Low excitatory innervation balances high intrinsic excitability of immature dentate neurons

Immature dentate gyrus neurons are highly excitable and are thought to be more responsive to afferent activity than mature neurons. Here, the authors find stimulation of the entorhinal cortex paradoxically generates spiking in mature rather than immature neurons due to low synaptic connectivity of i...

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Autores principales:	Cristina V. Dieni, Roberto Panichi, James B. Aimone, Chay T. Kuo, Jacques I. Wadiche, Linda Overstreet-Wadiche
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/20e517ec89bc4a7fbd349a98671c418c
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spelling	oai:doaj.org-article:20e517ec89bc4a7fbd349a98671c418c2021-12-02T14:39:29ZLow excitatory innervation balances high intrinsic excitability of immature dentate neurons10.1038/ncomms113132041-1723https://doaj.org/article/20e517ec89bc4a7fbd349a98671c418c2016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11313https://doaj.org/toc/2041-1723Immature dentate gyrus neurons are highly excitable and are thought to be more responsive to afferent activity than mature neurons. Here, the authors find stimulation of the entorhinal cortex paradoxically generates spiking in mature rather than immature neurons due to low synaptic connectivity of immature cells.Cristina V. DieniRoberto PanichiJames B. AimoneChay T. KuoJacques I. WadicheLinda Overstreet-WadicheNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cristina V. Dieni Roberto Panichi James B. Aimone Chay T. Kuo Jacques I. Wadiche Linda Overstreet-Wadiche Low excitatory innervation balances high intrinsic excitability of immature dentate neurons
description	Immature dentate gyrus neurons are highly excitable and are thought to be more responsive to afferent activity than mature neurons. Here, the authors find stimulation of the entorhinal cortex paradoxically generates spiking in mature rather than immature neurons due to low synaptic connectivity of immature cells.
format	article
author	Cristina V. Dieni Roberto Panichi James B. Aimone Chay T. Kuo Jacques I. Wadiche Linda Overstreet-Wadiche
author_facet	Cristina V. Dieni Roberto Panichi James B. Aimone Chay T. Kuo Jacques I. Wadiche Linda Overstreet-Wadiche
author_sort	Cristina V. Dieni
title	Low excitatory innervation balances high intrinsic excitability of immature dentate neurons
title_short	Low excitatory innervation balances high intrinsic excitability of immature dentate neurons
title_full	Low excitatory innervation balances high intrinsic excitability of immature dentate neurons
title_fullStr	Low excitatory innervation balances high intrinsic excitability of immature dentate neurons
title_full_unstemmed	Low excitatory innervation balances high intrinsic excitability of immature dentate neurons
title_sort	low excitatory innervation balances high intrinsic excitability of immature dentate neurons
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/20e517ec89bc4a7fbd349a98671c418c
work_keys_str_mv	AT cristinavdieni lowexcitatoryinnervationbalanceshighintrinsicexcitabilityofimmaturedentateneurons AT robertopanichi lowexcitatoryinnervationbalanceshighintrinsicexcitabilityofimmaturedentateneurons AT jamesbaimone lowexcitatoryinnervationbalanceshighintrinsicexcitabilityofimmaturedentateneurons AT chaytkuo lowexcitatoryinnervationbalanceshighintrinsicexcitabilityofimmaturedentateneurons AT jacquesiwadiche lowexcitatoryinnervationbalanceshighintrinsicexcitabilityofimmaturedentateneurons AT lindaoverstreetwadiche lowexcitatoryinnervationbalanceshighintrinsicexcitabilityofimmaturedentateneurons
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Low excitatory innervation balances high intrinsic excitability of immature dentate neurons

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