Structural basis for broad neutralization of ebolaviruses by an antibody targeting the glycoprotein fusion loop

The Ebola virus glycoprotein is a target for cross-protective antibodies. Here, Janus et al. report the crystal structure of the antigen-binding fragment of a pan-reactive antibody bound to a conserved epitope of the glycoprotein, facilitating rational design of cross-protective vaccines and therape...

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Autores principales:	Benjamin M. Janus, Nydia van Dyk, Xuelian Zhao, Katie A. Howell, Cinque Soto, M. Javad Aman, Yuxing Li, Thomas R. Fuerst, Gilad Ofek
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/20e66fb349b04412a89f063ca2921f9c
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spelling	oai:doaj.org-article:20e66fb349b04412a89f063ca2921f9c2021-12-02T14:39:08ZStructural basis for broad neutralization of ebolaviruses by an antibody targeting the glycoprotein fusion loop10.1038/s41467-018-06113-42041-1723https://doaj.org/article/20e66fb349b04412a89f063ca2921f9c2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06113-4https://doaj.org/toc/2041-1723The Ebola virus glycoprotein is a target for cross-protective antibodies. Here, Janus et al. report the crystal structure of the antigen-binding fragment of a pan-reactive antibody bound to a conserved epitope of the glycoprotein, facilitating rational design of cross-protective vaccines and therapeutics.Benjamin M. JanusNydia van DykXuelian ZhaoKatie A. HowellCinque SotoM. Javad AmanYuxing LiThomas R. FuerstGilad OfekNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Benjamin M. Janus Nydia van Dyk Xuelian Zhao Katie A. Howell Cinque Soto M. Javad Aman Yuxing Li Thomas R. Fuerst Gilad Ofek Structural basis for broad neutralization of ebolaviruses by an antibody targeting the glycoprotein fusion loop
description	The Ebola virus glycoprotein is a target for cross-protective antibodies. Here, Janus et al. report the crystal structure of the antigen-binding fragment of a pan-reactive antibody bound to a conserved epitope of the glycoprotein, facilitating rational design of cross-protective vaccines and therapeutics.
format	article
author	Benjamin M. Janus Nydia van Dyk Xuelian Zhao Katie A. Howell Cinque Soto M. Javad Aman Yuxing Li Thomas R. Fuerst Gilad Ofek
author_facet	Benjamin M. Janus Nydia van Dyk Xuelian Zhao Katie A. Howell Cinque Soto M. Javad Aman Yuxing Li Thomas R. Fuerst Gilad Ofek
author_sort	Benjamin M. Janus
title	Structural basis for broad neutralization of ebolaviruses by an antibody targeting the glycoprotein fusion loop
title_short	Structural basis for broad neutralization of ebolaviruses by an antibody targeting the glycoprotein fusion loop
title_full	Structural basis for broad neutralization of ebolaviruses by an antibody targeting the glycoprotein fusion loop
title_fullStr	Structural basis for broad neutralization of ebolaviruses by an antibody targeting the glycoprotein fusion loop
title_full_unstemmed	Structural basis for broad neutralization of ebolaviruses by an antibody targeting the glycoprotein fusion loop
title_sort	structural basis for broad neutralization of ebolaviruses by an antibody targeting the glycoprotein fusion loop
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/20e66fb349b04412a89f063ca2921f9c
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Structural basis for broad neutralization of ebolaviruses by an antibody targeting the glycoprotein fusion loop

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