Oxytocin administration suppresses hypothalamic activation in response to visual food cues

Abstract The aim of this study was to use functional neuroimaging to investigate whether oxytocin modulates the neural response to visual food cues in brain regions involved in the control of food intake. Twenty-four normal weight volunteers received intranasal oxytocin (24 IU) or placebo in a doubl...

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Autores principales:	Agatha A. van der Klaauw, Hisham Ziauddeen, Julia M. Keogh, Elana Henning, Sekesai Dachi, Paul C. Fletcher, I. Sadaf Farooqi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/20e412beb17a44e8a8ee4e572b43fdd1
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spelling	oai:doaj.org-article:20e412beb17a44e8a8ee4e572b43fdd12021-12-02T15:04:55ZOxytocin administration suppresses hypothalamic activation in response to visual food cues10.1038/s41598-017-04600-02045-2322https://doaj.org/article/20e412beb17a44e8a8ee4e572b43fdd12017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04600-0https://doaj.org/toc/2045-2322Abstract The aim of this study was to use functional neuroimaging to investigate whether oxytocin modulates the neural response to visual food cues in brain regions involved in the control of food intake. Twenty-four normal weight volunteers received intranasal oxytocin (24 IU) or placebo in a double-blind, randomized crossover study. Measurements were made forty-five minutes after dosing. On two occasions, functional MRI (fMRI) scans were performed in the fasted state; the blood oxygen level-dependent (BOLD) response to images of high-calorie foods versus low-calorie foods was measured. Given its critical role in eating behaviour, the primary region of interest was the hypothalamus. Secondary analyses examined the parabrachial nuclei and other brain regions involved in food intake and food reward. Intranasal oxytocin administration suppressed hypothalamic activation to images of high-calorie compared to low-calorie food (P = 0.0125). There was also a trend towards suppression of activation in the parabrachial nucleus (P = 0.0683). No effects of intranasal oxytocin were seen in reward circuits or on ad libitum food intake. Further characterization of the effects of oxytocin on neural circuits in the hypothalamus is needed to establish the utility of targeting oxytocin signalling in obesity.Agatha A. van der KlaauwHisham ZiauddeenJulia M. KeoghElana HenningSekesai DachiPaul C. FletcherI. Sadaf FarooqiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-5 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Agatha A. van der Klaauw Hisham Ziauddeen Julia M. Keogh Elana Henning Sekesai Dachi Paul C. Fletcher I. Sadaf Farooqi Oxytocin administration suppresses hypothalamic activation in response to visual food cues
description	Abstract The aim of this study was to use functional neuroimaging to investigate whether oxytocin modulates the neural response to visual food cues in brain regions involved in the control of food intake. Twenty-four normal weight volunteers received intranasal oxytocin (24 IU) or placebo in a double-blind, randomized crossover study. Measurements were made forty-five minutes after dosing. On two occasions, functional MRI (fMRI) scans were performed in the fasted state; the blood oxygen level-dependent (BOLD) response to images of high-calorie foods versus low-calorie foods was measured. Given its critical role in eating behaviour, the primary region of interest was the hypothalamus. Secondary analyses examined the parabrachial nuclei and other brain regions involved in food intake and food reward. Intranasal oxytocin administration suppressed hypothalamic activation to images of high-calorie compared to low-calorie food (P = 0.0125). There was also a trend towards suppression of activation in the parabrachial nucleus (P = 0.0683). No effects of intranasal oxytocin were seen in reward circuits or on ad libitum food intake. Further characterization of the effects of oxytocin on neural circuits in the hypothalamus is needed to establish the utility of targeting oxytocin signalling in obesity.
format	article
author	Agatha A. van der Klaauw Hisham Ziauddeen Julia M. Keogh Elana Henning Sekesai Dachi Paul C. Fletcher I. Sadaf Farooqi
author_facet	Agatha A. van der Klaauw Hisham Ziauddeen Julia M. Keogh Elana Henning Sekesai Dachi Paul C. Fletcher I. Sadaf Farooqi
author_sort	Agatha A. van der Klaauw
title	Oxytocin administration suppresses hypothalamic activation in response to visual food cues
title_short	Oxytocin administration suppresses hypothalamic activation in response to visual food cues
title_full	Oxytocin administration suppresses hypothalamic activation in response to visual food cues
title_fullStr	Oxytocin administration suppresses hypothalamic activation in response to visual food cues
title_full_unstemmed	Oxytocin administration suppresses hypothalamic activation in response to visual food cues
title_sort	oxytocin administration suppresses hypothalamic activation in response to visual food cues
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/20e412beb17a44e8a8ee4e572b43fdd1
work_keys_str_mv	AT agathaavanderklaauw oxytocinadministrationsuppresseshypothalamicactivationinresponsetovisualfoodcues AT hishamziauddeen oxytocinadministrationsuppresseshypothalamicactivationinresponsetovisualfoodcues AT juliamkeogh oxytocinadministrationsuppresseshypothalamicactivationinresponsetovisualfoodcues AT elanahenning oxytocinadministrationsuppresseshypothalamicactivationinresponsetovisualfoodcues AT sekesaidachi oxytocinadministrationsuppresseshypothalamicactivationinresponsetovisualfoodcues AT paulcfletcher oxytocinadministrationsuppresseshypothalamicactivationinresponsetovisualfoodcues AT isadaffarooqi oxytocinadministrationsuppresseshypothalamicactivationinresponsetovisualfoodcues
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Oxytocin administration suppresses hypothalamic activation in response to visual food cues

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