MCR-1 Inhibition with Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Restores Sensitivity to Polymyxin in <italic toggle="yes">Escherichia coli</italic>

ABSTRACT In late 2015, the first example of a transferrable polymyxin resistance mechanism in Gram-negative pathogens, MCR-1, was reported. Since that report, MCR-1 has been described to occur in many Gram-negative pathogens, and the mechanism of MCR-1-mediated resistance was rapidly determined: an...

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Bibliographic Details
Main Authors: Seth M. Daly, Carolyn R. Sturge, Christina F. Felder-Scott, Bruce L. Geller, David E. Greenberg
Format: article
Language:EN
Published: American Society for Microbiology 2017
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Online Access:https://doaj.org/article/20cf5819086a40f8a7c1f2218e24f8d5
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