Impaired bone healing in multitrauma patients is associated with altered leukocyte kinetics after major trauma

Okan W Bastian,1 Anne Kuijer,1 Leo Koenderman,2 Rebecca K Stellato,3 Wouter W van Solinge,4 Luke PH Leenen,1 Taco J Blokhuis1 1Department of Traumatology, 2Department of Respiratory Medicine, 3Department of Biostatistics and Research Support, Julius Center, 4Department of Clinical Chemistry and Hema...

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Autores principales:	Bastian OW, Kuijer A, Koenderman L, Stellato RK, van Solinge WW, Leenen LPH, Blokhuis TJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	SIRS inflammation neutrophils myelopoiesis regeneration. Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/20d0d6ea47d54faa865977396fb65ef8
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spelling	oai:doaj.org-article:20d0d6ea47d54faa865977396fb65ef82021-12-02T02:42:54ZImpaired bone healing in multitrauma patients is associated with altered leukocyte kinetics after major trauma1178-7031https://doaj.org/article/20d0d6ea47d54faa865977396fb65ef82016-05-01T00:00:00Zhttps://www.dovepress.com/impaired-bone-healing-in-multitrauma-patients-is-associated-with-alter-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Okan W Bastian,1 Anne Kuijer,1 Leo Koenderman,2 Rebecca K Stellato,3 Wouter W van Solinge,4 Luke PH Leenen,1 Taco J Blokhuis1 1Department of Traumatology, 2Department of Respiratory Medicine, 3Department of Biostatistics and Research Support, Julius Center, 4Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, the Netherlands Abstract: Animal studies have shown that the systemic inflammatory response to major injury impairs bone regeneration. It remains unclear whether the systemic immune response contributes to impairment of fracture healing in multitrauma patients. It is well known that systemic inflammatory changes after major trauma affect leukocyte kinetics. We therefore retrospectively compared the cellular composition of peripheral blood during the first 2 weeks after injury between multitrauma patients with normal (n=48) and impaired (n=32) fracture healing of the tibia. The peripheral blood-count curves of leukocytes, neutrophils, monocytes, and thrombocytes differed significantly between patients with normal and impaired fracture healing during the first 2 weeks after trauma (P-values were 0.0122, 0.0083, 0.0204, and <0.0001, respectively). Mean myeloid cell counts were above reference values during the second week after injury. Our data indicate that leukocyte kinetics differ significantly between patients with normal and impaired fracture healing during the first 2 weeks after major injury. This finding suggests that the systemic immune response to major trauma can disturb tissue regeneration. Keywords: SIRS, inflammation, neutrophils, myelopoiesis, regenerationBastian OWKuijer AKoenderman LStellato RKvan Solinge WWLeenen LPHBlokhuis TJDove Medical PressarticleSIRSinflammationneutrophilsmyelopoiesisregeneration.PathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol 2016, Iss Issue 1, Pp 69-78 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	SIRS inflammation neutrophils myelopoiesis regeneration. Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	SIRS inflammation neutrophils myelopoiesis regeneration. Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Bastian OW Kuijer A Koenderman L Stellato RK van Solinge WW Leenen LPH Blokhuis TJ Impaired bone healing in multitrauma patients is associated with altered leukocyte kinetics after major trauma
description	Okan W Bastian,1 Anne Kuijer,1 Leo Koenderman,2 Rebecca K Stellato,3 Wouter W van Solinge,4 Luke PH Leenen,1 Taco J Blokhuis1 1Department of Traumatology, 2Department of Respiratory Medicine, 3Department of Biostatistics and Research Support, Julius Center, 4Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, the Netherlands Abstract: Animal studies have shown that the systemic inflammatory response to major injury impairs bone regeneration. It remains unclear whether the systemic immune response contributes to impairment of fracture healing in multitrauma patients. It is well known that systemic inflammatory changes after major trauma affect leukocyte kinetics. We therefore retrospectively compared the cellular composition of peripheral blood during the first 2 weeks after injury between multitrauma patients with normal (n=48) and impaired (n=32) fracture healing of the tibia. The peripheral blood-count curves of leukocytes, neutrophils, monocytes, and thrombocytes differed significantly between patients with normal and impaired fracture healing during the first 2 weeks after trauma (P-values were 0.0122, 0.0083, 0.0204, and <0.0001, respectively). Mean myeloid cell counts were above reference values during the second week after injury. Our data indicate that leukocyte kinetics differ significantly between patients with normal and impaired fracture healing during the first 2 weeks after major injury. This finding suggests that the systemic immune response to major trauma can disturb tissue regeneration. Keywords: SIRS, inflammation, neutrophils, myelopoiesis, regeneration
format	article
author	Bastian OW Kuijer A Koenderman L Stellato RK van Solinge WW Leenen LPH Blokhuis TJ
author_facet	Bastian OW Kuijer A Koenderman L Stellato RK van Solinge WW Leenen LPH Blokhuis TJ
author_sort	Bastian OW
title	Impaired bone healing in multitrauma patients is associated with altered leukocyte kinetics after major trauma
title_short	Impaired bone healing in multitrauma patients is associated with altered leukocyte kinetics after major trauma
title_full	Impaired bone healing in multitrauma patients is associated with altered leukocyte kinetics after major trauma
title_fullStr	Impaired bone healing in multitrauma patients is associated with altered leukocyte kinetics after major trauma
title_full_unstemmed	Impaired bone healing in multitrauma patients is associated with altered leukocyte kinetics after major trauma
title_sort	impaired bone healing in multitrauma patients is associated with altered leukocyte kinetics after major trauma
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/20d0d6ea47d54faa865977396fb65ef8
work_keys_str_mv	AT bastianow impairedbonehealinginmultitraumapatientsisassociatedwithalteredleukocytekineticsaftermajortrauma AT kuijera impairedbonehealinginmultitraumapatientsisassociatedwithalteredleukocytekineticsaftermajortrauma AT koendermanl impairedbonehealinginmultitraumapatientsisassociatedwithalteredleukocytekineticsaftermajortrauma AT stellatork impairedbonehealinginmultitraumapatientsisassociatedwithalteredleukocytekineticsaftermajortrauma AT vansolingeww impairedbonehealinginmultitraumapatientsisassociatedwithalteredleukocytekineticsaftermajortrauma AT leenenlph impairedbonehealinginmultitraumapatientsisassociatedwithalteredleukocytekineticsaftermajortrauma AT blokhuistj impairedbonehealinginmultitraumapatientsisassociatedwithalteredleukocytekineticsaftermajortrauma
_version_	1718402206092230656

Impaired bone healing in multitrauma patients is associated with altered leukocyte kinetics after major trauma

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