SARS-CoV-2 and SARS-CoV are genetically related coronavirus and share the same cellular receptor ACE2. By replacing the VSV glycoprotein with the spikes (S) of SARS-CoV-2 and SARS-CoV, we generated two replication-competent recombinant viruses, rVSV-SARS-CoV-2 and rVSV-SARS-CoV. Using wild-...

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Autores principales: Hongyue Li, Yuhang Zhang, Dong Li, Yong-Qiang Deng, Hongde Xu, Chaoyue Zhao, Jiandong Liu, Dan Wen, Jianguo Zhao, Yongchun Li, Yong Wu, Shujun Liu, Jiankai Liu, Junfeng Hao, Fei Yuan, Shuguang Duo, Cheng-Feng Qin, Aihua Zheng
Formato: article
Lenguaje:EN
Publicado: Nature Publishing Group 2021
Materias:
Medicine
R
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/20ce20681e0349298e8a21ba9531574e
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