Human tumour immune evasion via TGF-β blocks NK cell activation but not survival allowing therapeutic restoration of anti-tumour activity.
Immune evasion is now recognized as a key feature of cancer progression. In animal models, the activity of cytotoxic lymphocytes is suppressed in the tumour microenvironment by the immunosuppressive cytokine, Transforming Growth Factor (TGF)-β. Release from TGF-β-mediated inhibition restores anti-tu...
Guardado en:
Autores principales: | Erica B Wilson, Jehan J El-Jawhari, Abbie L Neilson, Geoffrey D Hall, Alan A Melcher, Josephine L Meade, Graham P Cook |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2011
|
Materias: | |
Acceso en línea: | https://doaj.org/article/20d56bb28df2483d9ebfcbba024203d3 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
IL-21-mediated reversal of NK cell exhaustion facilitates anti-tumour immunity in MHC class I-deficient tumours
por: Hyungseok Seo, et al.
Publicado: (2017) -
Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness
por: Alexandra Avgustinova, et al.
Publicado: (2016) -
Circulating tumour DNA from the cerebrospinal fluid allows the characterisation and monitoring of medulloblastoma
por: Laura Escudero, et al.
Publicado: (2020) -
DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load
por: Hyunchul Jung, et al.
Publicado: (2019) -
Whole-organ analysis of TGF-β-mediated remodelling of the tumour microenvironment by tissue clearing
por: Shimpei I. Kubota, et al.
Publicado: (2021)