UPSHOTS IN ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA: ANALYSIS OF T-CELL BRAZIL PROJECT
Objective: T-cell Brazil Project was designed as an ambispective data collection from January 2015 to December 2022 of previously untreated patients diagnosed with Peripheral T-cell lymphoma (PTCL) or NK/T-cell lymphoma according to the revised WHO 2017 classification in Brazil. The primary and seco...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Elsevier
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/20dc4648a67f400fa1a4587d8fa08899 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:20dc4648a67f400fa1a4587d8fa08899 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:20dc4648a67f400fa1a4587d8fa088992021-11-10T04:32:33ZUPSHOTS IN ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA: ANALYSIS OF T-CELL BRAZIL PROJECT2531-137910.1016/j.htct.2021.10.972https://doaj.org/article/20dc4648a67f400fa1a4587d8fa088992021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2531137921011196https://doaj.org/toc/2531-1379Objective: T-cell Brazil Project was designed as an ambispective data collection from January 2015 to December 2022 of previously untreated patients diagnosed with Peripheral T-cell lymphoma (PTCL) or NK/T-cell lymphoma according to the revised WHO 2017 classification in Brazil. The primary and secondary end points were 2-year overall survival (OS) and progression-free survival (PFS). Clinical, treatment and survival data were also correlated. Methodology: Twenty centers got approved for the study from the local and national institutional review board and registered their cases only online. OS was calculated from diagnosis date until last seen or death date, whereas PFS until first event, progression / relapse, date of death or last seen. Kaplan-Meier method was applied and a Log-rank test to compare their curves. P-value less than 5% was considered. From a total of 416 patients with PTCL, 46 (11%) were diagnosed as AITL. Results: The median age was 65 years (31-82), with 63% males, 94% had advanced-stage disease. All patients received 61% CHOEP, 28% CHOP and 11% CT without anthracycline. 20% of pts were consolidated with autologous transplant (HSCT). There were 19 (41%) deaths, 10 by lymphoma, 8 infections, 1 new neoplasia. With 8-mo median f/u (1-36), OS at 24-mo was 27% and 2-year PFS was 21%. As consolidation, OS was 71% HSCT group vs. 16% no HSCT (P= 0.06) and PFS was 71% vs. 8%, respectively (P= 0.01). Conclusion: These analyses are preliminaries but show a poor outcome of AITL in our population. Most patients were treated with anthracycline-containing combination chemotherapy and just 20% received autologous HSCT. A dismal survival was shown for those who did not receive HSCT.Carlos CHIATTONEEliana MIRANDAGuilherme DUFFLESMarcia DELAMAINJuliana PEREIRANatalia ZINGDanielle FARIASMarcelo BELLESSONelson CASTRORenata BAPTISTAKarin CECYNSuellen MOYana RABELOPatricia RADTKESergio BRASILSamir NABHANGlaciano RIBEIROJoao SOUTO-FILHOVera FIGUEIREDORony SCHAFFELMaria DIASElizete NEGREIROSEduardo RIBEIROMassimo FEDERICOCarmino SOUZAElsevierarticleDiseases of the blood and blood-forming organsRC633-647.5ENHematology, Transfusion and Cell Therapy, Vol 43, Iss , Pp S16-S17 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Diseases of the blood and blood-forming organs RC633-647.5 |
| spellingShingle |
Diseases of the blood and blood-forming organs RC633-647.5 Carlos CHIATTONE Eliana MIRANDA Guilherme DUFFLES Marcia DELAMAIN Juliana PEREIRA Natalia ZING Danielle FARIAS Marcelo BELLESSO Nelson CASTRO Renata BAPTISTA Karin CECYN Suellen MO Yana RABELO Patricia RADTKE Sergio BRASIL Samir NABHAN Glaciano RIBEIRO Joao SOUTO-FILHO Vera FIGUEIREDO Rony SCHAFFEL Maria DIAS Elizete NEGREIROS Eduardo RIBEIRO Massimo FEDERICO Carmino SOUZA UPSHOTS IN ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA: ANALYSIS OF T-CELL BRAZIL PROJECT |
| description |
Objective: T-cell Brazil Project was designed as an ambispective data collection from January 2015 to December 2022 of previously untreated patients diagnosed with Peripheral T-cell lymphoma (PTCL) or NK/T-cell lymphoma according to the revised WHO 2017 classification in Brazil. The primary and secondary end points were 2-year overall survival (OS) and progression-free survival (PFS). Clinical, treatment and survival data were also correlated. Methodology: Twenty centers got approved for the study from the local and national institutional review board and registered their cases only online. OS was calculated from diagnosis date until last seen or death date, whereas PFS until first event, progression / relapse, date of death or last seen. Kaplan-Meier method was applied and a Log-rank test to compare their curves. P-value less than 5% was considered. From a total of 416 patients with PTCL, 46 (11%) were diagnosed as AITL. Results: The median age was 65 years (31-82), with 63% males, 94% had advanced-stage disease. All patients received 61% CHOEP, 28% CHOP and 11% CT without anthracycline. 20% of pts were consolidated with autologous transplant (HSCT). There were 19 (41%) deaths, 10 by lymphoma, 8 infections, 1 new neoplasia. With 8-mo median f/u (1-36), OS at 24-mo was 27% and 2-year PFS was 21%. As consolidation, OS was 71% HSCT group vs. 16% no HSCT (P= 0.06) and PFS was 71% vs. 8%, respectively (P= 0.01). Conclusion: These analyses are preliminaries but show a poor outcome of AITL in our population. Most patients were treated with anthracycline-containing combination chemotherapy and just 20% received autologous HSCT. A dismal survival was shown for those who did not receive HSCT. |
| format |
article |
| author |
Carlos CHIATTONE Eliana MIRANDA Guilherme DUFFLES Marcia DELAMAIN Juliana PEREIRA Natalia ZING Danielle FARIAS Marcelo BELLESSO Nelson CASTRO Renata BAPTISTA Karin CECYN Suellen MO Yana RABELO Patricia RADTKE Sergio BRASIL Samir NABHAN Glaciano RIBEIRO Joao SOUTO-FILHO Vera FIGUEIREDO Rony SCHAFFEL Maria DIAS Elizete NEGREIROS Eduardo RIBEIRO Massimo FEDERICO Carmino SOUZA |
| author_facet |
Carlos CHIATTONE Eliana MIRANDA Guilherme DUFFLES Marcia DELAMAIN Juliana PEREIRA Natalia ZING Danielle FARIAS Marcelo BELLESSO Nelson CASTRO Renata BAPTISTA Karin CECYN Suellen MO Yana RABELO Patricia RADTKE Sergio BRASIL Samir NABHAN Glaciano RIBEIRO Joao SOUTO-FILHO Vera FIGUEIREDO Rony SCHAFFEL Maria DIAS Elizete NEGREIROS Eduardo RIBEIRO Massimo FEDERICO Carmino SOUZA |
| author_sort |
Carlos CHIATTONE |
| title |
UPSHOTS IN ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA: ANALYSIS OF T-CELL BRAZIL PROJECT |
| title_short |
UPSHOTS IN ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA: ANALYSIS OF T-CELL BRAZIL PROJECT |
| title_full |
UPSHOTS IN ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA: ANALYSIS OF T-CELL BRAZIL PROJECT |
| title_fullStr |
UPSHOTS IN ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA: ANALYSIS OF T-CELL BRAZIL PROJECT |
| title_full_unstemmed |
UPSHOTS IN ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA: ANALYSIS OF T-CELL BRAZIL PROJECT |
| title_sort |
upshots in angioimmunoblastic t-cell lymphoma: analysis of t-cell brazil project |
| publisher |
Elsevier |
| publishDate |
2021 |
| url |
https://doaj.org/article/20dc4648a67f400fa1a4587d8fa08899 |
| work_keys_str_mv |
AT carloschiattone upshotsinangioimmunoblastictcelllymphomaanalysisoftcellbrazilproject AT elianamiranda upshotsinangioimmunoblastictcelllymphomaanalysisoftcellbrazilproject AT guilhermeduffles upshotsinangioimmunoblastictcelllymphomaanalysisoftcellbrazilproject AT marciadelamain upshotsinangioimmunoblastictcelllymphomaanalysisoftcellbrazilproject AT julianapereira upshotsinangioimmunoblastictcelllymphomaanalysisoftcellbrazilproject AT nataliazing upshotsinangioimmunoblastictcelllymphomaanalysisoftcellbrazilproject AT daniellefarias upshotsinangioimmunoblastictcelllymphomaanalysisoftcellbrazilproject AT marcelobellesso upshotsinangioimmunoblastictcelllymphomaanalysisoftcellbrazilproject AT nelsoncastro upshotsinangioimmunoblastictcelllymphomaanalysisoftcellbrazilproject AT renatabaptista upshotsinangioimmunoblastictcelllymphomaanalysisoftcellbrazilproject AT karincecyn upshotsinangioimmunoblastictcelllymphomaanalysisoftcellbrazilproject AT suellenmo upshotsinangioimmunoblastictcelllymphomaanalysisoftcellbrazilproject AT yanarabelo upshotsinangioimmunoblastictcelllymphomaanalysisoftcellbrazilproject AT patriciaradtke upshotsinangioimmunoblastictcelllymphomaanalysisoftcellbrazilproject AT sergiobrasil upshotsinangioimmunoblastictcelllymphomaanalysisoftcellbrazilproject AT samirnabhan upshotsinangioimmunoblastictcelllymphomaanalysisoftcellbrazilproject AT glacianoribeiro upshotsinangioimmunoblastictcelllymphomaanalysisoftcellbrazilproject AT joaosoutofilho upshotsinangioimmunoblastictcelllymphomaanalysisoftcellbrazilproject AT verafigueiredo upshotsinangioimmunoblastictcelllymphomaanalysisoftcellbrazilproject AT ronyschaffel upshotsinangioimmunoblastictcelllymphomaanalysisoftcellbrazilproject AT mariadias upshotsinangioimmunoblastictcelllymphomaanalysisoftcellbrazilproject AT elizetenegreiros upshotsinangioimmunoblastictcelllymphomaanalysisoftcellbrazilproject AT eduardoribeiro upshotsinangioimmunoblastictcelllymphomaanalysisoftcellbrazilproject AT massimofederico upshotsinangioimmunoblastictcelllymphomaanalysisoftcellbrazilproject AT carminosouza upshotsinangioimmunoblastictcelllymphomaanalysisoftcellbrazilproject |
| _version_ |
1718440629429600256 |