The Pulsatile Modification Improves Hemodynamics and Attenuates Inflammatory Responses in Extracorporeal Membrane Oxygenation

Guanhua Li,1,2 Jianfeng Zeng,3 Zhaoyuan Liu,4 Yu Zhang,5,* Xiaoping Fan6,* 1Department of Cardiovascular Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, People’s Republic of China; 2Department of Cardiovascular Surgery, Guangdong Cardiovascular Institute,...

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Autores principales:	Li G, Zeng J, Liu Z, Zhang Y, Fan X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	pulsatile flow extracorporeal membrane oxygenation inflammatory response covid-19 Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/20d6f306164f45c998fa2b702cce6827
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id	oai:doaj.org-article:20d6f306164f45c998fa2b702cce6827
record_format	dspace
institution	DOAJ
collection	DOAJ
language	EN
topic	pulsatile flow extracorporeal membrane oxygenation inflammatory response covid-19 Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	pulsatile flow extracorporeal membrane oxygenation inflammatory response covid-19 Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Li G Zeng J Liu Z Zhang Y Fan X The Pulsatile Modification Improves Hemodynamics and Attenuates Inflammatory Responses in Extracorporeal Membrane Oxygenation
description	Guanhua Li,1,2 Jianfeng Zeng,3 Zhaoyuan Liu,4 Yu Zhang,5,* Xiaoping Fan6,* 1Department of Cardiovascular Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, People’s Republic of China; 2Department of Cardiovascular Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, People’s Republic of China; 3Department of Anesthesiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, People’s Republic of China; 4Department of Hepatobiliary Surgery, Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, People’s Republic of China; 5Department of Pathology, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510120, People’s Republic of China; 6Department of Cardiovascular Surgery, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510006, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaoping FanDepartment of Cardiovascular Surgery, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, No. 55, Neihuan Xi Road, Panyu District, Guangzhou, 510006, People’s Republic of ChinaTel/Fax +86 20-81887233Email fukui-hanson@hotmail.comYu ZhangDepartment of Pathology, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, No. 111, Dade Road, Guangzhou, 510120, People’s Republic of ChinaTel/Fax +86 20-81887233Email zyddyf@126.comBackground: COVID-19 is still a worldwide pandemic and extracorporeal membrane oxygenation (ECMO) is vital for extremely critical COVID-19 patients. Pulsatile flow impacts greatly on organ function and microcirculation, however, the effects of pulsatile flow on hemodynamics and inflammatory responses during ECMO are unknown. An in vivo study was launched aiming at comparing the two perfusion modes in ECMO.Methods: Fourteen beagles were randomly allocated into two groups: the pulsatile group (n=7) and the non-pulsatile group (n=7). ECMO was conducted using the i-Cor system for 24 hours. Hemodynamic parameters including surplus hemodynamic energy (SHE), energy equivalent pressure (EEP), oxygenator pressure drop (OPD), and circuit pressure drop (CPD) were monitored. To assess inflammatory responses during ECMO, levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, IL-8, and transforming growth factor-β 1 (TGF-β 1) were measured.Results: EEP and SHE were markedly higher in pulsatile circuits when compared with the conventional circuits. Between-group differences in both OPD and CPD reached statistical significance. Significant decreases in TNF-α were seen in animals treated with pulsatile flows at 2 hours, 12 hours, and 24 hours as well as a decrease in IL-1β at 24 hours during ECMO. The TGF-β 1 levels were significantly higher in pulsatile circuits from 2 hours to 24 hours. The changes in IL-6 and IL-8 levels were insignificant.Conclusion: The modification of pulsatility in ECMO generates more hemodynamic energies and attenuates inflammatory responses as compared to the conventional non-pulsatile ECMO.Keywords: pulsatile flow, extracorporeal membrane oxygenation, inflammatory response, COVID-19
format	article
author	Li G Zeng J Liu Z Zhang Y Fan X
author_facet	Li G Zeng J Liu Z Zhang Y Fan X
author_sort	Li G
title	The Pulsatile Modification Improves Hemodynamics and Attenuates Inflammatory Responses in Extracorporeal Membrane Oxygenation
title_short	The Pulsatile Modification Improves Hemodynamics and Attenuates Inflammatory Responses in Extracorporeal Membrane Oxygenation
title_full	The Pulsatile Modification Improves Hemodynamics and Attenuates Inflammatory Responses in Extracorporeal Membrane Oxygenation
title_fullStr	The Pulsatile Modification Improves Hemodynamics and Attenuates Inflammatory Responses in Extracorporeal Membrane Oxygenation
title_full_unstemmed	The Pulsatile Modification Improves Hemodynamics and Attenuates Inflammatory Responses in Extracorporeal Membrane Oxygenation
title_sort	pulsatile modification improves hemodynamics and attenuates inflammatory responses in extracorporeal membrane oxygenation
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/20d6f306164f45c998fa2b702cce6827
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spelling	oai:doaj.org-article:20d6f306164f45c998fa2b702cce68272021-12-02T14:38:05ZThe Pulsatile Modification Improves Hemodynamics and Attenuates Inflammatory Responses in Extracorporeal Membrane Oxygenation1178-7031https://doaj.org/article/20d6f306164f45c998fa2b702cce68272021-04-01T00:00:00Zhttps://www.dovepress.com/the-pulsatile-modification-improves-hemodynamics-and-attenuates-inflam-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Guanhua Li,1,2 Jianfeng Zeng,3 Zhaoyuan Liu,4 Yu Zhang,5,* Xiaoping Fan6,* 1Department of Cardiovascular Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, People’s Republic of China; 2Department of Cardiovascular Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, People’s Republic of China; 3Department of Anesthesiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, People’s Republic of China; 4Department of Hepatobiliary Surgery, Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, People’s Republic of China; 5Department of Pathology, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510120, People’s Republic of China; 6Department of Cardiovascular Surgery, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510006, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaoping FanDepartment of Cardiovascular Surgery, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, No. 55, Neihuan Xi Road, Panyu District, Guangzhou, 510006, People’s Republic of ChinaTel/Fax +86 20-81887233Email fukui-hanson@hotmail.comYu ZhangDepartment of Pathology, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, No. 111, Dade Road, Guangzhou, 510120, People’s Republic of ChinaTel/Fax +86 20-81887233Email zyddyf@126.comBackground: COVID-19 is still a worldwide pandemic and extracorporeal membrane oxygenation (ECMO) is vital for extremely critical COVID-19 patients. Pulsatile flow impacts greatly on organ function and microcirculation, however, the effects of pulsatile flow on hemodynamics and inflammatory responses during ECMO are unknown. An in vivo study was launched aiming at comparing the two perfusion modes in ECMO.Methods: Fourteen beagles were randomly allocated into two groups: the pulsatile group (n=7) and the non-pulsatile group (n=7). ECMO was conducted using the i-Cor system for 24 hours. Hemodynamic parameters including surplus hemodynamic energy (SHE), energy equivalent pressure (EEP), oxygenator pressure drop (OPD), and circuit pressure drop (CPD) were monitored. To assess inflammatory responses during ECMO, levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, IL-8, and transforming growth factor-β 1 (TGF-β 1) were measured.Results: EEP and SHE were markedly higher in pulsatile circuits when compared with the conventional circuits. Between-group differences in both OPD and CPD reached statistical significance. Significant decreases in TNF-α were seen in animals treated with pulsatile flows at 2 hours, 12 hours, and 24 hours as well as a decrease in IL-1β at 24 hours during ECMO. The TGF-β 1 levels were significantly higher in pulsatile circuits from 2 hours to 24 hours. The changes in IL-6 and IL-8 levels were insignificant.Conclusion: The modification of pulsatility in ECMO generates more hemodynamic energies and attenuates inflammatory responses as compared to the conventional non-pulsatile ECMO.Keywords: pulsatile flow, extracorporeal membrane oxygenation, inflammatory response, COVID-19Li GZeng JLiu ZZhang YFan XDove Medical Pressarticlepulsatile flowextracorporeal membrane oxygenationinflammatory responsecovid-19PathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 1357-1364 (2021)

The Pulsatile Modification Improves Hemodynamics and Attenuates Inflammatory Responses in Extracorporeal Membrane Oxygenation

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