Effects of treadmill running with different intensity on rat subchondral bone

Abstract Subchondral bone (SB) is recognized as a key factor in normal joint protection, not only does it provide a shock absorbing and supportive function for the cartilage, but it may also be important for cartilage metabolism. Mechanical loading is considered to be a critical regulator of skeleta...

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Autores principales:	Zhe Li, Sheng-Yao Liu, Lei Xu, Shao-Yong Xu, Guo-Xin Ni
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/20da57da062a4b3cae24a52f897dbb55
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spelling	oai:doaj.org-article:20da57da062a4b3cae24a52f897dbb552021-12-02T11:40:22ZEffects of treadmill running with different intensity on rat subchondral bone10.1038/s41598-017-02126-z2045-2322https://doaj.org/article/20da57da062a4b3cae24a52f897dbb552017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02126-zhttps://doaj.org/toc/2045-2322Abstract Subchondral bone (SB) is recognized as a key factor in normal joint protection, not only does it provide a shock absorbing and supportive function for the cartilage, but it may also be important for cartilage metabolism. Mechanical loading is considered to be a critical regulator of skeletal homeostasis, including bone and cartilage. It is suggested that both cartilage and bone may respond to mechanical loading in an intensity-dependent manner. In this report, we have discovered that the subchondral plate became thicker with higher bone mineral density (BMD) and lower porosity, while trabecular bone became more plate-like and denser with higher BMD in high-intensity running (HIR) group. Further, HIR led to highly remodeled, less mineralized, and stiffer subchondral plate and trabecular bone. On the contrary, low-intensity running and moderate-intensity running failed to result in considerable changes in microstructure, composition and hardness. Our findings suggested that running affects SB in an intensity-dependent manner. In addition, HIR may induce change in organization and composition of SB, and consequently alter its mechanical properties. HIR-induced “brittle and stiff” SB may adversely affect the overlying articular cartilage.Zhe LiSheng-Yao LiuLei XuShao-Yong XuGuo-Xin NiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhe Li Sheng-Yao Liu Lei Xu Shao-Yong Xu Guo-Xin Ni Effects of treadmill running with different intensity on rat subchondral bone
description	Abstract Subchondral bone (SB) is recognized as a key factor in normal joint protection, not only does it provide a shock absorbing and supportive function for the cartilage, but it may also be important for cartilage metabolism. Mechanical loading is considered to be a critical regulator of skeletal homeostasis, including bone and cartilage. It is suggested that both cartilage and bone may respond to mechanical loading in an intensity-dependent manner. In this report, we have discovered that the subchondral plate became thicker with higher bone mineral density (BMD) and lower porosity, while trabecular bone became more plate-like and denser with higher BMD in high-intensity running (HIR) group. Further, HIR led to highly remodeled, less mineralized, and stiffer subchondral plate and trabecular bone. On the contrary, low-intensity running and moderate-intensity running failed to result in considerable changes in microstructure, composition and hardness. Our findings suggested that running affects SB in an intensity-dependent manner. In addition, HIR may induce change in organization and composition of SB, and consequently alter its mechanical properties. HIR-induced “brittle and stiff” SB may adversely affect the overlying articular cartilage.
format	article
author	Zhe Li Sheng-Yao Liu Lei Xu Shao-Yong Xu Guo-Xin Ni
author_facet	Zhe Li Sheng-Yao Liu Lei Xu Shao-Yong Xu Guo-Xin Ni
author_sort	Zhe Li
title	Effects of treadmill running with different intensity on rat subchondral bone
title_short	Effects of treadmill running with different intensity on rat subchondral bone
title_full	Effects of treadmill running with different intensity on rat subchondral bone
title_fullStr	Effects of treadmill running with different intensity on rat subchondral bone
title_full_unstemmed	Effects of treadmill running with different intensity on rat subchondral bone
title_sort	effects of treadmill running with different intensity on rat subchondral bone
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/20da57da062a4b3cae24a52f897dbb55
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_version_	1718395629464453120

Effects of treadmill running with different intensity on rat subchondral bone

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