Prevalence of Congenital Heart Defects in Pregnancies Conceived by Assisted Reproductive Technology: A Cohort Study

Background and aim of the study: Pregnancies obtained by assisted reproductive technology (ART) are associated with an increased risk of complications and congenital anomalies, particularly congenital heart defects (CHDs). Therefore, our aim is to evaluate, retrospectively, the prevalence of CHD in...

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Autores principales:	Alessandro Galdini, Vlasta M. E. Fesslova, Gerarda Gaeta, Massimo Candiani, Mirko Pozzoni, Carmelina Chiarello, Paolo Ivo Cavoretto
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	in vitro fertilization IVF ICSI intracytoplasmic sperm injection assisted reproductive technology ART Medicine R
Acceso en línea:	https://doaj.org/article/20e04d7e4b0145d1bf276afd54229901
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spelling	oai:doaj.org-article:20e04d7e4b0145d1bf276afd542299012021-11-25T18:02:08ZPrevalence of Congenital Heart Defects in Pregnancies Conceived by Assisted Reproductive Technology: A Cohort Study10.3390/jcm102253632077-0383https://doaj.org/article/20e04d7e4b0145d1bf276afd542299012021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5363https://doaj.org/toc/2077-0383Background and aim of the study: Pregnancies obtained by assisted reproductive technology (ART) are associated with an increased risk of complications and congenital anomalies, particularly congenital heart defects (CHDs). Therefore, our aim is to evaluate, retrospectively, the prevalence of CHD in ART pregnancies in our two centers and analyze their characteristics and outcomes. Methods: Observational study including fetuses conceived by ART referred between June 2011 and September 2020 and undergoing a fetal cardiac ultrasound scan. Cases with genetic, chromosomal abnormalities or extracardiac malformations were excluded. Population included 1511 pregnancies, which consisted of 269 twins and 1242 singletons, 547 IVF (in vitro fertilization), 773 ICSI (intracytoplasmic sperm injection) and 191 oocyte donations (OD). Results: CHDs were found in 29 fetuses, with an overall prevalence of 1.92% (29/1511), 1.85% (23/1242) in singletons and 2.23% in twins (6/269). Thirteen were IVF, eight ICSI and eight OD cases, with a greater risk of CHD after IVF and OD (IVF: 13/29 (44.8%)—one twin; ICSI: 8/29 (27.6%)—three twins); 22 had major and 7 minor defects. Two pregnancies with a hypoplastic left heart were terminated; the majority of live-born cases needed surgery. Three babies died (two post-surgery, one had a late death). Conclusions: Our data show an increased prevalence of CHD after ART with a heterogeneous spectrum of diagnoses, mainly major defects.Alessandro GaldiniVlasta M. E. FesslovaGerarda GaetaMassimo CandianiMirko PozzoniCarmelina ChiarelloPaolo Ivo CavorettoMDPI AGarticlein vitro fertilizationIVFICSIintracytoplasmic sperm injectionassisted reproductive technologyARTMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5363, p 5363 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	in vitro fertilization IVF ICSI intracytoplasmic sperm injection assisted reproductive technology ART Medicine R
spellingShingle	in vitro fertilization IVF ICSI intracytoplasmic sperm injection assisted reproductive technology ART Medicine R Alessandro Galdini Vlasta M. E. Fesslova Gerarda Gaeta Massimo Candiani Mirko Pozzoni Carmelina Chiarello Paolo Ivo Cavoretto Prevalence of Congenital Heart Defects in Pregnancies Conceived by Assisted Reproductive Technology: A Cohort Study
description	Background and aim of the study: Pregnancies obtained by assisted reproductive technology (ART) are associated with an increased risk of complications and congenital anomalies, particularly congenital heart defects (CHDs). Therefore, our aim is to evaluate, retrospectively, the prevalence of CHD in ART pregnancies in our two centers and analyze their characteristics and outcomes. Methods: Observational study including fetuses conceived by ART referred between June 2011 and September 2020 and undergoing a fetal cardiac ultrasound scan. Cases with genetic, chromosomal abnormalities or extracardiac malformations were excluded. Population included 1511 pregnancies, which consisted of 269 twins and 1242 singletons, 547 IVF (in vitro fertilization), 773 ICSI (intracytoplasmic sperm injection) and 191 oocyte donations (OD). Results: CHDs were found in 29 fetuses, with an overall prevalence of 1.92% (29/1511), 1.85% (23/1242) in singletons and 2.23% in twins (6/269). Thirteen were IVF, eight ICSI and eight OD cases, with a greater risk of CHD after IVF and OD (IVF: 13/29 (44.8%)—one twin; ICSI: 8/29 (27.6%)—three twins); 22 had major and 7 minor defects. Two pregnancies with a hypoplastic left heart were terminated; the majority of live-born cases needed surgery. Three babies died (two post-surgery, one had a late death). Conclusions: Our data show an increased prevalence of CHD after ART with a heterogeneous spectrum of diagnoses, mainly major defects.
format	article
author	Alessandro Galdini Vlasta M. E. Fesslova Gerarda Gaeta Massimo Candiani Mirko Pozzoni Carmelina Chiarello Paolo Ivo Cavoretto
author_facet	Alessandro Galdini Vlasta M. E. Fesslova Gerarda Gaeta Massimo Candiani Mirko Pozzoni Carmelina Chiarello Paolo Ivo Cavoretto
author_sort	Alessandro Galdini
title	Prevalence of Congenital Heart Defects in Pregnancies Conceived by Assisted Reproductive Technology: A Cohort Study
title_short	Prevalence of Congenital Heart Defects in Pregnancies Conceived by Assisted Reproductive Technology: A Cohort Study
title_full	Prevalence of Congenital Heart Defects in Pregnancies Conceived by Assisted Reproductive Technology: A Cohort Study
title_fullStr	Prevalence of Congenital Heart Defects in Pregnancies Conceived by Assisted Reproductive Technology: A Cohort Study
title_full_unstemmed	Prevalence of Congenital Heart Defects in Pregnancies Conceived by Assisted Reproductive Technology: A Cohort Study
title_sort	prevalence of congenital heart defects in pregnancies conceived by assisted reproductive technology: a cohort study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/20e04d7e4b0145d1bf276afd54229901
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_version_	1718411667518259200

Prevalence of Congenital Heart Defects in Pregnancies Conceived by Assisted Reproductive Technology: A Cohort Study

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