Zamilon, a novel virophage with Mimiviridae host specificity.

Virophages, which are potentially important ecological regulators, have been discovered in association with members of the order Megavirales. Sputnik virophages target the Mimiviridae, Mavirus was identified with the Cafeteria roenbergensis virus, and virophage genomes reconstructed by metagenomic a...

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Autores principales:	Morgan Gaia, Samia Benamar, Mondher Boughalmi, Isabelle Pagnier, Olivier Croce, Philippe Colson, Didier Raoult, Bernard La Scola
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/20e636ae50a5430f82e872652f2cce0b
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spelling	oai:doaj.org-article:20e636ae50a5430f82e872652f2cce0b2021-11-18T08:22:33ZZamilon, a novel virophage with Mimiviridae host specificity.1932-620310.1371/journal.pone.0094923https://doaj.org/article/20e636ae50a5430f82e872652f2cce0b2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24747414/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Virophages, which are potentially important ecological regulators, have been discovered in association with members of the order Megavirales. Sputnik virophages target the Mimiviridae, Mavirus was identified with the Cafeteria roenbergensis virus, and virophage genomes reconstructed by metagenomic analyses may be associated with the Phycodnaviridae. Despite the fact that the Sputnik virophages were isolated with viruses belonging to group A of the Mimiviridae, they can grow in amoebae infected by Mimiviridae from groups A, B or C. In this study we describe Zamilon, the first virophage isolated with a member of group C of the Mimiviridae family. By co-culturing amoebae with purified Zamilon, we found that the virophage is able to multiply with members of groups B and C of the Mimiviridae family but not with viruses from group A. Zamilon has a 17,276 bp DNA genome that potentially encodes 20 genes. Most of these genes are closely related to genes from the Sputnik virophage, yet two are more related to Megavirus chiliensis genes, a group B Mimiviridae, and one to Moumouvirus monve transpoviron.Morgan GaiaSamia BenamarMondher BoughalmiIsabelle PagnierOlivier CrocePhilippe ColsonDidier RaoultBernard La ScolaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 4, p e94923 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Morgan Gaia Samia Benamar Mondher Boughalmi Isabelle Pagnier Olivier Croce Philippe Colson Didier Raoult Bernard La Scola Zamilon, a novel virophage with Mimiviridae host specificity.
description	Virophages, which are potentially important ecological regulators, have been discovered in association with members of the order Megavirales. Sputnik virophages target the Mimiviridae, Mavirus was identified with the Cafeteria roenbergensis virus, and virophage genomes reconstructed by metagenomic analyses may be associated with the Phycodnaviridae. Despite the fact that the Sputnik virophages were isolated with viruses belonging to group A of the Mimiviridae, they can grow in amoebae infected by Mimiviridae from groups A, B or C. In this study we describe Zamilon, the first virophage isolated with a member of group C of the Mimiviridae family. By co-culturing amoebae with purified Zamilon, we found that the virophage is able to multiply with members of groups B and C of the Mimiviridae family but not with viruses from group A. Zamilon has a 17,276 bp DNA genome that potentially encodes 20 genes. Most of these genes are closely related to genes from the Sputnik virophage, yet two are more related to Megavirus chiliensis genes, a group B Mimiviridae, and one to Moumouvirus monve transpoviron.
format	article
author	Morgan Gaia Samia Benamar Mondher Boughalmi Isabelle Pagnier Olivier Croce Philippe Colson Didier Raoult Bernard La Scola
author_facet	Morgan Gaia Samia Benamar Mondher Boughalmi Isabelle Pagnier Olivier Croce Philippe Colson Didier Raoult Bernard La Scola
author_sort	Morgan Gaia
title	Zamilon, a novel virophage with Mimiviridae host specificity.
title_short	Zamilon, a novel virophage with Mimiviridae host specificity.
title_full	Zamilon, a novel virophage with Mimiviridae host specificity.
title_fullStr	Zamilon, a novel virophage with Mimiviridae host specificity.
title_full_unstemmed	Zamilon, a novel virophage with Mimiviridae host specificity.
title_sort	zamilon, a novel virophage with mimiviridae host specificity.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/20e636ae50a5430f82e872652f2cce0b
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Zamilon, a novel virophage with Mimiviridae host specificity.

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