Effects of curcumin on the bioavailability of dioxin-like pollutants in rats

Abstract The effects of curcumin on the bioavailability of polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (DL-PCBs) were investigated in Sprague–Dawley rats. Tetra- and penta-chlorinated PCDFs had the lowest bioavailability and hexa-chlorinated PCDD/Fs h...

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Autores principales:	Delei Cai, Qing Chen, Jianlong Han, Yanhua Song, Zhen Meng, Yibin Zheng, Haitao Shen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/20dc5822835e4a9e928f4497deaea3e5
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spelling	oai:doaj.org-article:20dc5822835e4a9e928f4497deaea3e52021-12-02T16:04:14ZEffects of curcumin on the bioavailability of dioxin-like pollutants in rats10.1038/s41598-021-92085-32045-2322https://doaj.org/article/20dc5822835e4a9e928f4497deaea3e52021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92085-3https://doaj.org/toc/2045-2322Abstract The effects of curcumin on the bioavailability of polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (DL-PCBs) were investigated in Sprague–Dawley rats. Tetra- and penta-chlorinated PCDFs had the lowest bioavailability and hexa-chlorinated PCDD/Fs had the highest, while there was no obvious change in that of DL-PCBs. Curcumin markedly reduced the toxic equivalent (TEQ) of PCDD/Fs in rats, illustrating the potential to competitively inhibit absorption of PCDD/Fs by the epithelial cells of the small intestine due to the similar chemical structure (diphenyl) between curcumin and PCDD/Fs. Moreover, curcumin lowered the TEQ of DL-PCBs in the liver of male rats, but not female rats. The significant decrease in the bioavailability of PCDD/Fs and DL-PCBs demonstrates the potential detoxification mechanisms of curcumin.Delei CaiQing ChenJianlong HanYanhua SongZhen MengYibin ZhengHaitao ShenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Delei Cai Qing Chen Jianlong Han Yanhua Song Zhen Meng Yibin Zheng Haitao Shen Effects of curcumin on the bioavailability of dioxin-like pollutants in rats
description	Abstract The effects of curcumin on the bioavailability of polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (DL-PCBs) were investigated in Sprague–Dawley rats. Tetra- and penta-chlorinated PCDFs had the lowest bioavailability and hexa-chlorinated PCDD/Fs had the highest, while there was no obvious change in that of DL-PCBs. Curcumin markedly reduced the toxic equivalent (TEQ) of PCDD/Fs in rats, illustrating the potential to competitively inhibit absorption of PCDD/Fs by the epithelial cells of the small intestine due to the similar chemical structure (diphenyl) between curcumin and PCDD/Fs. Moreover, curcumin lowered the TEQ of DL-PCBs in the liver of male rats, but not female rats. The significant decrease in the bioavailability of PCDD/Fs and DL-PCBs demonstrates the potential detoxification mechanisms of curcumin.
format	article
author	Delei Cai Qing Chen Jianlong Han Yanhua Song Zhen Meng Yibin Zheng Haitao Shen
author_facet	Delei Cai Qing Chen Jianlong Han Yanhua Song Zhen Meng Yibin Zheng Haitao Shen
author_sort	Delei Cai
title	Effects of curcumin on the bioavailability of dioxin-like pollutants in rats
title_short	Effects of curcumin on the bioavailability of dioxin-like pollutants in rats
title_full	Effects of curcumin on the bioavailability of dioxin-like pollutants in rats
title_fullStr	Effects of curcumin on the bioavailability of dioxin-like pollutants in rats
title_full_unstemmed	Effects of curcumin on the bioavailability of dioxin-like pollutants in rats
title_sort	effects of curcumin on the bioavailability of dioxin-like pollutants in rats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/20dc5822835e4a9e928f4497deaea3e5
work_keys_str_mv	AT deleicai effectsofcurcuminonthebioavailabilityofdioxinlikepollutantsinrats AT qingchen effectsofcurcuminonthebioavailabilityofdioxinlikepollutantsinrats AT jianlonghan effectsofcurcuminonthebioavailabilityofdioxinlikepollutantsinrats AT yanhuasong effectsofcurcuminonthebioavailabilityofdioxinlikepollutantsinrats AT zhenmeng effectsofcurcuminonthebioavailabilityofdioxinlikepollutantsinrats AT yibinzheng effectsofcurcuminonthebioavailabilityofdioxinlikepollutantsinrats AT haitaoshen effectsofcurcuminonthebioavailabilityofdioxinlikepollutantsinrats
_version_	1718385258798252032

Effects of curcumin on the bioavailability of dioxin-like pollutants in rats

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