Evidence of gene-environment interactions between common breast cancer susceptibility loci and established environmental risk factors.

Various common genetic susceptibility loci have been identified for breast cancer; however, it is unclear how they combine with lifestyle/environmental risk factors to influence risk. We undertook an international collaborative study to assess gene-environment interaction for risk of breast cancer....

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Autores principales:	Stefan Nickels, Thérèse Truong, Rebecca Hein, Kristen Stevens, Katharina Buck, Sabine Behrens, Ursula Eilber, Martina Schmidt, Lothar Häberle, Alina Vrieling, Mia Gaudet, Jonine Figueroa, Nils Schoof, Amanda B Spurdle, Anja Rudolph, Peter A Fasching, John L Hopper, Enes Makalic, Daniel F Schmidt, Melissa C Southey, Matthias W Beckmann, Arif B Ekici, Olivia Fletcher, Lorna Gibson, Isabel dos Santos Silva, Julian Peto, Manjeet K Humphreys, Jean Wang, Emilie Cordina-Duverger, Florence Menegaux, Børge G Nordestgaard, Stig E Bojesen, Charlotte Lanng, Hoda Anton-Culver, Argyrios Ziogas, Leslie Bernstein, Christina A Clarke, Hermann Brenner, Heiko Müller, Volker Arndt, Christa Stegmaier, Hiltrud Brauch, Thomas Brüning, Volker Harth, Genica Network, Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana M Hartikainen, kConFab, AOCS Management Group, Diether Lambrechts, Dominiek Smeets, Patrick Neven, Robert Paridaens, Dieter Flesch-Janys, Nadia Obi, Shan Wang-Gohrke, Fergus J Couch, Janet E Olson, Celine M Vachon, Graham G Giles, Gianluca Severi, Laura Baglietto, Kenneth Offit, Esther M John, Alexander Miron, Irene L Andrulis, Julia A Knight, Gord Glendon, Anna Marie Mulligan, Stephen J Chanock, Jolanta Lissowska, Jianjun Liu, Angela Cox, Helen Cramp, Dan Connley, Sabapathy Balasubramanian, Alison M Dunning, Mitul Shah, Amy Trentham-Dietz, Polly Newcomb, Linda Titus, Kathleen Egan, Elizabeth K Cahoon, Preetha Rajaraman, Alice J Sigurdson, Michele M Doody, Pascal Guénel, Paul D P Pharoah, Marjanka K Schmidt, Per Hall, Doug F Easton, Montserrat Garcia-Closas, Roger L Milne, Jenny Chang-Claude
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Genetics QH426-470
Acceso en línea:	https://doaj.org/article/20dd238908a94b65824d842f548c2872
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spelling	oai:doaj.org-article:20dd238908a94b65824d842f548c28722021-11-18T06:19:52ZEvidence of gene-environment interactions between common breast cancer susceptibility loci and established environmental risk factors.1553-73901553-740410.1371/journal.pgen.1003284https://doaj.org/article/20dd238908a94b65824d842f548c28722013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23544014/?tool=EBIhttps://doaj.org/toc/1553-7390https://doaj.org/toc/1553-7404Various common genetic susceptibility loci have been identified for breast cancer; however, it is unclear how they combine with lifestyle/environmental risk factors to influence risk. We undertook an international collaborative study to assess gene-environment interaction for risk of breast cancer. Data from 24 studies of the Breast Cancer Association Consortium were pooled. Using up to 34,793 invasive breast cancers and 41,099 controls, we examined whether the relative risks associated with 23 single nucleotide polymorphisms were modified by 10 established environmental risk factors (age at menarche, parity, breastfeeding, body mass index, height, oral contraceptive use, menopausal hormone therapy use, alcohol consumption, cigarette smoking, physical activity) in women of European ancestry. We used logistic regression models stratified by study and adjusted for age and performed likelihood ratio tests to assess gene-environment interactions. All statistical tests were two-sided. We replicated previously reported potential interactions between LSP1-rs3817198 and parity (Pinteraction = 2.4 × 10(-6)) and between CASP8-rs17468277 and alcohol consumption (Pinteraction = 3.1 × 10(-4)). Overall, the per-allele odds ratio (95% confidence interval) for LSP1-rs3817198 was 1.08 (1.01-1.16) in nulliparous women and ranged from 1.03 (0.96-1.10) in parous women with one birth to 1.26 (1.16-1.37) in women with at least four births. For CASP8-rs17468277, the per-allele OR was 0.91 (0.85-0.98) in those with an alcohol intake of <20 g/day and 1.45 (1.14-1.85) in those who drank ≥ 20 g/day. Additionally, interaction was found between 1p11.2-rs11249433 and ever being parous (Pinteraction = 5.3 × 10(-5)), with a per-allele OR of 1.14 (1.11-1.17) in parous women and 0.98 (0.92-1.05) in nulliparous women. These data provide first strong evidence that the risk of breast cancer associated with some common genetic variants may vary with environmental risk factors.Stefan NickelsThérèse TruongRebecca HeinKristen StevensKatharina BuckSabine BehrensUrsula EilberMartina SchmidtLothar HäberleAlina VrielingMia GaudetJonine FigueroaNils SchoofAmanda B SpurdleAnja RudolphPeter A FaschingJohn L HopperEnes MakalicDaniel F SchmidtMelissa C SoutheyMatthias W BeckmannArif B EkiciOlivia FletcherLorna GibsonIsabel dos Santos SilvaJulian PetoManjeet K HumphreysJean WangEmilie Cordina-DuvergerFlorence MenegauxBørge G NordestgaardStig E BojesenCharlotte LanngHoda Anton-CulverArgyrios ZiogasLeslie BernsteinChristina A ClarkeHermann BrennerHeiko MüllerVolker ArndtChrista StegmaierHiltrud BrauchThomas BrüningVolker HarthGenica NetworkArto MannermaaVesa KatajaVeli-Matti KosmaJaana M HartikainenkConFabAOCS Management GroupDiether LambrechtsDominiek SmeetsPatrick NevenRobert ParidaensDieter Flesch-JanysNadia ObiShan Wang-GohrkeFergus J CouchJanet E OlsonCeline M VachonGraham G GilesGianluca SeveriLaura BagliettoKenneth OffitEsther M JohnAlexander MironIrene L AndrulisJulia A KnightGord GlendonAnna Marie MulliganStephen J ChanockJolanta LissowskaJianjun LiuAngela CoxHelen CrampDan ConnleySabapathy BalasubramanianAlison M DunningMitul ShahAmy Trentham-DietzPolly NewcombLinda TitusKathleen EganElizabeth K CahoonPreetha RajaramanAlice J SigurdsonMichele M DoodyPascal GuénelPaul D P PharoahMarjanka K SchmidtPer HallDoug F EastonMontserrat Garcia-ClosasRoger L MilneJenny Chang-ClaudePublic Library of Science (PLoS)articleGeneticsQH426-470ENPLoS Genetics, Vol 9, Iss 3, p e1003284 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Genetics QH426-470
spellingShingle	Genetics QH426-470 Stefan Nickels Thérèse Truong Rebecca Hein Kristen Stevens Katharina Buck Sabine Behrens Ursula Eilber Martina Schmidt Lothar Häberle Alina Vrieling Mia Gaudet Jonine Figueroa Nils Schoof Amanda B Spurdle Anja Rudolph Peter A Fasching John L Hopper Enes Makalic Daniel F Schmidt Melissa C Southey Matthias W Beckmann Arif B Ekici Olivia Fletcher Lorna Gibson Isabel dos Santos Silva Julian Peto Manjeet K Humphreys Jean Wang Emilie Cordina-Duverger Florence Menegaux Børge G Nordestgaard Stig E Bojesen Charlotte Lanng Hoda Anton-Culver Argyrios Ziogas Leslie Bernstein Christina A Clarke Hermann Brenner Heiko Müller Volker Arndt Christa Stegmaier Hiltrud Brauch Thomas Brüning Volker Harth Genica Network Arto Mannermaa Vesa Kataja Veli-Matti Kosma Jaana M Hartikainen kConFab AOCS Management Group Diether Lambrechts Dominiek Smeets Patrick Neven Robert Paridaens Dieter Flesch-Janys Nadia Obi Shan Wang-Gohrke Fergus J Couch Janet E Olson Celine M Vachon Graham G Giles Gianluca Severi Laura Baglietto Kenneth Offit Esther M John Alexander Miron Irene L Andrulis Julia A Knight Gord Glendon Anna Marie Mulligan Stephen J Chanock Jolanta Lissowska Jianjun Liu Angela Cox Helen Cramp Dan Connley Sabapathy Balasubramanian Alison M Dunning Mitul Shah Amy Trentham-Dietz Polly Newcomb Linda Titus Kathleen Egan Elizabeth K Cahoon Preetha Rajaraman Alice J Sigurdson Michele M Doody Pascal Guénel Paul D P Pharoah Marjanka K Schmidt Per Hall Doug F Easton Montserrat Garcia-Closas Roger L Milne Jenny Chang-Claude Evidence of gene-environment interactions between common breast cancer susceptibility loci and established environmental risk factors.
description	Various common genetic susceptibility loci have been identified for breast cancer; however, it is unclear how they combine with lifestyle/environmental risk factors to influence risk. We undertook an international collaborative study to assess gene-environment interaction for risk of breast cancer. Data from 24 studies of the Breast Cancer Association Consortium were pooled. Using up to 34,793 invasive breast cancers and 41,099 controls, we examined whether the relative risks associated with 23 single nucleotide polymorphisms were modified by 10 established environmental risk factors (age at menarche, parity, breastfeeding, body mass index, height, oral contraceptive use, menopausal hormone therapy use, alcohol consumption, cigarette smoking, physical activity) in women of European ancestry. We used logistic regression models stratified by study and adjusted for age and performed likelihood ratio tests to assess gene-environment interactions. All statistical tests were two-sided. We replicated previously reported potential interactions between LSP1-rs3817198 and parity (Pinteraction = 2.4 × 10(-6)) and between CASP8-rs17468277 and alcohol consumption (Pinteraction = 3.1 × 10(-4)). Overall, the per-allele odds ratio (95% confidence interval) for LSP1-rs3817198 was 1.08 (1.01-1.16) in nulliparous women and ranged from 1.03 (0.96-1.10) in parous women with one birth to 1.26 (1.16-1.37) in women with at least four births. For CASP8-rs17468277, the per-allele OR was 0.91 (0.85-0.98) in those with an alcohol intake of <20 g/day and 1.45 (1.14-1.85) in those who drank ≥ 20 g/day. Additionally, interaction was found between 1p11.2-rs11249433 and ever being parous (Pinteraction = 5.3 × 10(-5)), with a per-allele OR of 1.14 (1.11-1.17) in parous women and 0.98 (0.92-1.05) in nulliparous women. These data provide first strong evidence that the risk of breast cancer associated with some common genetic variants may vary with environmental risk factors.
format	article
author	Stefan Nickels Thérèse Truong Rebecca Hein Kristen Stevens Katharina Buck Sabine Behrens Ursula Eilber Martina Schmidt Lothar Häberle Alina Vrieling Mia Gaudet Jonine Figueroa Nils Schoof Amanda B Spurdle Anja Rudolph Peter A Fasching John L Hopper Enes Makalic Daniel F Schmidt Melissa C Southey Matthias W Beckmann Arif B Ekici Olivia Fletcher Lorna Gibson Isabel dos Santos Silva Julian Peto Manjeet K Humphreys Jean Wang Emilie Cordina-Duverger Florence Menegaux Børge G Nordestgaard Stig E Bojesen Charlotte Lanng Hoda Anton-Culver Argyrios Ziogas Leslie Bernstein Christina A Clarke Hermann Brenner Heiko Müller Volker Arndt Christa Stegmaier Hiltrud Brauch Thomas Brüning Volker Harth Genica Network Arto Mannermaa Vesa Kataja Veli-Matti Kosma Jaana M Hartikainen kConFab AOCS Management Group Diether Lambrechts Dominiek Smeets Patrick Neven Robert Paridaens Dieter Flesch-Janys Nadia Obi Shan Wang-Gohrke Fergus J Couch Janet E Olson Celine M Vachon Graham G Giles Gianluca Severi Laura Baglietto Kenneth Offit Esther M John Alexander Miron Irene L Andrulis Julia A Knight Gord Glendon Anna Marie Mulligan Stephen J Chanock Jolanta Lissowska Jianjun Liu Angela Cox Helen Cramp Dan Connley Sabapathy Balasubramanian Alison M Dunning Mitul Shah Amy Trentham-Dietz Polly Newcomb Linda Titus Kathleen Egan Elizabeth K Cahoon Preetha Rajaraman Alice J Sigurdson Michele M Doody Pascal Guénel Paul D P Pharoah Marjanka K Schmidt Per Hall Doug F Easton Montserrat Garcia-Closas Roger L Milne Jenny Chang-Claude
author_facet	Stefan Nickels Thérèse Truong Rebecca Hein Kristen Stevens Katharina Buck Sabine Behrens Ursula Eilber Martina Schmidt Lothar Häberle Alina Vrieling Mia Gaudet Jonine Figueroa Nils Schoof Amanda B Spurdle Anja Rudolph Peter A Fasching John L Hopper Enes Makalic Daniel F Schmidt Melissa C Southey Matthias W Beckmann Arif B Ekici Olivia Fletcher Lorna Gibson Isabel dos Santos Silva Julian Peto Manjeet K Humphreys Jean Wang Emilie Cordina-Duverger Florence Menegaux Børge G Nordestgaard Stig E Bojesen Charlotte Lanng Hoda Anton-Culver Argyrios Ziogas Leslie Bernstein Christina A Clarke Hermann Brenner Heiko Müller Volker Arndt Christa Stegmaier Hiltrud Brauch Thomas Brüning Volker Harth Genica Network Arto Mannermaa Vesa Kataja Veli-Matti Kosma Jaana M Hartikainen kConFab AOCS Management Group Diether Lambrechts Dominiek Smeets Patrick Neven Robert Paridaens Dieter Flesch-Janys Nadia Obi Shan Wang-Gohrke Fergus J Couch Janet E Olson Celine M Vachon Graham G Giles Gianluca Severi Laura Baglietto Kenneth Offit Esther M John Alexander Miron Irene L Andrulis Julia A Knight Gord Glendon Anna Marie Mulligan Stephen J Chanock Jolanta Lissowska Jianjun Liu Angela Cox Helen Cramp Dan Connley Sabapathy Balasubramanian Alison M Dunning Mitul Shah Amy Trentham-Dietz Polly Newcomb Linda Titus Kathleen Egan Elizabeth K Cahoon Preetha Rajaraman Alice J Sigurdson Michele M Doody Pascal Guénel Paul D P Pharoah Marjanka K Schmidt Per Hall Doug F Easton Montserrat Garcia-Closas Roger L Milne Jenny Chang-Claude
author_sort	Stefan Nickels
title	Evidence of gene-environment interactions between common breast cancer susceptibility loci and established environmental risk factors.
title_short	Evidence of gene-environment interactions between common breast cancer susceptibility loci and established environmental risk factors.
title_full	Evidence of gene-environment interactions between common breast cancer susceptibility loci and established environmental risk factors.
title_fullStr	Evidence of gene-environment interactions between common breast cancer susceptibility loci and established environmental risk factors.
title_full_unstemmed	Evidence of gene-environment interactions between common breast cancer susceptibility loci and established environmental risk factors.
title_sort	evidence of gene-environment interactions between common breast cancer susceptibility loci and established environmental risk factors.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/20dd238908a94b65824d842f548c2872
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Evidence of gene-environment interactions between common breast cancer susceptibility loci and established environmental risk factors.

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